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Corticotropin-releasing hormone and arginine vasopressin in depression focus on the human postmortem hypothalamus.
Vitam Horm 2010; 82:339-65VH

Abstract

The neuropeptides corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are crucially involved in the pathogenesis of depression. The close correlation between the etiology of depression and dysregulation of the stress responses is based upon a hyperactivity of the hypothalamo-pituitary-adrenal (HPA) axis. CRH neurons in the paraventricular nucleus are the motor of the HPA-axis. Centrally released CRH, AVP, and increased levels of cortisol all contribute to the signs and symptoms of depression. Single-nucleotide polymorphisms in the CRH and AVP receptor genes are associated with the risk for depression. Activation of the HPA-axis is generally regarded to be the final common pathway of the pathogenesis of depression. Sex hormones are crucially involved in the regulation of CRH gene expression. The decreased activity of the biological clock, the suprachiasmatic nucleus, as indicated by its lower AVP expression, is the basis for the disturbed rhythms in depression. Both similarities and differences are found in the activity changes in the CRH and AVP systems in depressive disorders and depression in Alzheimer's disease.

Authors+Show Affiliations

Department of Neurobiology, Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20472147

Citation

Bao, Ai-Min, and Dick F. Swaab. "Corticotropin-releasing Hormone and Arginine Vasopressin in Depression Focus On the Human Postmortem Hypothalamus." Vitamins and Hormones, vol. 82, 2010, pp. 339-65.
Bao AM, Swaab DF. Corticotropin-releasing hormone and arginine vasopressin in depression focus on the human postmortem hypothalamus. Vitam Horm. 2010;82:339-65.
Bao, A. M., & Swaab, D. F. (2010). Corticotropin-releasing hormone and arginine vasopressin in depression focus on the human postmortem hypothalamus. Vitamins and Hormones, 82, pp. 339-65. doi:10.1016/S0083-6729(10)82018-7.
Bao AM, Swaab DF. Corticotropin-releasing Hormone and Arginine Vasopressin in Depression Focus On the Human Postmortem Hypothalamus. Vitam Horm. 2010;82:339-65. PubMed PMID: 20472147.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Corticotropin-releasing hormone and arginine vasopressin in depression focus on the human postmortem hypothalamus. AU - Bao,Ai-Min, AU - Swaab,Dick F, PY - 2010/5/18/entrez PY - 2010/5/18/pubmed PY - 2010/8/21/medline SP - 339 EP - 65 JF - Vitamins and hormones JO - Vitam. Horm. VL - 82 N2 - The neuropeptides corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are crucially involved in the pathogenesis of depression. The close correlation between the etiology of depression and dysregulation of the stress responses is based upon a hyperactivity of the hypothalamo-pituitary-adrenal (HPA) axis. CRH neurons in the paraventricular nucleus are the motor of the HPA-axis. Centrally released CRH, AVP, and increased levels of cortisol all contribute to the signs and symptoms of depression. Single-nucleotide polymorphisms in the CRH and AVP receptor genes are associated with the risk for depression. Activation of the HPA-axis is generally regarded to be the final common pathway of the pathogenesis of depression. Sex hormones are crucially involved in the regulation of CRH gene expression. The decreased activity of the biological clock, the suprachiasmatic nucleus, as indicated by its lower AVP expression, is the basis for the disturbed rhythms in depression. Both similarities and differences are found in the activity changes in the CRH and AVP systems in depressive disorders and depression in Alzheimer's disease. SN - 0083-6729 UR - https://www.unboundmedicine.com/medline/citation/20472147/Corticotropin_releasing_hormone_and_arginine_vasopressin_in_depression_focus_on_the_human_postmortem_hypothalamus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0083-6729(10)82018-7 DB - PRIME DP - Unbound Medicine ER -