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Salicylic acid protects against chronic L-DOPA-induced 6-OHDA generation in experimental model of parkinsonism.
Brain Res. 2010 Jul 16; 1344:192-9.BR

Abstract

The present study evaluated the ability of salicylic acid (SA) to attenuate long-term L-DOPA-induced 6-hydroxydopamine (6-OHDA) formation in the striatum of mice, and to protect against the resulting dopaminergic neurotoxicity. The production of 6-OHDA from dopamine in vitro from ferrous-ascorbate-dopamine (FAD) hydroxyl radical ((*)OH) generating system or in vivo in the striatum following prolonged administration of L-DOPA in mice were found to be significantly attenuated by SA. Intra-median forebrain bundle infusion of FAD, but not equivalent dose of ferrous ion or dopamine individually, caused significant striatal dopamine depletion, which was blocked by SA administration. The dose- and time-dependent increase in the formation of 6-OHDA following L-DOPA treatment in the mouse striatum was synergistically enhanced to the systemic administration of the parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. SA treatment significantly attenuated the L-DOPA plus the parkinsonian neurotoxin-induced striatal 6-OHDA generation, and protected against striatal dopamine loss. The present study demonstrated a novel mode of dopaminergic neuroprotection by SA and its possible therapeutic implication in the treatment of Parkinson's disease.

Authors+Show Affiliations

Division of Cell Biology and Physiology, Laboratory of Clinical & Experimental Neuroscience, Indian Institute of Chemical Biology CSIR, 4 Raja S C Mullick Road, Kolkata 700032, West Bengal, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20470760

Citation

Borah, Anupom, and Kochupurackal P. Mohanakumar. "Salicylic Acid Protects Against Chronic L-DOPA-induced 6-OHDA Generation in Experimental Model of Parkinsonism." Brain Research, vol. 1344, 2010, pp. 192-9.
Borah A, Mohanakumar KP. Salicylic acid protects against chronic L-DOPA-induced 6-OHDA generation in experimental model of parkinsonism. Brain Res. 2010;1344:192-9.
Borah, A., & Mohanakumar, K. P. (2010). Salicylic acid protects against chronic L-DOPA-induced 6-OHDA generation in experimental model of parkinsonism. Brain Research, 1344, 192-9. https://doi.org/10.1016/j.brainres.2010.05.010
Borah A, Mohanakumar KP. Salicylic Acid Protects Against Chronic L-DOPA-induced 6-OHDA Generation in Experimental Model of Parkinsonism. Brain Res. 2010 Jul 16;1344:192-9. PubMed PMID: 20470760.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salicylic acid protects against chronic L-DOPA-induced 6-OHDA generation in experimental model of parkinsonism. AU - Borah,Anupom, AU - Mohanakumar,Kochupurackal P, Y1 - 2010/05/12/ PY - 2010/02/17/received PY - 2010/05/01/revised PY - 2010/05/04/accepted PY - 2010/5/18/entrez PY - 2010/5/18/pubmed PY - 2011/1/11/medline SP - 192 EP - 9 JF - Brain research JO - Brain Res VL - 1344 N2 - The present study evaluated the ability of salicylic acid (SA) to attenuate long-term L-DOPA-induced 6-hydroxydopamine (6-OHDA) formation in the striatum of mice, and to protect against the resulting dopaminergic neurotoxicity. The production of 6-OHDA from dopamine in vitro from ferrous-ascorbate-dopamine (FAD) hydroxyl radical ((*)OH) generating system or in vivo in the striatum following prolonged administration of L-DOPA in mice were found to be significantly attenuated by SA. Intra-median forebrain bundle infusion of FAD, but not equivalent dose of ferrous ion or dopamine individually, caused significant striatal dopamine depletion, which was blocked by SA administration. The dose- and time-dependent increase in the formation of 6-OHDA following L-DOPA treatment in the mouse striatum was synergistically enhanced to the systemic administration of the parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. SA treatment significantly attenuated the L-DOPA plus the parkinsonian neurotoxin-induced striatal 6-OHDA generation, and protected against striatal dopamine loss. The present study demonstrated a novel mode of dopaminergic neuroprotection by SA and its possible therapeutic implication in the treatment of Parkinson's disease. SN - 1872-6240 UR - https://www.unboundmedicine.com/medline/citation/20470760/Salicylic_acid_protects_against_chronic_L_DOPA_induced_6_OHDA_generation_in_experimental_model_of_parkinsonism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(10)01089-9 DB - PRIME DP - Unbound Medicine ER -