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Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature.
J Hepatobiliary Pancreat Sci 2010; 17(3):246-61JH

Abstract

BACKGROUND

Intraductal oncocytic papillary neoplasms (IOPN) are rare tumors of the pancreatic and biliary ductal system. It is not absolutely clear if the molecular and clinicopathologic characteristics of IOPN differ significantly from other related lesions, namely intraductal papillary mucinous neoplasms (IPMN). Therefore it is not clear if it is reasonable to consider IOPN as a separate diagnostic and clinical entity.

METHODS

In order to describe the clinicopathologic characteristics of IOPN and to compare them with the IPMN profile, we performed a systematic review of the literature and additionally studied five previously unreported IOPN cases.

RESULTS

IOPN differ from IPMN by lack of K-ras gene mutations in all studied cases. Several differences in the clinical and biological profile between IOPN and IPMN exist, but they are of quantitative rather than of qualitative nature. Additionally, pancreaticobiliary or gastric-foveolar IPMN components may coexist with IOPN component within a single lesion, which suggests at least a partial relation of the pathogenetic pathways of IPMN and IOPN. Importantly, the pathogenesis of accumulation of mitochondria and oxyphilic appearance of IOPN remains unknown.

CONCLUSIONS

At present, there are no reliable criteria other than histopathological picture and K-ras gene status to differentiate IOPN from IPMN. In particular, no clear differences in optimal treatment options and prognosis between these tumors are known. Further studies are needed to clarify the biology of IOPN and to establish their position in clinicopathologic classifications of pancreatic tumors.

Authors+Show Affiliations

Department of Histopathology, Medical University of Silesia, ul. Medyków 18, 40-754, Katowice, Poland. LLISZKA@MP.PLNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

20464560

Citation

Liszka, Lukasz, et al. "Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Ducts: a Description of Five New Cases and Review Based On a Systematic Survey of the Literature." Journal of Hepato-biliary-pancreatic Sciences, vol. 17, no. 3, 2010, pp. 246-61.
Liszka L, Pajak J, Zielińska-Pajak E, et al. Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature. J Hepatobiliary Pancreat Sci. 2010;17(3):246-61.
Liszka, L., Pajak, J., Zielińska-Pajak, E., Krzych, L., Gołka, D., Mrowiec, S., & Lampe, P. (2010). Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature. Journal of Hepato-biliary-pancreatic Sciences, 17(3), pp. 246-61. doi:10.1007/s00534-010-0268-2.
Liszka L, et al. Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Ducts: a Description of Five New Cases and Review Based On a Systematic Survey of the Literature. J Hepatobiliary Pancreat Sci. 2010;17(3):246-61. PubMed PMID: 20464560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature. AU - Liszka,Lukasz, AU - Pajak,Jacek, AU - Zielińska-Pajak,Ewa, AU - Krzych,Lukasz, AU - Gołka,Dariusz, AU - Mrowiec,Sławomir, AU - Lampe,Paweł, Y1 - 2010/03/04/ PY - 2009/11/09/received PY - 2010/01/12/accepted PY - 2010/5/14/entrez PY - 2010/5/14/pubmed PY - 2010/8/25/medline SP - 246 EP - 61 JF - Journal of hepato-biliary-pancreatic sciences JO - J Hepatobiliary Pancreat Sci VL - 17 IS - 3 N2 - BACKGROUND: Intraductal oncocytic papillary neoplasms (IOPN) are rare tumors of the pancreatic and biliary ductal system. It is not absolutely clear if the molecular and clinicopathologic characteristics of IOPN differ significantly from other related lesions, namely intraductal papillary mucinous neoplasms (IPMN). Therefore it is not clear if it is reasonable to consider IOPN as a separate diagnostic and clinical entity. METHODS: In order to describe the clinicopathologic characteristics of IOPN and to compare them with the IPMN profile, we performed a systematic review of the literature and additionally studied five previously unreported IOPN cases. RESULTS: IOPN differ from IPMN by lack of K-ras gene mutations in all studied cases. Several differences in the clinical and biological profile between IOPN and IPMN exist, but they are of quantitative rather than of qualitative nature. Additionally, pancreaticobiliary or gastric-foveolar IPMN components may coexist with IOPN component within a single lesion, which suggests at least a partial relation of the pathogenetic pathways of IPMN and IOPN. Importantly, the pathogenesis of accumulation of mitochondria and oxyphilic appearance of IOPN remains unknown. CONCLUSIONS: At present, there are no reliable criteria other than histopathological picture and K-ras gene status to differentiate IOPN from IPMN. In particular, no clear differences in optimal treatment options and prognosis between these tumors are known. Further studies are needed to clarify the biology of IOPN and to establish their position in clinicopathologic classifications of pancreatic tumors. SN - 1868-6982 UR - https://www.unboundmedicine.com/medline/citation/20464560/Intraductal_oncocytic_papillary_neoplasms_of_the_pancreas_and_bile_ducts:_a_description_of_five_new_cases_and_review_based_on_a_systematic_survey_of_the_literature_ L2 - https://doi.org/10.1007/s00534-010-0268-2 DB - PRIME DP - Unbound Medicine ER -