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Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder.
Psychiatry Res. 2010 Jun 30; 178(1):112-5.PR

Abstract

Treatment studies have suggested that omega-3 fatty acids (omega-3 FAs) as monotherapy or adjunctive treatment have therapeutic effects in depression. The authors recently reported a study in which fluoxetine and eicosapentaenoic acid (EPA), which is an omega-3 fatty acid, appeared to be equally effective in controlling depressive symptoms and their combination was superior to either of them alone. Regulation of hypothalamus-pituitary-adrenal (HPA) axis activity and reduction of inflammatory cytokines are among several biological mechanisms which potentially explain the impact of omega-3 FAs on depression. In the present study, plasma cortisol and serum interleukin-1beta (IL-1 beta) and interleukin-6 (Il-6) were measured in patients with a diagnosis of major depressive disorder (MDD) participating in aforementioned trial to determine the effects of 8 weeks of treatment of depression with 1000 mg EPA alone or in combination with 20 mg fluoxetine on HPA axis activity and inflammatory cytokine production and compare the changes in these variables with those of treating with 20 mg fluoxetine alone. Forty-two patients were included in analysis. Two-way repeated measures analysis of variance (ANOVA) showed that plasma cortisol decreased significantly after 8 weeks of intervention without significant difference among the groups. There was no interaction between group and response to treatment over time in the cortisol response based on three-way ANOVA. Serum concentrations of IL-1beta and IL-6 did not change significantly after intervention. In conclusion, EPA alone or in combination with fluoxetine, as well as fluoxetine alone decreased serum cortisol after 8 weeks of treatment in patients with major depression disorder (MDD) without any significant effect of response to treatment. Serum IL-1beta and IL-6 did not change significantly after intervention. These findings suggest that EPA may exert its therapeutic effects through reduction of cortisol.

Authors+Show Affiliations

Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20466437

Citation

Jazayeri, Shima, et al. "Effects of Eicosapentaenoic Acid and Fluoxetine On Plasma Cortisol, Serum Interleukin-1beta and Interleukin-6 Concentrations in Patients With Major Depressive Disorder." Psychiatry Research, vol. 178, no. 1, 2010, pp. 112-5.
Jazayeri S, Keshavarz SA, Tehrani-Doost M, et al. Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder. Psychiatry Res. 2010;178(1):112-5.
Jazayeri, S., Keshavarz, S. A., Tehrani-Doost, M., Djalali, M., Hosseini, M., Amini, H., Chamari, M., & Djazayery, A. (2010). Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder. Psychiatry Research, 178(1), 112-5. https://doi.org/10.1016/j.psychres.2009.04.013
Jazayeri S, et al. Effects of Eicosapentaenoic Acid and Fluoxetine On Plasma Cortisol, Serum Interleukin-1beta and Interleukin-6 Concentrations in Patients With Major Depressive Disorder. Psychiatry Res. 2010 Jun 30;178(1):112-5. PubMed PMID: 20466437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder. AU - Jazayeri,Shima, AU - Keshavarz,Seyed A, AU - Tehrani-Doost,Mehdi, AU - Djalali,Mahmood, AU - Hosseini,Mostafa, AU - Amini,Homayoun, AU - Chamari,Maryam, AU - Djazayery,Abolghassem, Y1 - 2010/05/13/ PY - 2008/09/28/received PY - 2009/04/19/revised PY - 2009/04/20/accepted PY - 2010/5/15/entrez PY - 2010/5/15/pubmed PY - 2014/6/4/medline SP - 112 EP - 5 JF - Psychiatry research JO - Psychiatry Res VL - 178 IS - 1 N2 - Treatment studies have suggested that omega-3 fatty acids (omega-3 FAs) as monotherapy or adjunctive treatment have therapeutic effects in depression. The authors recently reported a study in which fluoxetine and eicosapentaenoic acid (EPA), which is an omega-3 fatty acid, appeared to be equally effective in controlling depressive symptoms and their combination was superior to either of them alone. Regulation of hypothalamus-pituitary-adrenal (HPA) axis activity and reduction of inflammatory cytokines are among several biological mechanisms which potentially explain the impact of omega-3 FAs on depression. In the present study, plasma cortisol and serum interleukin-1beta (IL-1 beta) and interleukin-6 (Il-6) were measured in patients with a diagnosis of major depressive disorder (MDD) participating in aforementioned trial to determine the effects of 8 weeks of treatment of depression with 1000 mg EPA alone or in combination with 20 mg fluoxetine on HPA axis activity and inflammatory cytokine production and compare the changes in these variables with those of treating with 20 mg fluoxetine alone. Forty-two patients were included in analysis. Two-way repeated measures analysis of variance (ANOVA) showed that plasma cortisol decreased significantly after 8 weeks of intervention without significant difference among the groups. There was no interaction between group and response to treatment over time in the cortisol response based on three-way ANOVA. Serum concentrations of IL-1beta and IL-6 did not change significantly after intervention. In conclusion, EPA alone or in combination with fluoxetine, as well as fluoxetine alone decreased serum cortisol after 8 weeks of treatment in patients with major depression disorder (MDD) without any significant effect of response to treatment. Serum IL-1beta and IL-6 did not change significantly after intervention. These findings suggest that EPA may exert its therapeutic effects through reduction of cortisol. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/20466437/Effects_of_eicosapentaenoic_acid_and_fluoxetine_on_plasma_cortisol_serum_interleukin_1beta_and_interleukin_6_concentrations_in_patients_with_major_depressive_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(09)00168-1 DB - PRIME DP - Unbound Medicine ER -