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Is hyaluronate sodium effective in the management of knee osteoarthritis? A placebo-controlled double-blind study.
Minerva Med. 2010 Apr; 101(2):63-72.MM

Abstract

AIM

The aim of this study was to investigate the effect of intra-articular hyaluronic acid (HA) injection on pain and function in knee osteoarthritis (OA).

METHODS

Fourty-eight patients with knee OA were included in this study. The patients were randomized into two groups: one group received HA injections (average molecular weight [MW] 1.5 million Da), and the other group received placebo containing 0.9% saline. Three injections of HA or placebo were given at weeks 1, 2 and 3. The evaluation instruments were: Visual Analog Scale (VAS); Likert Scale; Lequesne <ndex; the Western Ontario and McMaster Universities (WOMAC) Index for Osteoarthritis pain, stiffness, and function, and WOMAC pain subgroups (pain on walking, climbing stairs, at night, on sitting and lying down, on standing); the number of analgesics taken; changes in knee flexion angle; and patient satisfaction. Assessment was performed at weeks 1, 3, 5, and 14 after the first injection.

RESULTS

Significant improvement for almost all parameters was noted in both groups (P <0.05). There was no statistically significant difference between change in outcome after HA or placebo treatment (P >0.05), except for WOMAC pain subscore on walking at final assessment (week 14) which showed greater improvement in the HA-treated group (35.2% versus 9.1%; P=0.01).

CONCLUSION

HA treatment was effective in the management of knee OA and improved knee pain and functional outcome, but there was no statistically significant difference in functional and symptom improvement with respect to saline (placebo) injection.

Authors+Show Affiliations

Department of Physical and Rehabilitation Medicine, Camlica Erden Hospital, Istanbul, Turkey. evrenkul@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20467406

Citation

Kul-Panza, E, and N Berker. "Is Hyaluronate Sodium Effective in the Management of Knee Osteoarthritis? a Placebo-controlled Double-blind Study." Minerva Medica, vol. 101, no. 2, 2010, pp. 63-72.
Kul-Panza E, Berker N. Is hyaluronate sodium effective in the management of knee osteoarthritis? A placebo-controlled double-blind study. Minerva Med. 2010;101(2):63-72.
Kul-Panza, E., & Berker, N. (2010). Is hyaluronate sodium effective in the management of knee osteoarthritis? A placebo-controlled double-blind study. Minerva Medica, 101(2), 63-72.
Kul-Panza E, Berker N. Is Hyaluronate Sodium Effective in the Management of Knee Osteoarthritis? a Placebo-controlled Double-blind Study. Minerva Med. 2010;101(2):63-72. PubMed PMID: 20467406.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is hyaluronate sodium effective in the management of knee osteoarthritis? A placebo-controlled double-blind study. AU - Kul-Panza,E, AU - Berker,N, PY - 2010/5/15/entrez PY - 2010/5/15/pubmed PY - 2010/8/17/medline SP - 63 EP - 72 JF - Minerva medica JO - Minerva Med. VL - 101 IS - 2 N2 - AIM: The aim of this study was to investigate the effect of intra-articular hyaluronic acid (HA) injection on pain and function in knee osteoarthritis (OA). METHODS: Fourty-eight patients with knee OA were included in this study. The patients were randomized into two groups: one group received HA injections (average molecular weight [MW] 1.5 million Da), and the other group received placebo containing 0.9% saline. Three injections of HA or placebo were given at weeks 1, 2 and 3. The evaluation instruments were: Visual Analog Scale (VAS); Likert Scale; Lequesne <ndex; the Western Ontario and McMaster Universities (WOMAC) Index for Osteoarthritis pain, stiffness, and function, and WOMAC pain subgroups (pain on walking, climbing stairs, at night, on sitting and lying down, on standing); the number of analgesics taken; changes in knee flexion angle; and patient satisfaction. Assessment was performed at weeks 1, 3, 5, and 14 after the first injection. RESULTS: Significant improvement for almost all parameters was noted in both groups (P <0.05). There was no statistically significant difference between change in outcome after HA or placebo treatment (P >0.05), except for WOMAC pain subscore on walking at final assessment (week 14) which showed greater improvement in the HA-treated group (35.2% versus 9.1%; P=0.01). CONCLUSION: HA treatment was effective in the management of knee OA and improved knee pain and functional outcome, but there was no statistically significant difference in functional and symptom improvement with respect to saline (placebo) injection. SN - 0026-4806 UR - https://www.unboundmedicine.com/medline/citation/20467406/Is_hyaluronate_sodium_effective_in_the_management_of_knee_osteoarthritis_A_placebo_controlled_double_blind_study_ L2 - http://www.minervamedica.it/index2.t?show=R10Y2010N02A0063 DB - PRIME DP - Unbound Medicine ER -