Tags

Type your tag names separated by a space and hit enter

Multiple sclerosis and solar exposure before the age of 15 years: case-control study in Cuba, Martinique and Sicily.

Abstract

Few studies report a protective role of childhood solar exposure to multiple sclerosis. Our objective was to confirm the protective role of childhood solar exposure in multiple sclerosis in Cuba, Martinique and Sicily. This was a matched case- control study, and cases met Poser criteria for clinically, laboratory (definite, probable) multiple sclerosis. Controls were resident population, without neurological disorder, living close to cases (within 100 km), matched for sex, age (+/-5 years), residence before age 15. We recruited 551 subjects during a 1-year period (193 cases, Cuba n = 95, Sicily n = 50, Martinique n = 48; 358 controls). Some (89%) met definite clinical multiple sclerosis criteria (relapsing remitting form (with and without sequel) (74%), secondary progressive (21%), primary progressive (5%)). Odds ratios in a uni-variate analysis were: family history of multiple sclerosis (5.1) and autoimmune disorder (4.0); wearing shirt (3.5), hat (2.7), pants (2.4); sun exposure causing sunburn (1.8); sun exposure duration (1 h more/day; weekends 0.91, weekdays 0.86); bare-chested (0.6); water sports (0.2). Independent factors in the multivariate analysis were family history of multiple sclerosis (4.8 (1.50-15.10)), wearing pants under sunlight (1.9 (1.10-3.20)), sun exposure duration (1 h more/ day, weekdays 0.90 (0.85-0.98), weekends 0.93 (0.87-0.99)), water sports (0.23 (0.13-0.40)). We conclude that outdoor leisure activities in addition to sun exposure reports are associated with a reduced multiple sclerosis risk, with evidence of dose response.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Université de Limoges, IFR 145 GEIST, Institut de Neurologie Tropicale, Limoges, France.

    , , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Case-Control Studies
    Cuba
    Female
    Humans
    Male
    Martinique
    Middle Aged
    Multiple Sclerosis
    Sicily
    Sunlight
    Ultraviolet Rays
    Young Adult

    Pub Type(s)

    Journal Article
    Multicenter Study

    Language

    eng

    PubMed ID

    20463038

    Citation

    Dalmay, F, et al. "Multiple Sclerosis and Solar Exposure Before the Age of 15 Years: Case-control Study in Cuba, Martinique and Sicily." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 16, no. 8, 2010, pp. 899-908.
    Dalmay F, Bhalla D, Nicoletti A, et al. Multiple sclerosis and solar exposure before the age of 15 years: case-control study in Cuba, Martinique and Sicily. Mult Scler. 2010;16(8):899-908.
    Dalmay, F., Bhalla, D., Nicoletti, A., Cabrera-Gomez, J. A., Cabre, P., Ruiz, F., ... Preux, P. M. (2010). Multiple sclerosis and solar exposure before the age of 15 years: case-control study in Cuba, Martinique and Sicily. Multiple Sclerosis (Houndmills, Basingstoke, England), 16(8), pp. 899-908. doi:10.1177/1352458510366856.
    Dalmay F, et al. Multiple Sclerosis and Solar Exposure Before the Age of 15 Years: Case-control Study in Cuba, Martinique and Sicily. Mult Scler. 2010;16(8):899-908. PubMed PMID: 20463038.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Multiple sclerosis and solar exposure before the age of 15 years: case-control study in Cuba, Martinique and Sicily. AU - Dalmay,F, AU - Bhalla,D, AU - Nicoletti,A, AU - Cabrera-Gomez,J A, AU - Cabre,P, AU - Ruiz,F, AU - Druet-Cabanac,M, AU - Dumas,M, AU - Preux,P M, Y1 - 2010/05/12/ PY - 2010/5/14/entrez PY - 2010/5/14/pubmed PY - 2010/12/21/medline SP - 899 EP - 908 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult. Scler. VL - 16 IS - 8 N2 - Few studies report a protective role of childhood solar exposure to multiple sclerosis. Our objective was to confirm the protective role of childhood solar exposure in multiple sclerosis in Cuba, Martinique and Sicily. This was a matched case- control study, and cases met Poser criteria for clinically, laboratory (definite, probable) multiple sclerosis. Controls were resident population, without neurological disorder, living close to cases (within 100 km), matched for sex, age (+/-5 years), residence before age 15. We recruited 551 subjects during a 1-year period (193 cases, Cuba n = 95, Sicily n = 50, Martinique n = 48; 358 controls). Some (89%) met definite clinical multiple sclerosis criteria (relapsing remitting form (with and without sequel) (74%), secondary progressive (21%), primary progressive (5%)). Odds ratios in a uni-variate analysis were: family history of multiple sclerosis (5.1) and autoimmune disorder (4.0); wearing shirt (3.5), hat (2.7), pants (2.4); sun exposure causing sunburn (1.8); sun exposure duration (1 h more/day; weekends 0.91, weekdays 0.86); bare-chested (0.6); water sports (0.2). Independent factors in the multivariate analysis were family history of multiple sclerosis (4.8 (1.50-15.10)), wearing pants under sunlight (1.9 (1.10-3.20)), sun exposure duration (1 h more/ day, weekdays 0.90 (0.85-0.98), weekends 0.93 (0.87-0.99)), water sports (0.23 (0.13-0.40)). We conclude that outdoor leisure activities in addition to sun exposure reports are associated with a reduced multiple sclerosis risk, with evidence of dose response. SN - 1477-0970 UR - https://www.unboundmedicine.com/medline/citation/20463038/Multiple_sclerosis_and_solar_exposure_before_the_age_of_15_years:_case_control_study_in_Cuba_Martinique_and_Sicily_ L2 - http://journals.sagepub.com/doi/full/10.1177/1352458510366856?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -