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Mechanisms of ethanol tolerance in Saccharomyces cerevisiae.
Appl Microbiol Biotechnol. 2010 Jul; 87(3):829-45.AM

Abstract

Saccharomyces cerevisiae is a superb ethanol producer, yet is also sensitive to higher ethanol concentrations especially under high gravity or very high gravity fermentation conditions. Ethanol tolerance is associated with interplay of complex networks at the genome level. Although significant efforts have been made to study ethanol stress response in past decades, mechanisms of ethanol tolerance are not well known. With developments of genome sequencing and genomic technologies, our understanding of yeast biology has been revolutionarily advanced. More evidence of mechanisms of ethanol tolerance have been discovered involving multiple loci, multi-stress, and complex interactions as well as signal transduction pathways and regulatory networks. Transcription dynamics and profiling studies of key gene sets including heat shock proteins provided insight into tolerance mechanisms. A transient gene expression response or a stress response to ethanol does not necessarily lead to ethanol tolerance in yeast. Reprogrammed pathways and interactions of cofactor regeneration and redox balance observed from studies of tolerant yeast demonstrated the significant importance of a time-course study for ethanol tolerance. In this review, we focus on current advances of our understanding for ethanol-tolerance mechanisms of S. cerevisiae including gene expression responses, pathway-based analysis, signal transduction and regulatory networks. A prototype of global system model for mechanisms of ethanol tolerance is presented.

Authors+Show Affiliations

U.S. Department of Agriculture, ARS, Bioenergy Research, National Center for Agricultural Utilization Research, 1815 N University St., Peoria, IL 61604, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

20464391

Citation

Ma, Menggen, and Z Lewis Liu. "Mechanisms of Ethanol Tolerance in Saccharomyces Cerevisiae." Applied Microbiology and Biotechnology, vol. 87, no. 3, 2010, pp. 829-45.
Ma M, Liu ZL. Mechanisms of ethanol tolerance in Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2010;87(3):829-45.
Ma, M., & Liu, Z. L. (2010). Mechanisms of ethanol tolerance in Saccharomyces cerevisiae. Applied Microbiology and Biotechnology, 87(3), 829-45. https://doi.org/10.1007/s00253-010-2594-3
Ma M, Liu ZL. Mechanisms of Ethanol Tolerance in Saccharomyces Cerevisiae. Appl Microbiol Biotechnol. 2010;87(3):829-45. PubMed PMID: 20464391.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of ethanol tolerance in Saccharomyces cerevisiae. AU - Ma,Menggen, AU - Liu,Z Lewis, Y1 - 2010/05/13/ PY - 2010/02/09/received PY - 2010/03/29/accepted PY - 2010/03/29/revised PY - 2010/5/14/entrez PY - 2010/5/14/pubmed PY - 2010/9/21/medline SP - 829 EP - 45 JF - Applied microbiology and biotechnology JO - Appl Microbiol Biotechnol VL - 87 IS - 3 N2 - Saccharomyces cerevisiae is a superb ethanol producer, yet is also sensitive to higher ethanol concentrations especially under high gravity or very high gravity fermentation conditions. Ethanol tolerance is associated with interplay of complex networks at the genome level. Although significant efforts have been made to study ethanol stress response in past decades, mechanisms of ethanol tolerance are not well known. With developments of genome sequencing and genomic technologies, our understanding of yeast biology has been revolutionarily advanced. More evidence of mechanisms of ethanol tolerance have been discovered involving multiple loci, multi-stress, and complex interactions as well as signal transduction pathways and regulatory networks. Transcription dynamics and profiling studies of key gene sets including heat shock proteins provided insight into tolerance mechanisms. A transient gene expression response or a stress response to ethanol does not necessarily lead to ethanol tolerance in yeast. Reprogrammed pathways and interactions of cofactor regeneration and redox balance observed from studies of tolerant yeast demonstrated the significant importance of a time-course study for ethanol tolerance. In this review, we focus on current advances of our understanding for ethanol-tolerance mechanisms of S. cerevisiae including gene expression responses, pathway-based analysis, signal transduction and regulatory networks. A prototype of global system model for mechanisms of ethanol tolerance is presented. SN - 1432-0614 UR - https://www.unboundmedicine.com/medline/citation/20464391/Mechanisms_of_ethanol_tolerance_in_Saccharomyces_cerevisiae_ L2 - https://dx.doi.org/10.1007/s00253-010-2594-3 DB - PRIME DP - Unbound Medicine ER -