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Dopamine on D2-like receptors is involved in reward evaluation in water-deprived rats licking for NaCl and water.
Pharmacol Biochem Behav. 2010 Aug; 96(2):194-7.PB

Abstract

The analysis of licking microstructure provides measures, size and number of licking bouts, which might reveal, respectively, reward evaluation and behavioural activation. Based on the ability of the dopamine D2-like receptor antagonist raclopride to reduce bout size and to induce an "extinction mimicry effect" on bout number, we suggested that the level of activation of reward-associated responses is updated, or "reboosted", on the basis of a dopamine D2-like receptor-mediated evaluation process occurring during the consummatory transaction with the reward. Here we investigate the effects of the dopamine D2-like receptor antagonist raclopride (0, 25, 125, and 250microg/kg) on the microstructure of licking for water and sodium chloride solutions (0.075M, 0.15M, and 0.3M) in 12h water-deprived rats. In each session, rats were exposed to brief contact tests (1min) for each solution. Bout size, but not bout number, was decreased at the highest NaCl concentration. Raclopride reduced lick number owing to reduced bout size, while bout number was either not affected or even increased depending on the dose. These results are in agreement with the previous observations on sucrose licking, and suggest the involvement of dopamine D2-like receptors in an evaluation process occurring during the consummatory transaction with the reward.

Authors+Show Affiliations

Dipartimento di Scienze del Farmaco, Università di Sassari, Sassari, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20460136

Citation

Canu, Maria Elena, et al. "Dopamine On D2-like Receptors Is Involved in Reward Evaluation in Water-deprived Rats Licking for NaCl and Water." Pharmacology, Biochemistry, and Behavior, vol. 96, no. 2, 2010, pp. 194-7.
Canu ME, Carta D, Murgia E, et al. Dopamine on D2-like receptors is involved in reward evaluation in water-deprived rats licking for NaCl and water. Pharmacol Biochem Behav. 2010;96(2):194-7.
Canu, M. E., Carta, D., Murgia, E., Serra, G., & D'Aquila, P. S. (2010). Dopamine on D2-like receptors is involved in reward evaluation in water-deprived rats licking for NaCl and water. Pharmacology, Biochemistry, and Behavior, 96(2), 194-7. https://doi.org/10.1016/j.pbb.2010.05.004
Canu ME, et al. Dopamine On D2-like Receptors Is Involved in Reward Evaluation in Water-deprived Rats Licking for NaCl and Water. Pharmacol Biochem Behav. 2010;96(2):194-7. PubMed PMID: 20460136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dopamine on D2-like receptors is involved in reward evaluation in water-deprived rats licking for NaCl and water. AU - Canu,Maria Elena, AU - Carta,Davide, AU - Murgia,Emanuele, AU - Serra,Gino, AU - D'Aquila,Paolo S, Y1 - 2010/05/09/ PY - 2010/03/14/received PY - 2010/04/18/revised PY - 2010/05/02/accepted PY - 2010/5/13/entrez PY - 2010/5/13/pubmed PY - 2010/10/1/medline SP - 194 EP - 7 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 96 IS - 2 N2 - The analysis of licking microstructure provides measures, size and number of licking bouts, which might reveal, respectively, reward evaluation and behavioural activation. Based on the ability of the dopamine D2-like receptor antagonist raclopride to reduce bout size and to induce an "extinction mimicry effect" on bout number, we suggested that the level of activation of reward-associated responses is updated, or "reboosted", on the basis of a dopamine D2-like receptor-mediated evaluation process occurring during the consummatory transaction with the reward. Here we investigate the effects of the dopamine D2-like receptor antagonist raclopride (0, 25, 125, and 250microg/kg) on the microstructure of licking for water and sodium chloride solutions (0.075M, 0.15M, and 0.3M) in 12h water-deprived rats. In each session, rats were exposed to brief contact tests (1min) for each solution. Bout size, but not bout number, was decreased at the highest NaCl concentration. Raclopride reduced lick number owing to reduced bout size, while bout number was either not affected or even increased depending on the dose. These results are in agreement with the previous observations on sucrose licking, and suggest the involvement of dopamine D2-like receptors in an evaluation process occurring during the consummatory transaction with the reward. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/20460136/Dopamine_on_D2_like_receptors_is_involved_in_reward_evaluation_in_water_deprived_rats_licking_for_NaCl_and_water_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(10)00140-1 DB - PRIME DP - Unbound Medicine ER -