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Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup.
Acta Gastroenterol Belg. 2010 Jan-Mar; 73(1):12-7.AG

Abstract

BACKGROUND AND STUDY AIMS

The question of whether elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease evident on ultrasonography was investigated by longitudinal approach in Japanese undergoing a health checkup.

PATIENTS AND METHODS

A total of 1,386 male and 3,453 female nondrinkers participating in health checkups in both 2000 and 2005 were included. Multiple logistic regression analyses were performed for 1,042 men (51.4 +/- 11.2 years old) and 3,076 women (51.8 +/- 9.2 years old) to identify independent factors for newly developed nonalcoholic fatty liver disease in 2005. Adjustment was made for age, body mass index, body mass index increase for 5 years, systolic blood pressure, triglyceridemia, fasting blood glucose, and smoking.

RESULTS

The prevalence of nonalcoholic fatty liver disease and body mass index, systolic blood pressure, and triglyceride were significantly higher in the participants with elevated serum uric acid, with a significant increasing trend in relation to serum uric acid quartiles. Nonalcoholic fatty liver disease was newly diagnosed in 17.4% of males and 8.2% of females, respectively, in 2005. Serum uric acid adjusted for other factors was a risk factor for nonalcoholic fatty liver disease in both sexes and quartiles 3 and 4 had significantly elevated risks. The odds ratio and 95% confidence interval for one increment of serum uric acid were 1.31 and 1.11-1.56 in men and 1.30 and 1.10-1.53 in women, respectively.

CONCLUSIONS

Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup.

Authors+Show Affiliations

Okazaki City Medical Association, Public Health Center, 1-9-1 Tatsumi-nishi, Okazaki, Aichi, Japan. t-yamada@okazaki-med.or.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20458845

Citation

Yamada, Tamaki, et al. "Elevated Serum Uric Acid Is an Independent Risk Factor for Nonalcoholic Fatty Liver Disease in Japanese Undergoing a Health Checkup." Acta Gastro-enterologica Belgica, vol. 73, no. 1, 2010, pp. 12-7.
Yamada T, Suzuki S, Fukatsu M, et al. Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup. Acta Gastroenterol Belg. 2010;73(1):12-7.
Yamada, T., Suzuki, S., Fukatsu, M., Wada, T., Yoshida, T., & Joh, T. (2010). Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup. Acta Gastro-enterologica Belgica, 73(1), 12-7.
Yamada T, et al. Elevated Serum Uric Acid Is an Independent Risk Factor for Nonalcoholic Fatty Liver Disease in Japanese Undergoing a Health Checkup. Acta Gastroenterol Belg. 2010 Jan-Mar;73(1):12-7. PubMed PMID: 20458845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup. AU - Yamada,Tamaki, AU - Suzuki,Sadao, AU - Fukatsu,Mitsuru, AU - Wada,Tsuneya, AU - Yoshida,Takashi, AU - Joh,Takashi, PY - 2010/5/13/entrez PY - 2010/5/13/pubmed PY - 2010/7/23/medline SP - 12 EP - 7 JF - Acta gastro-enterologica Belgica JO - Acta Gastroenterol Belg VL - 73 IS - 1 N2 - BACKGROUND AND STUDY AIMS: The question of whether elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease evident on ultrasonography was investigated by longitudinal approach in Japanese undergoing a health checkup. PATIENTS AND METHODS: A total of 1,386 male and 3,453 female nondrinkers participating in health checkups in both 2000 and 2005 were included. Multiple logistic regression analyses were performed for 1,042 men (51.4 +/- 11.2 years old) and 3,076 women (51.8 +/- 9.2 years old) to identify independent factors for newly developed nonalcoholic fatty liver disease in 2005. Adjustment was made for age, body mass index, body mass index increase for 5 years, systolic blood pressure, triglyceridemia, fasting blood glucose, and smoking. RESULTS: The prevalence of nonalcoholic fatty liver disease and body mass index, systolic blood pressure, and triglyceride were significantly higher in the participants with elevated serum uric acid, with a significant increasing trend in relation to serum uric acid quartiles. Nonalcoholic fatty liver disease was newly diagnosed in 17.4% of males and 8.2% of females, respectively, in 2005. Serum uric acid adjusted for other factors was a risk factor for nonalcoholic fatty liver disease in both sexes and quartiles 3 and 4 had significantly elevated risks. The odds ratio and 95% confidence interval for one increment of serum uric acid were 1.31 and 1.11-1.56 in men and 1.30 and 1.10-1.53 in women, respectively. CONCLUSIONS: Elevated serum uric acid is an independent risk factor for nonalcoholic fatty liver disease in Japanese undergoing a health checkup. SN - 1784-3227 UR - https://www.unboundmedicine.com/medline/citation/20458845/Elevated_serum_uric_acid_is_an_independent_risk_factor_for_nonalcoholic_fatty_liver_disease_in_Japanese_undergoing_a_health_checkup_ L2 - https://www.ageb.be/ageb-journal/ageb-volume/ageb-article/838 DB - PRIME DP - Unbound Medicine ER -