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Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents.
J Nat Prod. 2010 Jun 25; 73(6):1180-3.JN

Abstract

Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), O-methylmoschatoline (5), lysicamine (6), liriodenine (7), 10-methoxyliriodenine (8), nornuciferine (9), anonaine (10), xylopine (11), coreximine (12), and isocoreximine (13). The major compounds, 2, 6, 12, and 13, showed significant antioxidant capacity in the ORAC(FL) assay. Compounds 5, 6, and 7 were active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1).

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Publisher Full Text (DOI)

Authors+Show Affiliations

Costa EV
Departamento de Quimica, Universidade Federal de Sergipe, Avenida Marechal Rondon, s/n, Rosa Elze, 49100-000, Sao Cristovao, SE, Brazil. emmanoelvilaca@yahoo.com.br
Pinheiro ML
No affiliation info available
Barison A
No affiliation info available
Campos FR
No affiliation info available
Salvador MJ
No affiliation info available
Maia BH
No affiliation info available
Cabral EC
No affiliation info available
Eberlin MN
No affiliation info available

MeSH

AlkaloidsAnti-Bacterial AgentsAntifungal AgentsAntioxidantsAporphinesBrazilCandidaEscherichia coliGuatteriaMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant BarkPlants, MedicinalPseudomonas aeruginosaStaphylococcus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20476748

Citation

Costa, Emmanoel Vilaça, et al. "Alkaloids From the Bark of Guatteria Hispida and Their Evaluation as Antioxidant and Antimicrobial Agents." Journal of Natural Products, vol. 73, no. 6, 2010, pp. 1180-3.
Costa EV, Pinheiro ML, Barison A, et al. Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents. J Nat Prod. 2010;73(6):1180-3.
Costa, E. V., Pinheiro, M. L., Barison, A., Campos, F. R., Salvador, M. J., Maia, B. H., Cabral, E. C., & Eberlin, M. N. (2010). Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents. Journal of Natural Products, 73(6), 1180-3. https://doi.org/10.1021/np100013r
Costa EV, et al. Alkaloids From the Bark of Guatteria Hispida and Their Evaluation as Antioxidant and Antimicrobial Agents. J Nat Prod. 2010 Jun 25;73(6):1180-3. PubMed PMID: 20476748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alkaloids from the bark of Guatteria hispida and their evaluation as antioxidant and antimicrobial agents. AU - Costa,Emmanoel Vilaça, AU - Pinheiro,Maria Lúcia B, AU - Barison,Andersson, AU - Campos,Francinete R, AU - Salvador,Marcos J, AU - Maia,Beatriz Helena L N S, AU - Cabral,Elaine C, AU - Eberlin,Marcos N, PY - 2010/5/19/entrez PY - 2010/5/19/pubmed PY - 2010/7/31/medline SP - 1180 EP - 3 JF - Journal of natural products JO - J Nat Prod VL - 73 IS - 6 N2 - Phytochemical investigation of the bark of Guatteria hispida afforded three new alkaloids, 9-methoxy-O-methylmoschatoline (1), 9-methoxyisomoschatoline (2), and isocerasonine (3), along with 10 known alkaloids, 8-oxopseudopalmatine (4), O-methylmoschatoline (5), lysicamine (6), liriodenine (7), 10-methoxyliriodenine (8), nornuciferine (9), anonaine (10), xylopine (11), coreximine (12), and isocoreximine (13). The major compounds, 2, 6, 12, and 13, showed significant antioxidant capacity in the ORAC(FL) assay. Compounds 5, 6, and 7 were active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/20476748/Alkaloids_from_the_bark_of_Guatteria_hispida_and_their_evaluation_as_antioxidant_and_antimicrobial_agents_ L2 - https://doi.org/10.1021/np100013r DB - PRIME DP - Unbound Medicine ER -