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Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome.
Arch Gynecol Obstet. 2010 Oct; 282(4):439-43.AG

Abstract

OBJECTIVE

To compare the efficacy of metformin and clomiphene citrate (CC) therapies for ovulation induction in anovulatory infertile women with polycystic ovary syndrome (PCOS).

METHODS

A total of 69 consecutive infertile, anovulatory women with PCOS were enrolled in this prospective, non-randomized trial. The women were prescribed either 1,700 mg/day metformin or CC with a starting dose of 50 mg/day up to 150 mg/day for a period of six consecutive cycles.

RESULTS

Metformin and CC groups were followed for a total of 136 and 94 cycles, respectively. Metformin group had lower rates of ovulation when compared with CC group (32.3 vs. 60.6%, respectively; p = 0.004). There was no statistical difference in pregnancy rates per cycle between the treatment groups (8 vs. 11.7%, respectively; p = 0.33) leading to similar cumulative pregnancy rates (36.6 vs. 35.4%, respectively; p = 0.45). No difference was observed among the abortion rates (10 vs. 10%, respectively; p > 0.05) between the groups.

DISCUSSION

Although metformin and CC are two effective first-line approaches for improving pregnancy rates in anovulatory PCOS women, CC is associated with higher rates of ovulation.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Baran S
Department of Obstetrics and Gynecology, Haseki Education and Research Hospital, Istanbul, Turkey.
Api M
No affiliation info available
Goksedef BP
No affiliation info available
Cetin A
No affiliation info available

MeSH

AdultAnovulationClomipheneFemaleFertility Agents, FemaleHumansHypoglycemic AgentsInfertility, FemaleMetforminOvulationOvulation InductionPolycystic Ovary SyndromePregnancyPregnancy RateProspective StudiesTreatment OutcomeYoung Adult

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

20473763

Clinical Trial Links

Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin Resistant

Citation

Baran, Safak, et al. "Comparison of Metformin and Clomiphene Citrate Therapy for Induction of Ovulation in the Polycystic Ovary Syndrome." Archives of Gynecology and Obstetrics, vol. 282, no. 4, 2010, pp. 439-43.
Baran S, Api M, Goksedef BP, et al. Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome. Arch Gynecol Obstet. 2010;282(4):439-43.
Baran, S., Api, M., Goksedef, B. P., & Cetin, A. (2010). Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome. Archives of Gynecology and Obstetrics, 282(4), 439-43. https://doi.org/10.1007/s00404-010-1497-y
Baran S, et al. Comparison of Metformin and Clomiphene Citrate Therapy for Induction of Ovulation in the Polycystic Ovary Syndrome. Arch Gynecol Obstet. 2010;282(4):439-43. PubMed PMID: 20473763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of metformin and clomiphene citrate therapy for induction of ovulation in the polycystic ovary syndrome. AU - Baran,Safak, AU - Api,Murat, AU - Goksedef,Behiye Pinar Cilesiz, AU - Cetin,Ahmet, Y1 - 2010/05/16/ PY - 2010/02/25/received PY - 2010/04/22/accepted PY - 2010/5/18/entrez PY - 2010/5/18/pubmed PY - 2011/1/5/medline SP - 439 EP - 43 JF - Archives of gynecology and obstetrics JO - Arch Gynecol Obstet VL - 282 IS - 4 N2 - OBJECTIVE: To compare the efficacy of metformin and clomiphene citrate (CC) therapies for ovulation induction in anovulatory infertile women with polycystic ovary syndrome (PCOS). METHODS: A total of 69 consecutive infertile, anovulatory women with PCOS were enrolled in this prospective, non-randomized trial. The women were prescribed either 1,700 mg/day metformin or CC with a starting dose of 50 mg/day up to 150 mg/day for a period of six consecutive cycles. RESULTS: Metformin and CC groups were followed for a total of 136 and 94 cycles, respectively. Metformin group had lower rates of ovulation when compared with CC group (32.3 vs. 60.6%, respectively; p = 0.004). There was no statistical difference in pregnancy rates per cycle between the treatment groups (8 vs. 11.7%, respectively; p = 0.33) leading to similar cumulative pregnancy rates (36.6 vs. 35.4%, respectively; p = 0.45). No difference was observed among the abortion rates (10 vs. 10%, respectively; p > 0.05) between the groups. DISCUSSION: Although metformin and CC are two effective first-line approaches for improving pregnancy rates in anovulatory PCOS women, CC is associated with higher rates of ovulation. SN - 1432-0711 UR - https://www.unboundmedicine.com/medline/citation/20473763/Comparison_of_metformin_and_clomiphene_citrate_therapy_for_induction_of_ovulation_in_the_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -