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Meta-analyses of lignans and enterolignans in relation to breast cancer risk.
Am J Clin Nutr 2010; 92(1):141-53AJ

Abstract

BACKGROUND

Epidemiologic studies that examined whether lignans, the most important class of phytoestrogens in the Western diet, protect against breast cancer have yielded inconsistent results.

OBJECTIVE

In this study, we conducted meta-analyses on the association between lignans and breast cancer risk.

DESIGN

We performed a systematic MEDLINE search to identify epidemiologic studies published between 1997 and August 2009. We calculated pooled risk estimates (REs) for total lignan exposure, dietary lignan intake, enterolignan exposure, and blood or urine concentrations of enterolactone and according to menopausal and estrogen receptor (ER) status of tumors.

RESULTS

We included 21 studies (11 prospective cohort studies and 10 case-control studies) in the meta-analyses. Lignan exposure was not associated with an overall breast cancer risk (RE: 0.92; 95% CI: 0.81, 1.02; P for heterogeneity = 0.004). However, in postmenopausal women, high lignan intake was associated with a significant reduced risk of breast cancer (13 studies; RE: 0.86; 95% CI: 0.78, 0.94; P for heterogeneity = 0.32). Breast cancer risk was also inversely associated with enterolignan exposure (4 studies; RE: 0.84; 95% CI: 0.71, 0.97) but not with blood or urine enterolactone concentrations. The associations were not significantly different between ER-status subgroups (6 studies).

CONCLUSIONS

High lignan exposure may be associated with a reduced breast cancer risk in postmenopausal women. Additional work is warranted to clarify the association between lignan exposure and breast cancer risk.

Authors+Show Affiliations

Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20463043

Citation

Buck, Katharina, et al. "Meta-analyses of Lignans and Enterolignans in Relation to Breast Cancer Risk." The American Journal of Clinical Nutrition, vol. 92, no. 1, 2010, pp. 141-53.
Buck K, Zaineddin AK, Vrieling A, et al. Meta-analyses of lignans and enterolignans in relation to breast cancer risk. Am J Clin Nutr. 2010;92(1):141-53.
Buck, K., Zaineddin, A. K., Vrieling, A., Linseisen, J., & Chang-Claude, J. (2010). Meta-analyses of lignans and enterolignans in relation to breast cancer risk. The American Journal of Clinical Nutrition, 92(1), pp. 141-53. doi:10.3945/ajcn.2009.28573.
Buck K, et al. Meta-analyses of Lignans and Enterolignans in Relation to Breast Cancer Risk. Am J Clin Nutr. 2010;92(1):141-53. PubMed PMID: 20463043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meta-analyses of lignans and enterolignans in relation to breast cancer risk. AU - Buck,Katharina, AU - Zaineddin,Aida Karina, AU - Vrieling,Alina, AU - Linseisen,Jakob, AU - Chang-Claude,Jenny, Y1 - 2010/05/12/ PY - 2010/5/14/entrez PY - 2010/5/14/pubmed PY - 2010/7/8/medline SP - 141 EP - 53 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 1 N2 - BACKGROUND: Epidemiologic studies that examined whether lignans, the most important class of phytoestrogens in the Western diet, protect against breast cancer have yielded inconsistent results. OBJECTIVE: In this study, we conducted meta-analyses on the association between lignans and breast cancer risk. DESIGN: We performed a systematic MEDLINE search to identify epidemiologic studies published between 1997 and August 2009. We calculated pooled risk estimates (REs) for total lignan exposure, dietary lignan intake, enterolignan exposure, and blood or urine concentrations of enterolactone and according to menopausal and estrogen receptor (ER) status of tumors. RESULTS: We included 21 studies (11 prospective cohort studies and 10 case-control studies) in the meta-analyses. Lignan exposure was not associated with an overall breast cancer risk (RE: 0.92; 95% CI: 0.81, 1.02; P for heterogeneity = 0.004). However, in postmenopausal women, high lignan intake was associated with a significant reduced risk of breast cancer (13 studies; RE: 0.86; 95% CI: 0.78, 0.94; P for heterogeneity = 0.32). Breast cancer risk was also inversely associated with enterolignan exposure (4 studies; RE: 0.84; 95% CI: 0.71, 0.97) but not with blood or urine enterolactone concentrations. The associations were not significantly different between ER-status subgroups (6 studies). CONCLUSIONS: High lignan exposure may be associated with a reduced breast cancer risk in postmenopausal women. Additional work is warranted to clarify the association between lignan exposure and breast cancer risk. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20463043/Meta_analyses_of_lignans_and_enterolignans_in_relation_to_breast_cancer_risk_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.28573 DB - PRIME DP - Unbound Medicine ER -