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Characteristics of 250 reproductive-aged polycystic ovary syndrome Thai women at Siriraj Hospital.
J Med Assoc Thai. 2010 Apr; 93(4):399-405.JM

Abstract

OBJECTIVE

To determine the clinical characteristics of reproductive-aged polycystic ovary syndrome (PCOS) Thai women.

STUDY DESIGN

Cross sectional study

SETTINGS

Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital.

SUBJECTS

250 PCOS Thai women who registered at the Siriraj PCOSprojectfrom May 2007 to January 2009. PCOS were diagnosed using Revised Rotterdam 2003 criteria. Women who were taking medications affecting sex hormones or lipid metabolism within 3 months before registration were excluded from the present study.

MATERIAL AND METHOD

Patients were interviewed and examined for weight, height, waist circumference, blood pressure, presence of acanthosis nigricans, and signs of hyperandrogenism. Ovarian ultrasonography was examined using vaginal probe inserting into the vagina or rectum. Venous blood sample of each patient was drawn during 8.00-10.00 o'clock after 12-hour fasting.

MAIN OUTCOME MEASURES

Clinical characteristics and laboratoryprofiles in PCOS Thai women.

RESULTS

Of all participants, 62% were 20-29.9 years old, 30% had high blood pressure, 57% were overweight to obese, 49% had central obesity, and 27% had acanthosis nigricans. Clinical hyperandrogenism was found in 15.6% of the patients. Approximately 7% of PCOS women had impaired fasting glucose and one third had dyslipidemia. Prevalence of the PCOS criteria presenting in the population were oligomenorrhea and/or amenorrhea (98.4%), hyperandrogenism (49 2%), and ultrasonographic polycystic ovary (97.2%). Of all participants, 44% had three components of diagnostic criteria. Among those who had two components, presence of abnormal menstrual cycle plus polycystic ovary was the most common finding.

CONCLUSION

Menstrual problem was the most common presenting symptom among the presented participants. Hyperandrogenism/ -emia adds only a little value on making PCOS diagnosis. Most of the PCOS Thai women have menstrual problem. In these patients, ovarian ultrasonography has high value to diagnose PCOS; addition of androgen blood test can diagnose only 3% more PCOS cases. Although the presented PCOS Thai women are stillyoung, approximately 50% already have some parameters of health risk. It is suggested to provide preventive measures for these patients to prevent long term medical problems.

Authors+Show Affiliations

Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. sitwn@mahidol.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20462080

Citation

Wongwananuruk, Thanyarat, et al. "Characteristics of 250 Reproductive-aged Polycystic Ovary Syndrome Thai Women at Siriraj Hospital." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 93, no. 4, 2010, pp. 399-405.
Wongwananuruk T, Indhavivadhana S, Rattanachaiyanont M, et al. Characteristics of 250 reproductive-aged polycystic ovary syndrome Thai women at Siriraj Hospital. J Med Assoc Thai. 2010;93(4):399-405.
Wongwananuruk, T., Indhavivadhana, S., Rattanachaiyanont, M., Techatraisak, K., Leerasiri, P., Tanmahasamut, P., Angsuwathana, S., & Dangrat, C. (2010). Characteristics of 250 reproductive-aged polycystic ovary syndrome Thai women at Siriraj Hospital. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 93(4), 399-405.
Wongwananuruk T, et al. Characteristics of 250 Reproductive-aged Polycystic Ovary Syndrome Thai Women at Siriraj Hospital. J Med Assoc Thai. 2010;93(4):399-405. PubMed PMID: 20462080.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of 250 reproductive-aged polycystic ovary syndrome Thai women at Siriraj Hospital. AU - Wongwananuruk,Thanyarat, AU - Indhavivadhana,Suchada, AU - Rattanachaiyanont,Manee, AU - Techatraisak,Kitirat, AU - Leerasiri,Pichai, AU - Tanmahasamut,Prasong, AU - Angsuwathana,Surasak, AU - Dangrat,Chongdee, PY - 2010/5/14/entrez PY - 2010/5/14/pubmed PY - 2010/7/23/medline SP - 399 EP - 405 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 93 IS - 4 N2 - OBJECTIVE: To determine the clinical characteristics of reproductive-aged polycystic ovary syndrome (PCOS) Thai women. STUDY DESIGN: Cross sectional study SETTINGS: Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital. SUBJECTS: 250 PCOS Thai women who registered at the Siriraj PCOSprojectfrom May 2007 to January 2009. PCOS were diagnosed using Revised Rotterdam 2003 criteria. Women who were taking medications affecting sex hormones or lipid metabolism within 3 months before registration were excluded from the present study. MATERIAL AND METHOD: Patients were interviewed and examined for weight, height, waist circumference, blood pressure, presence of acanthosis nigricans, and signs of hyperandrogenism. Ovarian ultrasonography was examined using vaginal probe inserting into the vagina or rectum. Venous blood sample of each patient was drawn during 8.00-10.00 o'clock after 12-hour fasting. MAIN OUTCOME MEASURES: Clinical characteristics and laboratoryprofiles in PCOS Thai women. RESULTS: Of all participants, 62% were 20-29.9 years old, 30% had high blood pressure, 57% were overweight to obese, 49% had central obesity, and 27% had acanthosis nigricans. Clinical hyperandrogenism was found in 15.6% of the patients. Approximately 7% of PCOS women had impaired fasting glucose and one third had dyslipidemia. Prevalence of the PCOS criteria presenting in the population were oligomenorrhea and/or amenorrhea (98.4%), hyperandrogenism (49 2%), and ultrasonographic polycystic ovary (97.2%). Of all participants, 44% had three components of diagnostic criteria. Among those who had two components, presence of abnormal menstrual cycle plus polycystic ovary was the most common finding. CONCLUSION: Menstrual problem was the most common presenting symptom among the presented participants. Hyperandrogenism/ -emia adds only a little value on making PCOS diagnosis. Most of the PCOS Thai women have menstrual problem. In these patients, ovarian ultrasonography has high value to diagnose PCOS; addition of androgen blood test can diagnose only 3% more PCOS cases. Although the presented PCOS Thai women are stillyoung, approximately 50% already have some parameters of health risk. It is suggested to provide preventive measures for these patients to prevent long term medical problems. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/20462080/Characteristics_of_250_reproductive_aged_polycystic_ovary_syndrome_Thai_women_at_Siriraj_Hospital_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -