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Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas.

Abstract

CB1 and CB2 receptors are activated by a plethora of cannabinoid compounds, be they endogenously-produced, plant-derived or synthetic. These receptors are expressed by microglia, astrocytes and astrocytomas, and their activation regulates these cells' differentiation, functions and viability. Recent studies show that glial cells also express cannabinoid-like receptors, and that their activation regulates different cell functions, but also control cell viability. This review summarizes this evidence, and discusses how selective compounds targeting cannabinoid-like receptors constitute promising therapeutics to manage neuroinflammation and eradicate malignant astrocytomas. Importantly, the selective targeting of cannabinoid-like receptors should provide therapeutic relieve without inducing the typical psychotropic effects and possible addictive properties associated with the use of Delta9-tetrahydrocannabinol, the main psychotropic ingredient produced by the plant Cannabis sativa.

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  • Authors+Show Affiliations

    Department of Pharmacology, Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195-7280, USA. nstella@u.washington.edu

    Source

    Glia 58:9 2010 Jul pg 1017-30

    MeSH

    Animals
    Astrocytes
    Astrocytoma
    Cannabinoids
    Humans
    Microglia
    Models, Neurological
    Receptor, Cannabinoid, CB1
    Receptor, Cannabinoid, CB2
    Receptors, Cell Surface

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    20468046

    Citation

    Stella, Nephi. "Cannabinoid and Cannabinoid-like Receptors in Microglia, Astrocytes, and Astrocytomas." Glia, vol. 58, no. 9, 2010, pp. 1017-30.
    Stella N. Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. Glia. 2010;58(9):1017-30.
    Stella, N. (2010). Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. Glia, 58(9), pp. 1017-30. doi:10.1002/glia.20983.
    Stella N. Cannabinoid and Cannabinoid-like Receptors in Microglia, Astrocytes, and Astrocytomas. Glia. 2010;58(9):1017-30. PubMed PMID: 20468046.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. A1 - Stella,Nephi, PY - 2010/5/15/entrez PY - 2010/5/15/pubmed PY - 2010/8/27/medline SP - 1017 EP - 30 JF - Glia JO - Glia VL - 58 IS - 9 N2 - CB1 and CB2 receptors are activated by a plethora of cannabinoid compounds, be they endogenously-produced, plant-derived or synthetic. These receptors are expressed by microglia, astrocytes and astrocytomas, and their activation regulates these cells' differentiation, functions and viability. Recent studies show that glial cells also express cannabinoid-like receptors, and that their activation regulates different cell functions, but also control cell viability. This review summarizes this evidence, and discusses how selective compounds targeting cannabinoid-like receptors constitute promising therapeutics to manage neuroinflammation and eradicate malignant astrocytomas. Importantly, the selective targeting of cannabinoid-like receptors should provide therapeutic relieve without inducing the typical psychotropic effects and possible addictive properties associated with the use of Delta9-tetrahydrocannabinol, the main psychotropic ingredient produced by the plant Cannabis sativa. SN - 1098-1136 UR - https://www.unboundmedicine.com/medline/citation/20468046/Cannabinoid_and_cannabinoid_like_receptors_in_microglia_astrocytes_and_astrocytomas_ L2 - https://doi.org/10.1002/glia.20983 DB - PRIME DP - Unbound Medicine ER -