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Serum glycated albumin levels, but not glycated hemoglobin, is low in relation to glycemia in non-diabetic men with nonalcoholic fatty liver disease with high alanine aminotransferase levels.
Clin Biochem. 2010 Aug; 43(12):1023-5.CB

Abstract

OBJECTIVES

We have reported that serum glycated albumin (GA) levels are low in obese subjects, smokers and hyperuricemic subjects in whom high sensitive CRP (hs-CRP) is elevated. Because patients with nonalcoholic fatty liver disease with high alanine aminotransferase (ALT) levels are reported to show high levels of hs-CRP, the relationship between serum ALT and serum GA levels was investigated.

DESIGN AND METHODS

This study comprised 196 non-diabetic men without drinking habit.

RESULTS

Compared with the normal ALT group (serum ALT < or =30 U/L; n=158), the high ALT group (serum ALT >30 U/L; n=38) had significantly higher fasting plasma glucose (PG), OGTT 2-h PG and HbA(1C) levels. Meanwhile, serum GA was significantly lower, and hs-CRP was significantly higher in the high ALT group.

CONCLUSIONS

The results obtained indicate that serum GA is under a negative control of hs-CRP in subjects with high ALT without drinking habit.

Authors+Show Affiliations

Department of Internal Medicine, Kinki Central Hospital, Hyogo, Japan. koga_m@kich.itami.hyogo.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20470767

Citation

Koga, Masafumi, et al. "Serum Glycated Albumin Levels, but Not Glycated Hemoglobin, Is Low in Relation to Glycemia in Non-diabetic Men With Nonalcoholic Fatty Liver Disease With High Alanine Aminotransferase Levels." Clinical Biochemistry, vol. 43, no. 12, 2010, pp. 1023-5.
Koga M, Murai J, Saito H, et al. Serum glycated albumin levels, but not glycated hemoglobin, is low in relation to glycemia in non-diabetic men with nonalcoholic fatty liver disease with high alanine aminotransferase levels. Clin Biochem. 2010;43(12):1023-5.
Koga, M., Murai, J., Saito, H., Mukai, M., & Kasayama, S. (2010). Serum glycated albumin levels, but not glycated hemoglobin, is low in relation to glycemia in non-diabetic men with nonalcoholic fatty liver disease with high alanine aminotransferase levels. Clinical Biochemistry, 43(12), 1023-5. https://doi.org/10.1016/j.clinbiochem.2010.05.003
Koga M, et al. Serum Glycated Albumin Levels, but Not Glycated Hemoglobin, Is Low in Relation to Glycemia in Non-diabetic Men With Nonalcoholic Fatty Liver Disease With High Alanine Aminotransferase Levels. Clin Biochem. 2010;43(12):1023-5. PubMed PMID: 20470767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum glycated albumin levels, but not glycated hemoglobin, is low in relation to glycemia in non-diabetic men with nonalcoholic fatty liver disease with high alanine aminotransferase levels. AU - Koga,Masafumi, AU - Murai,Jun, AU - Saito,Hiroshi, AU - Mukai,Mikio, AU - Kasayama,Soji, Y1 - 2010/05/12/ PY - 2010/02/26/received PY - 2010/04/20/revised PY - 2010/05/01/accepted PY - 2010/5/18/entrez PY - 2010/5/18/pubmed PY - 2010/10/12/medline SP - 1023 EP - 5 JF - Clinical biochemistry JO - Clin Biochem VL - 43 IS - 12 N2 - OBJECTIVES: We have reported that serum glycated albumin (GA) levels are low in obese subjects, smokers and hyperuricemic subjects in whom high sensitive CRP (hs-CRP) is elevated. Because patients with nonalcoholic fatty liver disease with high alanine aminotransferase (ALT) levels are reported to show high levels of hs-CRP, the relationship between serum ALT and serum GA levels was investigated. DESIGN AND METHODS: This study comprised 196 non-diabetic men without drinking habit. RESULTS: Compared with the normal ALT group (serum ALT < or =30 U/L; n=158), the high ALT group (serum ALT >30 U/L; n=38) had significantly higher fasting plasma glucose (PG), OGTT 2-h PG and HbA(1C) levels. Meanwhile, serum GA was significantly lower, and hs-CRP was significantly higher in the high ALT group. CONCLUSIONS: The results obtained indicate that serum GA is under a negative control of hs-CRP in subjects with high ALT without drinking habit. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/20470767/Serum_glycated_albumin_levels_but_not_glycated_hemoglobin_is_low_in_relation_to_glycemia_in_non_diabetic_men_with_nonalcoholic_fatty_liver_disease_with_high_alanine_aminotransferase_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(10)00210-9 DB - PRIME DP - Unbound Medicine ER -