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Effects of fentanyl-lidocaine-propofol and dexmedetomidine-lidocaine-propofol on tracheal intubation without use of muscle relaxants.
Kaohsiung J Med Sci. 2010 May; 26(5):244-50.KJ

Abstract

The aim of this study was to compare the effects of fentanyl or dexmedetomidine when used in combination with propofol and lidocaine for tracheal intubation without using muscle relaxants. Sixty patients with American Society of Anesthesiologists stage I risk were randomized to receive 1 mg/kg dexmedetomidine (Group D, n = 30) or 2 mg/kg fentanyl (Group F, n = 30), both in combination with 1.5 mg/kg lidocaine and 3 mg/kg propofol. The requirement for intubation was determined based on mask ventilation capability, jaw motility, position of the vocal cords and the patient's response to intubation and inflation of the endotracheal tube cuff. Systolic arterial pressure, mean arterial pressure, heart rate and peripheral oxygen saturation values were also recorded. Rate pressure products were calculated. Jaw relaxation, position of the vocal cords and patient's response to intubation and inflation of the endotracheal tube cuff were significantly better in Group D than in Group F (p < 0.05). The intubation conditions were significantly more satisfactory in Group D than in Group F (p = 0.01). Heart rate was significantly lower in Group D than in Group F after the administration of the study drugs and intubation (p < 0.05). Mean arterial pressure was significantly lower in Group F than in Group D after propofol injection and at 3 and 5 minutes after intubation (p < 0.05). After intubation, the rate pressure product values were significantly lower in Group D than in Group F (p < 0.05). We conclude that endotracheal intubation was better with the dexmedetomidine-lidocaine-propofol combination than with the fentanyl-lidocaine-propofol combination. However, side effects such as bradycardia should be considered when using dexmedetomidine.

Authors+Show Affiliations

Department of Anesthesiology and Reanimation, School of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey. vhanci@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20466334

Citation

Hanci, Volkan, et al. "Effects of Fentanyl-lidocaine-propofol and Dexmedetomidine-lidocaine-propofol On Tracheal Intubation Without Use of Muscle Relaxants." The Kaohsiung Journal of Medical Sciences, vol. 26, no. 5, 2010, pp. 244-50.
Hanci V, Erdoğan G, Okyay RD, et al. Effects of fentanyl-lidocaine-propofol and dexmedetomidine-lidocaine-propofol on tracheal intubation without use of muscle relaxants. Kaohsiung J Med Sci. 2010;26(5):244-50.
Hanci, V., Erdoğan, G., Okyay, R. D., Yurtlu, B. S., Ayoğlu, H., Baydilek, Y., & Turan, I. O. (2010). Effects of fentanyl-lidocaine-propofol and dexmedetomidine-lidocaine-propofol on tracheal intubation without use of muscle relaxants. The Kaohsiung Journal of Medical Sciences, 26(5), 244-50. https://doi.org/10.1016/S1607-551X(10)70035-8
Hanci V, et al. Effects of Fentanyl-lidocaine-propofol and Dexmedetomidine-lidocaine-propofol On Tracheal Intubation Without Use of Muscle Relaxants. Kaohsiung J Med Sci. 2010;26(5):244-50. PubMed PMID: 20466334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of fentanyl-lidocaine-propofol and dexmedetomidine-lidocaine-propofol on tracheal intubation without use of muscle relaxants. AU - Hanci,Volkan, AU - Erdoğan,Gülay, AU - Okyay,Rahşan Dilek, AU - Yurtlu,Bülent Serhan, AU - Ayoğlu,Hilal, AU - Baydilek,Yunus, AU - Turan,Işil Ozkoçak, PY - 2009/03/23/received PY - 2009/12/15/accepted PY - 2010/5/15/entrez PY - 2010/5/15/pubmed PY - 2010/8/24/medline SP - 244 EP - 50 JF - The Kaohsiung journal of medical sciences JO - Kaohsiung J Med Sci VL - 26 IS - 5 N2 - The aim of this study was to compare the effects of fentanyl or dexmedetomidine when used in combination with propofol and lidocaine for tracheal intubation without using muscle relaxants. Sixty patients with American Society of Anesthesiologists stage I risk were randomized to receive 1 mg/kg dexmedetomidine (Group D, n = 30) or 2 mg/kg fentanyl (Group F, n = 30), both in combination with 1.5 mg/kg lidocaine and 3 mg/kg propofol. The requirement for intubation was determined based on mask ventilation capability, jaw motility, position of the vocal cords and the patient's response to intubation and inflation of the endotracheal tube cuff. Systolic arterial pressure, mean arterial pressure, heart rate and peripheral oxygen saturation values were also recorded. Rate pressure products were calculated. Jaw relaxation, position of the vocal cords and patient's response to intubation and inflation of the endotracheal tube cuff were significantly better in Group D than in Group F (p < 0.05). The intubation conditions were significantly more satisfactory in Group D than in Group F (p = 0.01). Heart rate was significantly lower in Group D than in Group F after the administration of the study drugs and intubation (p < 0.05). Mean arterial pressure was significantly lower in Group F than in Group D after propofol injection and at 3 and 5 minutes after intubation (p < 0.05). After intubation, the rate pressure product values were significantly lower in Group D than in Group F (p < 0.05). We conclude that endotracheal intubation was better with the dexmedetomidine-lidocaine-propofol combination than with the fentanyl-lidocaine-propofol combination. However, side effects such as bradycardia should be considered when using dexmedetomidine. SN - 2410-8650 UR - https://www.unboundmedicine.com/medline/citation/20466334/Effects_of_fentanyl_lidocaine_propofol_and_dexmedetomidine_lidocaine_propofol_on_tracheal_intubation_without_use_of_muscle_relaxants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1607-551X(10)70035-8 DB - PRIME DP - Unbound Medicine ER -