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Hashimoto's thyroiditis: TGAb, TPOAb, TRAb and recovery from hypothyroidism.
Expert Rev Clin Immunol 2008; 4(2):221-37ER

Abstract

Hashimoto described four patients with goiter. The histology of the goiter was characterized by diffuse lymphocytic infiltration, fibrosis and epithelial cell destruction. Thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) have been used to diagnose Hashimoto's thyroiditis. Patients with positive TGAb and/or TPOAb have been assumed to have Hashimoto's thyroiditis. Approximately 10% of those with positive TGAb and/or TPOAb have hypothyroidism. There are two types of autoimmune thyroiditis: goitrous Hashimoto's thyroiditis and atrophic thyroiditis. The latter patients have blocking antibody (thyroid-stimulating hormone [TSH]-stimulation blocking antibody [TSBAb]). TSBAb is a TSH-receptor antibody (TRAb). TSBAb causes thyroid atrophy and hypothyroidism. TGAb and/or TPOAb do not necessarily cause hypothyroidism. Hypothyroid patients with Hashimoto's thyroiditis usually receive life-long l-thyroxine therapy. However, spontaneous recovery from hypothyroidism has been reported. Patients who had Hashimoto's hypothyroidism and then Graves' hyperthyroidism (and vice versa), have also been reported. Hashimoto's hypothyroidism and Graves' hyperthyroidism could be the opposite spectrums of one disease.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, University of the Ryukyus, Uehara 207, Nishihara, Okinawa 903-0215, Japan. takasun@med.u-ryukyu.ac.jpNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20477052

Citation

Takasu, Nobuyuki, and Jaeduk Yoshimura Noh. "Hashimoto's Thyroiditis: TGAb, TPOAb, TRAb and Recovery From Hypothyroidism." Expert Review of Clinical Immunology, vol. 4, no. 2, 2008, pp. 221-37.
Takasu N, Yoshimura Noh J. Hashimoto's thyroiditis: TGAb, TPOAb, TRAb and recovery from hypothyroidism. Expert Rev Clin Immunol. 2008;4(2):221-37.
Takasu, N., & Yoshimura Noh, J. (2008). Hashimoto's thyroiditis: TGAb, TPOAb, TRAb and recovery from hypothyroidism. Expert Review of Clinical Immunology, 4(2), pp. 221-37. doi:10.1586/1744666X.4.2.221.
Takasu N, Yoshimura Noh J. Hashimoto's Thyroiditis: TGAb, TPOAb, TRAb and Recovery From Hypothyroidism. Expert Rev Clin Immunol. 2008;4(2):221-37. PubMed PMID: 20477052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hashimoto's thyroiditis: TGAb, TPOAb, TRAb and recovery from hypothyroidism. AU - Takasu,Nobuyuki, AU - Yoshimura Noh,Jaeduk, PY - 2010/5/19/entrez PY - 2008/3/1/pubmed PY - 2008/3/1/medline SP - 221 EP - 37 JF - Expert review of clinical immunology JO - Expert Rev Clin Immunol VL - 4 IS - 2 N2 - Hashimoto described four patients with goiter. The histology of the goiter was characterized by diffuse lymphocytic infiltration, fibrosis and epithelial cell destruction. Thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) have been used to diagnose Hashimoto's thyroiditis. Patients with positive TGAb and/or TPOAb have been assumed to have Hashimoto's thyroiditis. Approximately 10% of those with positive TGAb and/or TPOAb have hypothyroidism. There are two types of autoimmune thyroiditis: goitrous Hashimoto's thyroiditis and atrophic thyroiditis. The latter patients have blocking antibody (thyroid-stimulating hormone [TSH]-stimulation blocking antibody [TSBAb]). TSBAb is a TSH-receptor antibody (TRAb). TSBAb causes thyroid atrophy and hypothyroidism. TGAb and/or TPOAb do not necessarily cause hypothyroidism. Hypothyroid patients with Hashimoto's thyroiditis usually receive life-long l-thyroxine therapy. However, spontaneous recovery from hypothyroidism has been reported. Patients who had Hashimoto's hypothyroidism and then Graves' hyperthyroidism (and vice versa), have also been reported. Hashimoto's hypothyroidism and Graves' hyperthyroidism could be the opposite spectrums of one disease. SN - 1744-8409 UR - https://www.unboundmedicine.com/medline/citation/20477052/Hashimoto's_thyroiditis:_TGAb_TPOAb_TRAb_and_recovery_from_hypothyroidism_ L2 - http://www.tandfonline.com/doi/full/10.1586/1744666X.4.2.221 DB - PRIME DP - Unbound Medicine ER -