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Opium and heroin alter biochemical parameters of human's serum.
Am J Drug Alcohol Abuse. 2010 May; 36(3):135-9.AJ

Abstract

BACKGROUND

Iran is a significant consumer of opium, and, generally, of opioids, in the world. Addiction is one of the important issues of the 21st century and is an imperative issue in Iran. Long-term consumption of opioids affects homeostasis.

OBJECTIVE

To determine the effects of opium and heroin consumption on serum biochemical parameters.

METHODS

In a cross-sectional study, subjects who had consumed heroin (n = 35) or opium (n = 42) for more than two years and 35 nonaddict volunteers as the control group were compared in regard to various biochemical parameters such as fasting blood sugar (FBS), Na(+), K(+), Ca(2+), blood urea nitrogen (BUN), uric acid (UA), triglyceride (TG), cholesterol, creatinine, and total protein. Chromatography was used to confirm opioid consumption, and the concentration of biochemical parameters was determined by laboratory diagnostic tests on serum.

RESULTS

No significant differences were found in Na(+), Ca(2+), BUN, UA, TG, creatinine, and total protein concentrations among the three groups. FBS, K(+), and UA levels were significantly lower in opium addicts compared to the control group. Serum Ca(2+) concentration of heroin addicts showed a significant decrease compared to that of the control group. Both addict groups showed a significant decrease in serum cholesterol levels.

CONCLUSION

Chronic use of opium and heroin can change serum FBS, K(+), Ca(2+), UA, and cholesterol.

SCIENTIFIC SIGNIFICANCE

This study, one of few on the effects of opium on serum biochemical parameters in human subjects, has the potential to contribute to the investigation of new approaches for further basic studies.

Links

Publisher Full Text

Authors+Show Affiliations

Kouros D
Kerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Tahereh H
No affiliation info available
Mohammadreza A
No affiliation info available
Minoo MZ
No affiliation info available

MeSH

AdultBlood GlucoseCalciumCase-Control StudiesCholesterolCross-Sectional StudiesHeroinHumansIranMaleOpioid-Related DisordersOpiumPotassiumUric Acid

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20465370

Citation

Kouros, Divsalar, et al. "Opium and Heroin Alter Biochemical Parameters of Human's Serum." The American Journal of Drug and Alcohol Abuse, vol. 36, no. 3, 2010, pp. 135-9.
Kouros D, Tahereh H, Mohammadreza A, et al. Opium and heroin alter biochemical parameters of human's serum. Am J Drug Alcohol Abuse. 2010;36(3):135-9.
Kouros, D., Tahereh, H., Mohammadreza, A., & Minoo, M. Z. (2010). Opium and heroin alter biochemical parameters of human's serum. The American Journal of Drug and Alcohol Abuse, 36(3), 135-9. https://doi.org/10.3109/00952991003734277
Kouros D, et al. Opium and Heroin Alter Biochemical Parameters of Human's Serum. Am J Drug Alcohol Abuse. 2010;36(3):135-9. PubMed PMID: 20465370.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opium and heroin alter biochemical parameters of human's serum. AU - Kouros,Divsalar, AU - Tahereh,Haghpanah, AU - Mohammadreza,Afarinesh, AU - Minoo,Mahmoudi Zarandi, PY - 2010/5/15/entrez PY - 2010/5/15/pubmed PY - 2010/8/11/medline SP - 135 EP - 9 JF - The American journal of drug and alcohol abuse JO - Am J Drug Alcohol Abuse VL - 36 IS - 3 N2 - BACKGROUND: Iran is a significant consumer of opium, and, generally, of opioids, in the world. Addiction is one of the important issues of the 21st century and is an imperative issue in Iran. Long-term consumption of opioids affects homeostasis. OBJECTIVE: To determine the effects of opium and heroin consumption on serum biochemical parameters. METHODS: In a cross-sectional study, subjects who had consumed heroin (n = 35) or opium (n = 42) for more than two years and 35 nonaddict volunteers as the control group were compared in regard to various biochemical parameters such as fasting blood sugar (FBS), Na(+), K(+), Ca(2+), blood urea nitrogen (BUN), uric acid (UA), triglyceride (TG), cholesterol, creatinine, and total protein. Chromatography was used to confirm opioid consumption, and the concentration of biochemical parameters was determined by laboratory diagnostic tests on serum. RESULTS: No significant differences were found in Na(+), Ca(2+), BUN, UA, TG, creatinine, and total protein concentrations among the three groups. FBS, K(+), and UA levels were significantly lower in opium addicts compared to the control group. Serum Ca(2+) concentration of heroin addicts showed a significant decrease compared to that of the control group. Both addict groups showed a significant decrease in serum cholesterol levels. CONCLUSION: Chronic use of opium and heroin can change serum FBS, K(+), Ca(2+), UA, and cholesterol. SCIENTIFIC SIGNIFICANCE: This study, one of few on the effects of opium on serum biochemical parameters in human subjects, has the potential to contribute to the investigation of new approaches for further basic studies. SN - 1097-9891 UR - https://www.unboundmedicine.com/medline/citation/20465370/Opium_and_heroin_alter_biochemical_parameters_of_human's_serum_ L2 - https://www.tandfonline.com/doi/full/10.3109/00952991003734277 DB - PRIME DP - Unbound Medicine ER -