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Hepatocyte growth factor in exhaled breath and BAL fluid in sarcoidosis.
Pneumonol Alergol Pol. 2010; 78(3):187-91.PA

Abstract

INTRODUCTION

Hepatocyte growth factor (HGF) is a strong mitogen stimulating lung epithelial cell growth. Elevated levels of HGF have been reported in various biological materials of patients with acute respiratory distress syndrome and in patients recovering from pneumonia or pneumonectomy. Sarcoidosis may be complicated by lung fibrosis. Consequently, HGF could be considered a new biomarker identifying patients with a higher risk of lung fibrosis. The aim of the study was to verify whether: 1. HGF is measurable in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC); 2. HGF in BALF or EBC is impaired in sarcoidosis; and 3. HGF correlates with chosen activity and prognostic markers.

MATERIAL AND METHODS

Sixty-four EBC and 30 BALF of sarcoid patients, and 15 and 9 of healthy controls, respectively, were collected for the measurement of HGF using an ELISA test.

RESULTS

HGF was detectable in 62% of EBC samples (56% sarcoidosis and 87% of controls) and in all the BALF samples. EBC and BALF concentrations were not different in comparison to the controls. Moreover, no correlation was found between EBC/BALF concentrations and radiological stage, lung function tests, duration of disease, number of relapses, BALF lymphocytes, serum ACE, or serum and urine calcium concentrations.

CONCLUSIONS

HGF is detectable in BAL and EBC. However, it does not distinguish sarcoidosis patients from healthy subjects. The above, as well as the lack of correlations with various parameters of disease activity and severity rule out EBC/ /BALF HGF as a biomarker for sarcoidosis monitoring.

Authors+Show Affiliations

Department of Pneumology and Allergy, Medical University of Lodz, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20461686

Citation

Piotrowski, Wojciech J., et al. "Hepatocyte Growth Factor in Exhaled Breath and BAL Fluid in Sarcoidosis." Pneumonologia I Alergologia Polska, vol. 78, no. 3, 2010, pp. 187-91.
Piotrowski WJ, Kurmanowska Z, Antczak A, et al. Hepatocyte growth factor in exhaled breath and BAL fluid in sarcoidosis. Pneumonol Alergol Pol. 2010;78(3):187-91.
Piotrowski, W. J., Kurmanowska, Z., Antczak, A., Marczak, J., & Górski, P. (2010). Hepatocyte growth factor in exhaled breath and BAL fluid in sarcoidosis. Pneumonologia I Alergologia Polska, 78(3), 187-91.
Piotrowski WJ, et al. Hepatocyte Growth Factor in Exhaled Breath and BAL Fluid in Sarcoidosis. Pneumonol Alergol Pol. 2010;78(3):187-91. PubMed PMID: 20461686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatocyte growth factor in exhaled breath and BAL fluid in sarcoidosis. AU - Piotrowski,Wojciech J, AU - Kurmanowska,Zofia, AU - Antczak,Adam, AU - Marczak,Jerzy, AU - Górski,Paweł, PY - 2010/5/13/entrez PY - 2010/5/13/pubmed PY - 2010/7/14/medline SP - 187 EP - 91 JF - Pneumonologia i alergologia polska JO - Pneumonol Alergol Pol VL - 78 IS - 3 N2 - INTRODUCTION: Hepatocyte growth factor (HGF) is a strong mitogen stimulating lung epithelial cell growth. Elevated levels of HGF have been reported in various biological materials of patients with acute respiratory distress syndrome and in patients recovering from pneumonia or pneumonectomy. Sarcoidosis may be complicated by lung fibrosis. Consequently, HGF could be considered a new biomarker identifying patients with a higher risk of lung fibrosis. The aim of the study was to verify whether: 1. HGF is measurable in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC); 2. HGF in BALF or EBC is impaired in sarcoidosis; and 3. HGF correlates with chosen activity and prognostic markers. MATERIAL AND METHODS: Sixty-four EBC and 30 BALF of sarcoid patients, and 15 and 9 of healthy controls, respectively, were collected for the measurement of HGF using an ELISA test. RESULTS: HGF was detectable in 62% of EBC samples (56% sarcoidosis and 87% of controls) and in all the BALF samples. EBC and BALF concentrations were not different in comparison to the controls. Moreover, no correlation was found between EBC/BALF concentrations and radiological stage, lung function tests, duration of disease, number of relapses, BALF lymphocytes, serum ACE, or serum and urine calcium concentrations. CONCLUSIONS: HGF is detectable in BAL and EBC. However, it does not distinguish sarcoidosis patients from healthy subjects. The above, as well as the lack of correlations with various parameters of disease activity and severity rule out EBC/ /BALF HGF as a biomarker for sarcoidosis monitoring. SN - 0867-7077 UR - https://www.unboundmedicine.com/medline/citation/20461686/Hepatocyte_growth_factor_in_exhaled_breath_and_BAL_fluid_in_sarcoidosis_ L2 - http://czasopisma.viamedica.pl/pap/article/view/27725 DB - PRIME DP - Unbound Medicine ER -