Tags

Type your tag names separated by a space and hit enter

[Primary amyloidosis associated with kappa light chain myeloma].
Acta Med Port. 2010 Mar-Apr; 23(2):281-4.AM

Abstract

INTRODUCTION

The clinical spectrum of plasma cell dyscrasias includes primary amyloidosis and multiple myeloma. These two entities are present at the time of diagnosis in 10 percent of cases.

CASE REPORT

A 72 years old female was admitted to our Institution with oligoanuric renal failure. Renal ultrasonography revealed normal kidney dimensions, with a slight decrease in the normal parenchyma-sinus differentiation. The complementary study identified free kappa light chains in urine (73,9 mg/dL) and bone marrow study fulfilled the criteria for multiple myeloma. Search for amyloid fibrils in abdominal subcutaneous fat was positive. The serum beta-2 microglobulin level was elevated (26 mg/L). Transthoracic echocardiogram did not reveal pathologic findings. Treatment initiation was complicated by hemodialysis catheter-associated Staphylococcus aureus infection.

DISCUSSION

Primary amyloidosis associated with light chain myeloma is a rare, and often late, diagnosis with a dismal prognosis. Renal failure is a frequent initial presentation of the disease and infection an important cause of death.

Authors+Show Affiliations

Serviço de Endocrinologia, Instituto Português de Oncologia do Porto, Porto.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

por

PubMed ID

20470479

Citation

Martins, Raquel G., et al. "[Primary Amyloidosis Associated With Kappa Light Chain Myeloma]." Acta Medica Portuguesa, vol. 23, no. 2, 2010, pp. 281-4.
Martins RG, Roncon-Albuquerque R, Cabral R, et al. [Primary amyloidosis associated with kappa light chain myeloma]. Acta Med Port. 2010;23(2):281-4.
Martins, R. G., Roncon-Albuquerque, R., Cabral, R., Frazão, J., & Von Hafe, P. (2010). [Primary amyloidosis associated with kappa light chain myeloma]. Acta Medica Portuguesa, 23(2), 281-4.
Martins RG, et al. [Primary Amyloidosis Associated With Kappa Light Chain Myeloma]. Acta Med Port. 2010 Mar-Apr;23(2):281-4. PubMed PMID: 20470479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Primary amyloidosis associated with kappa light chain myeloma]. AU - Martins,Raquel G, AU - Roncon-Albuquerque,Roberto,Jr AU - Cabral,Raquel, AU - Frazão,João, AU - Von Hafe,Pedro, Y1 - 2010/04/14/ PY - 2008/08/07/received PY - 2008/10/11/accepted PY - 2010/5/18/entrez PY - 2010/5/18/pubmed PY - 2010/9/2/medline SP - 281 EP - 4 JF - Acta medica portuguesa JO - Acta Med Port VL - 23 IS - 2 N2 - INTRODUCTION: The clinical spectrum of plasma cell dyscrasias includes primary amyloidosis and multiple myeloma. These two entities are present at the time of diagnosis in 10 percent of cases. CASE REPORT: A 72 years old female was admitted to our Institution with oligoanuric renal failure. Renal ultrasonography revealed normal kidney dimensions, with a slight decrease in the normal parenchyma-sinus differentiation. The complementary study identified free kappa light chains in urine (73,9 mg/dL) and bone marrow study fulfilled the criteria for multiple myeloma. Search for amyloid fibrils in abdominal subcutaneous fat was positive. The serum beta-2 microglobulin level was elevated (26 mg/L). Transthoracic echocardiogram did not reveal pathologic findings. Treatment initiation was complicated by hemodialysis catheter-associated Staphylococcus aureus infection. DISCUSSION: Primary amyloidosis associated with light chain myeloma is a rare, and often late, diagnosis with a dismal prognosis. Renal failure is a frequent initial presentation of the disease and infection an important cause of death. SN - 1646-0758 UR - https://www.unboundmedicine.com/medline/citation/20470479/[Primary_amyloidosis_associated_with_kappa_light_chain_myeloma]_ L2 - http://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/603/287 DB - PRIME DP - Unbound Medicine ER -