Tags

Type your tag names separated by a space and hit enter

Is there a role for fatty acids in early life programming of the immune system?
Proc Nutr Soc 2010; 69(3):373-80PN

Abstract

There may be a causal relationship between n-6 PUFA intake and allergic disease and there are biologically plausible mechanisms, involving eicosanoid mediators of the n-6 PUFA arachidonic acid, that could explain this. There is some evidence that high linoleic acid intake is linked with increased risk of atopic sensitisation and allergic manifestations. Fish and fish oils are sources of long-chain n-3 PUFA and these fatty acids act to oppose the actions of n-6 PUFA. It is considered that n-3 PUFA will protect against atopic sensitisation and against the clinical manifestations of atopy. All five epidemiological studies investigating the effect of maternal fish intake during pregnancy on atopic or allergic outcomes in infants/children of those pregnancies concluded protective associations. Epidemiological studies investigating the effects of fish intake during infancy and childhood on atopic outcomes in those infants or children are inconsistent, although the majority of the studies (9/14) showed a protective effect of fish. Fish oil provision to pregnant women is associated with immunologic changes in cord blood. Provision of fish oil during pregnancy may reduce sensitisation to common food allergens and reduce the prevalence and severity of atopic dermatitis in the first year of life. This effect may persist until adolescence with a reduction in prevalence and/or severity of eczema, hayfever and asthma. Fish oil supplementation in infancy may decrease the risk of developing some manifestations of allergic disease, but whether this benefit persists as other factors come into play remains to be determined.

Authors+Show Affiliations

Institute of Human Nutrition and Institute of Developmental Sciences, School of Medicine, University of Southampton, IDS Building, MP887 Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK. pcc@soton.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20462467

Citation

Calder, Philip C., et al. "Is There a Role for Fatty Acids in Early Life Programming of the Immune System?" The Proceedings of the Nutrition Society, vol. 69, no. 3, 2010, pp. 373-80.
Calder PC, Kremmyda LS, Vlachava M, et al. Is there a role for fatty acids in early life programming of the immune system? Proc Nutr Soc. 2010;69(3):373-80.
Calder, P. C., Kremmyda, L. S., Vlachava, M., Noakes, P. S., & Miles, E. A. (2010). Is there a role for fatty acids in early life programming of the immune system? The Proceedings of the Nutrition Society, 69(3), pp. 373-80. doi:10.1017/S0029665110001552.
Calder PC, et al. Is There a Role for Fatty Acids in Early Life Programming of the Immune System. Proc Nutr Soc. 2010;69(3):373-80. PubMed PMID: 20462467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there a role for fatty acids in early life programming of the immune system? AU - Calder,Philip C, AU - Kremmyda,Lefkothea-Stella, AU - Vlachava,Maria, AU - Noakes,Paul S, AU - Miles,Elizabeth A, Y1 - 2010/05/13/ PY - 2010/5/14/entrez PY - 2010/5/14/pubmed PY - 2011/2/9/medline SP - 373 EP - 80 JF - The Proceedings of the Nutrition Society JO - Proc Nutr Soc VL - 69 IS - 3 N2 - There may be a causal relationship between n-6 PUFA intake and allergic disease and there are biologically plausible mechanisms, involving eicosanoid mediators of the n-6 PUFA arachidonic acid, that could explain this. There is some evidence that high linoleic acid intake is linked with increased risk of atopic sensitisation and allergic manifestations. Fish and fish oils are sources of long-chain n-3 PUFA and these fatty acids act to oppose the actions of n-6 PUFA. It is considered that n-3 PUFA will protect against atopic sensitisation and against the clinical manifestations of atopy. All five epidemiological studies investigating the effect of maternal fish intake during pregnancy on atopic or allergic outcomes in infants/children of those pregnancies concluded protective associations. Epidemiological studies investigating the effects of fish intake during infancy and childhood on atopic outcomes in those infants or children are inconsistent, although the majority of the studies (9/14) showed a protective effect of fish. Fish oil provision to pregnant women is associated with immunologic changes in cord blood. Provision of fish oil during pregnancy may reduce sensitisation to common food allergens and reduce the prevalence and severity of atopic dermatitis in the first year of life. This effect may persist until adolescence with a reduction in prevalence and/or severity of eczema, hayfever and asthma. Fish oil supplementation in infancy may decrease the risk of developing some manifestations of allergic disease, but whether this benefit persists as other factors come into play remains to be determined. SN - 1475-2719 UR - https://www.unboundmedicine.com/medline/citation/20462467/Is_there_a_role_for_fatty_acids_in_early_life_programming_of_the_immune_system L2 - https://www.cambridge.org/core/product/identifier/S0029665110001552/type/journal_article DB - PRIME DP - Unbound Medicine ER -