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Are cannabis use disorders associated with an earlier age at onset of psychosis? A study in first episode schizophrenia.
Schizophr Res 2010; 120(1-3):101-7SR

Abstract

INTRODUCTION

The purpose of this study is to determine if an earlier age at onset of positive symptoms in schizophrenia is associated with cannabis use disorders (CUD).

METHODS

49 first-episode schizophrenia subjects with CUD were compared to 51 first-episode schizophrenia subjects with no substance use disorders for demographic and clinical variables. A multivariate logistic regression was performed to determine the joint relationship between variables significantly associated with CUD on univariate testing and ascertain if these variables independently predict CUD. Significance level was set at p<0.05.

RESULTS

74% of CUD subjects had the onset of CUD before the onset of positive symptoms. Compared to non-substance abusing subjects, CUD subjects were predominantly male, younger at study entry, had an earlier age at onset of positive symptoms, less educational attainment, a lower self-socioeconomic status, better premorbid childhood social adjustment, a trend for poorer premorbid childhood academic adjustment, less motor abnormalities but more severe hallucinations and delusions. In the multivariate analysis, only male gender, worse socio-economic status, better premorbid childhood social adjustment, and more severe positive symptoms at study entry were associated with a lifetime history of CUD.

DISCUSSION

Although cannabis use precedes the onset of illness in most patients, there was no significant association between onset of illness and CUD that was not accounted for by demographic and clinical variables. Previous studies implicating CUD in the onset of schizophrenia may need to more comprehensively assess the relationship between CUD and schizophrenia, and take into account additional variables that we found associated with CUD.

Authors+Show Affiliations

The Zucker Hillside Hospital of the North Shore Long Island Jewish Health System, Psychiatry Research, Glen Oaks, NY 11004, USA. Sevy@lij.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20471224

Citation

Sevy, Serge, et al. "Are Cannabis Use Disorders Associated With an Earlier Age at Onset of Psychosis? a Study in First Episode Schizophrenia." Schizophrenia Research, vol. 120, no. 1-3, 2010, pp. 101-7.
Sevy S, Robinson DG, Napolitano B, et al. Are cannabis use disorders associated with an earlier age at onset of psychosis? A study in first episode schizophrenia. Schizophr Res. 2010;120(1-3):101-7.
Sevy, S., Robinson, D. G., Napolitano, B., Patel, R. C., Gunduz-Bruce, H., Miller, R., ... Kane, J. (2010). Are cannabis use disorders associated with an earlier age at onset of psychosis? A study in first episode schizophrenia. Schizophrenia Research, 120(1-3), pp. 101-7. doi:10.1016/j.schres.2010.03.037.
Sevy S, et al. Are Cannabis Use Disorders Associated With an Earlier Age at Onset of Psychosis? a Study in First Episode Schizophrenia. Schizophr Res. 2010;120(1-3):101-7. PubMed PMID: 20471224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are cannabis use disorders associated with an earlier age at onset of psychosis? A study in first episode schizophrenia. AU - Sevy,Serge, AU - Robinson,Delbert G, AU - Napolitano,Barbara, AU - Patel,Raman C, AU - Gunduz-Bruce,Handan, AU - Miller,Rachel, AU - McCormack,Joanne, AU - Lorell,Beth S, AU - Kane,John, Y1 - 2010/05/14/ PY - 2010/01/15/received PY - 2010/03/23/revised PY - 2010/03/26/accepted PY - 2010/5/18/entrez PY - 2010/5/18/pubmed PY - 2010/10/21/medline SP - 101 EP - 7 JF - Schizophrenia research JO - Schizophr. Res. VL - 120 IS - 1-3 N2 - INTRODUCTION: The purpose of this study is to determine if an earlier age at onset of positive symptoms in schizophrenia is associated with cannabis use disorders (CUD). METHODS: 49 first-episode schizophrenia subjects with CUD were compared to 51 first-episode schizophrenia subjects with no substance use disorders for demographic and clinical variables. A multivariate logistic regression was performed to determine the joint relationship between variables significantly associated with CUD on univariate testing and ascertain if these variables independently predict CUD. Significance level was set at p<0.05. RESULTS: 74% of CUD subjects had the onset of CUD before the onset of positive symptoms. Compared to non-substance abusing subjects, CUD subjects were predominantly male, younger at study entry, had an earlier age at onset of positive symptoms, less educational attainment, a lower self-socioeconomic status, better premorbid childhood social adjustment, a trend for poorer premorbid childhood academic adjustment, less motor abnormalities but more severe hallucinations and delusions. In the multivariate analysis, only male gender, worse socio-economic status, better premorbid childhood social adjustment, and more severe positive symptoms at study entry were associated with a lifetime history of CUD. DISCUSSION: Although cannabis use precedes the onset of illness in most patients, there was no significant association between onset of illness and CUD that was not accounted for by demographic and clinical variables. Previous studies implicating CUD in the onset of schizophrenia may need to more comprehensively assess the relationship between CUD and schizophrenia, and take into account additional variables that we found associated with CUD. SN - 1573-2509 UR - https://www.unboundmedicine.com/medline/citation/20471224/Are_cannabis_use_disorders_associated_with_an_earlier_age_at_onset_of_psychosis_A_study_in_first_episode_schizophrenia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(10)01208-9 DB - PRIME DP - Unbound Medicine ER -