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Interpenetrating polymer network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid.
Int J Biol Macromol. 2010 Aug 01; 47(2):171-9.IJ

Abstract

Glutaraldehyde crosslinked interpenetrating polymer network (IPN) blend microspheres of chitosan (CS) and hydroxyethyl cellulose (HEC) were prepared in the form of microspheres (66-82 microm dia) and investigated for the controlled release (CR) of isoniazid (INH), an antituberculosis drug. Microspheres were characterized by X-ray diffraction (XRD) to study the uniform distribution of drug in the matrices, differential scanning calorimetry (DSC) and thermogravimetry (TGA) to study thermal stabilities of IPN blends. Fourier transform infrared (FTIR) spectroscopy was used to understand chemical interactions and to assess the IPN structure. Scanning electron microscopy (SEM) was employed to investigate the morphology of microspheres. Drug-loaded microspheres were produced in spherical shapes with encapsulation efficiency ranging from 50 to 66%. Equilibrium swelling measured in pH 7.4 buffer solution as well as in vitro release of drug in pH 1.2 and 7.4 buffer solutions indicated the dependence of drug release on crosslinking as well as blend composition of the IPN matrix.

Authors+Show Affiliations

Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580 003, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20471411

Citation

Angadi, Sudha C., et al. "Interpenetrating Polymer Network Blend Microspheres of Chitosan and Hydroxyethyl Cellulose for Controlled Release of Isoniazid." International Journal of Biological Macromolecules, vol. 47, no. 2, 2010, pp. 171-9.
Angadi SC, Manjeshwar LS, Aminabhavi TM. Interpenetrating polymer network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid. Int J Biol Macromol. 2010;47(2):171-9.
Angadi, S. C., Manjeshwar, L. S., & Aminabhavi, T. M. (2010). Interpenetrating polymer network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid. International Journal of Biological Macromolecules, 47(2), 171-9. https://doi.org/10.1016/j.ijbiomac.2010.05.003
Angadi SC, Manjeshwar LS, Aminabhavi TM. Interpenetrating Polymer Network Blend Microspheres of Chitosan and Hydroxyethyl Cellulose for Controlled Release of Isoniazid. Int J Biol Macromol. 2010 Aug 1;47(2):171-9. PubMed PMID: 20471411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interpenetrating polymer network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid. AU - Angadi,Sudha C, AU - Manjeshwar,Lata S, AU - Aminabhavi,Tejraj M, Y1 - 2010/05/13/ PY - 2010/02/09/received PY - 2010/05/03/revised PY - 2010/05/05/accepted PY - 2010/5/18/entrez PY - 2010/5/18/pubmed PY - 2010/10/14/medline SP - 171 EP - 9 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 47 IS - 2 N2 - Glutaraldehyde crosslinked interpenetrating polymer network (IPN) blend microspheres of chitosan (CS) and hydroxyethyl cellulose (HEC) were prepared in the form of microspheres (66-82 microm dia) and investigated for the controlled release (CR) of isoniazid (INH), an antituberculosis drug. Microspheres were characterized by X-ray diffraction (XRD) to study the uniform distribution of drug in the matrices, differential scanning calorimetry (DSC) and thermogravimetry (TGA) to study thermal stabilities of IPN blends. Fourier transform infrared (FTIR) spectroscopy was used to understand chemical interactions and to assess the IPN structure. Scanning electron microscopy (SEM) was employed to investigate the morphology of microspheres. Drug-loaded microspheres were produced in spherical shapes with encapsulation efficiency ranging from 50 to 66%. Equilibrium swelling measured in pH 7.4 buffer solution as well as in vitro release of drug in pH 1.2 and 7.4 buffer solutions indicated the dependence of drug release on crosslinking as well as blend composition of the IPN matrix. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/20471411/Interpenetrating_polymer_network_blend_microspheres_of_chitosan_and_hydroxyethyl_cellulose_for_controlled_release_of_isoniazid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(10)00157-1 DB - PRIME DP - Unbound Medicine ER -