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Characteristics, management, and in-hospital outcomes of diabetic acute coronary syndrome patients in Oman.
Saudi Med J. 2010 May; 31(5):520-4.SM

Abstract

OBJECTIVE

To determine clinical characteristics, management, and in-hospital outcomes of diabetic and non-diabetic patients admitted with acute coronary syndrome (ACS) in Oman.

METHODS

Data were analyzed from 1583 consecutive patients admitted to various hospitals in Oman with ACS from May 8 to June 6, 2006, and from January 29 to June 29, 2007, as part of the Gulf RACE (Registry of Acute Coronary Events). The ACS patients were stratified into those with and without diabetes mellitus.

RESULTS

In this study, 588 (37%) patients were diabetic with a mean age of 59 years and included more female than male diabetics (43% versus 33%; p<0.001). Diabetic patients were more likely to present with unstable angina (55% versus 44%; p<0.001) and less likely to present with ST elevation myocardial infarction (20% versus 27%; p=0.001). Both groups received ACS treatment equally; however, diabetic patients were more likely to be treated with glycoprotein IIb/IIIa antagonists and angiotensin-converting enzyme inhibitors or receptor blockers. Diabetic patients experienced more recurrent ischemia (12% versus 8%; p=0.043), heart failure (29% versus 23%; p=0.009), cardiogenic shock (7.5% versus 4.6%; p=0.018), and ventilator requirement (7.3% versus 4.1%; p=0.006). When adjusted for age and gender, diabetes status was an independent risk factor of in-hospital mortality in ACS patients (adjusted odd ratio, 1.68; 95% confidence interval, 1.022.77; p=0.042).

CONCLUSION

Diabetic ACS patients have different clinical characteristics and poorer outcomes. Present treatment strategies are not sufficient to counter the adverse impact of diabetes. More effective and evidence-based therapeutic strategies should be identified and used in diabetic ACS patients.

Authors+Show Affiliations

Department of Cardiology, Royal Hospital, PO Box 1331, Muscat 111, Sultanate of Oman. prashanthp_69@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20464041

Citation

Panduranga, Prashanth, et al. "Characteristics, Management, and In-hospital Outcomes of Diabetic Acute Coronary Syndrome Patients in Oman." Saudi Medical Journal, vol. 31, no. 5, 2010, pp. 520-4.
Panduranga P, Sulaiman KJ, Al-Zakwani IS, et al. Characteristics, management, and in-hospital outcomes of diabetic acute coronary syndrome patients in Oman. Saudi Med J. 2010;31(5):520-4.
Panduranga, P., Sulaiman, K. J., Al-Zakwani, I. S., & Al-Lawati, J. A. (2010). Characteristics, management, and in-hospital outcomes of diabetic acute coronary syndrome patients in Oman. Saudi Medical Journal, 31(5), 520-4.
Panduranga P, et al. Characteristics, Management, and In-hospital Outcomes of Diabetic Acute Coronary Syndrome Patients in Oman. Saudi Med J. 2010;31(5):520-4. PubMed PMID: 20464041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics, management, and in-hospital outcomes of diabetic acute coronary syndrome patients in Oman. AU - Panduranga,Prashanth, AU - Sulaiman,Kadhim J, AU - Al-Zakwani,Ibrahim S, AU - Al-Lawati,Jawad A, PY - 2010/5/14/entrez PY - 2010/5/14/pubmed PY - 2010/10/1/medline SP - 520 EP - 4 JF - Saudi medical journal JO - Saudi Med J VL - 31 IS - 5 N2 - OBJECTIVE: To determine clinical characteristics, management, and in-hospital outcomes of diabetic and non-diabetic patients admitted with acute coronary syndrome (ACS) in Oman. METHODS: Data were analyzed from 1583 consecutive patients admitted to various hospitals in Oman with ACS from May 8 to June 6, 2006, and from January 29 to June 29, 2007, as part of the Gulf RACE (Registry of Acute Coronary Events). The ACS patients were stratified into those with and without diabetes mellitus. RESULTS: In this study, 588 (37%) patients were diabetic with a mean age of 59 years and included more female than male diabetics (43% versus 33%; p<0.001). Diabetic patients were more likely to present with unstable angina (55% versus 44%; p<0.001) and less likely to present with ST elevation myocardial infarction (20% versus 27%; p=0.001). Both groups received ACS treatment equally; however, diabetic patients were more likely to be treated with glycoprotein IIb/IIIa antagonists and angiotensin-converting enzyme inhibitors or receptor blockers. Diabetic patients experienced more recurrent ischemia (12% versus 8%; p=0.043), heart failure (29% versus 23%; p=0.009), cardiogenic shock (7.5% versus 4.6%; p=0.018), and ventilator requirement (7.3% versus 4.1%; p=0.006). When adjusted for age and gender, diabetes status was an independent risk factor of in-hospital mortality in ACS patients (adjusted odd ratio, 1.68; 95% confidence interval, 1.022.77; p=0.042). CONCLUSION: Diabetic ACS patients have different clinical characteristics and poorer outcomes. Present treatment strategies are not sufficient to counter the adverse impact of diabetes. More effective and evidence-based therapeutic strategies should be identified and used in diabetic ACS patients. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/20464041/Characteristics_management_and_in_hospital_outcomes_of_diabetic_acute_coronary_syndrome_patients_in_Oman_ L2 - https://medlineplus.gov/diabetescomplications.html DB - PRIME DP - Unbound Medicine ER -