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The efficacy of live attenuated and inactivated influenza vaccines in children as a function of time postvaccination.
Pediatr Infect Dis J. 2010 Sep; 29(9):806-11.PI

Abstract

BACKGROUND

In the United States, more children are being vaccinated against influenza in August and September, months before peak influenza activity. Sustained vaccine efficacy through 12 months postvaccination has been demonstrated in children for live attenuated influenza vaccine (LAIV) but not trivalent inactivated influenza vaccine (TIV). Three large, randomized studies compared LAIV and TIV efficacy in children, providing the opportunity to examine the impact of time on the relative efficacy of the 2 vaccines.

METHODS

For each study, the relative efficacy of LAIV versus TIV was analyzed by time interval (0-4 and >4-8 months postvaccination) for matched and mismatched strains.

RESULTS

LAIV recipients had less influenza than TIV recipients during both intervals; the relative efficacy of LAIV versus TIV for matched strains in each study increased from 0 to 4 months (range, 25%-60%) to >4 to 8 months (range, 49%-89%). Analysis of the incidence of individual types/subtypes revealed the same pattern for the predominant matched strain in each study; no consistent pattern was seen for lower-incidence matched strains. For mismatched strains, similar relative efficacy was seen in each time interval.

CONCLUSIONS

For matched strains, data suggest that the relative efficacy of LAIV versus TIV in young children increases over time. Consistent with previous studies of TIV-induced immunity, this analysis suggests that the absolute efficacy of TIV against matched strains in children may be lower at >4 to 8 versus 0 to 4 months postvaccination. Relative efficacy against mismatched strains was similar over time, consistent with previous estimates of the absolute efficacies of the vaccines against mismatched strains. Further research is needed to confirm these findings and to characterize the duration of protection provided by TIV in children.

Authors+Show Affiliations

MedImmune LLC, Gaithersburg, MD, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20458256

Citation

Ambrose, Christopher S., et al. "The Efficacy of Live Attenuated and Inactivated Influenza Vaccines in Children as a Function of Time Postvaccination." The Pediatric Infectious Disease Journal, vol. 29, no. 9, 2010, pp. 806-11.
Ambrose CS, Wu X, Belshe RB. The efficacy of live attenuated and inactivated influenza vaccines in children as a function of time postvaccination. Pediatr Infect Dis J. 2010;29(9):806-11.
Ambrose, C. S., Wu, X., & Belshe, R. B. (2010). The efficacy of live attenuated and inactivated influenza vaccines in children as a function of time postvaccination. The Pediatric Infectious Disease Journal, 29(9), 806-11. https://doi.org/10.1097/INF.0b013e3181e2872f
Ambrose CS, Wu X, Belshe RB. The Efficacy of Live Attenuated and Inactivated Influenza Vaccines in Children as a Function of Time Postvaccination. Pediatr Infect Dis J. 2010;29(9):806-11. PubMed PMID: 20458256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy of live attenuated and inactivated influenza vaccines in children as a function of time postvaccination. AU - Ambrose,Christopher S, AU - Wu,Xionghua, AU - Belshe,Robert B, PY - 2010/5/12/entrez PY - 2010/5/12/pubmed PY - 2010/12/14/medline SP - 806 EP - 11 JF - The Pediatric infectious disease journal JO - Pediatr. Infect. Dis. J. VL - 29 IS - 9 N2 - BACKGROUND: In the United States, more children are being vaccinated against influenza in August and September, months before peak influenza activity. Sustained vaccine efficacy through 12 months postvaccination has been demonstrated in children for live attenuated influenza vaccine (LAIV) but not trivalent inactivated influenza vaccine (TIV). Three large, randomized studies compared LAIV and TIV efficacy in children, providing the opportunity to examine the impact of time on the relative efficacy of the 2 vaccines. METHODS: For each study, the relative efficacy of LAIV versus TIV was analyzed by time interval (0-4 and >4-8 months postvaccination) for matched and mismatched strains. RESULTS: LAIV recipients had less influenza than TIV recipients during both intervals; the relative efficacy of LAIV versus TIV for matched strains in each study increased from 0 to 4 months (range, 25%-60%) to >4 to 8 months (range, 49%-89%). Analysis of the incidence of individual types/subtypes revealed the same pattern for the predominant matched strain in each study; no consistent pattern was seen for lower-incidence matched strains. For mismatched strains, similar relative efficacy was seen in each time interval. CONCLUSIONS: For matched strains, data suggest that the relative efficacy of LAIV versus TIV in young children increases over time. Consistent with previous studies of TIV-induced immunity, this analysis suggests that the absolute efficacy of TIV against matched strains in children may be lower at >4 to 8 versus 0 to 4 months postvaccination. Relative efficacy against mismatched strains was similar over time, consistent with previous estimates of the absolute efficacies of the vaccines against mismatched strains. Further research is needed to confirm these findings and to characterize the duration of protection provided by TIV in children. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/20458256/The_efficacy_of_live_attenuated_and_inactivated_influenza_vaccines_in_children_as_a_function_of_time_postvaccination_ L2 - http://dx.doi.org/10.1097/INF.0b013e3181e2872f DB - PRIME DP - Unbound Medicine ER -