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Nasal vaccination with P6 outer membrane protein and alpha-galactosylceramide induces nontypeable Haemophilus influenzae-specific protective immunity associated with NKT cell activation and dendritic cell expansion in nasopharynx.
Vaccine. 2010 Jul 12; 28(31):5068-74.V

Abstract

The efficacy of alpha-galactosylceramide (alpha-GalCer) as a mucosal adjuvant was examined. Mice were immunized intranasally with nontypeable Haemophilus influenzae (NTHi) P6 protein and alpha-GalCer. P6-specific antibody responses in the form of P6-specific IgA in nasal washes and serum IgG titers were significantly elevated. Splenic CD4(+) T cells expressed P6-specific Th1 and Th2 cytokine mRNA. In addition, NTHi was quantified in nasal washes following NTHi challenges, and the clearance of NTHi from the nasopharynx was also enhanced. These results indicate that alpha-GalCer might be an effective mucosal adjuvant.

Authors+Show Affiliations

Department of Otolaryngology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hazama-machi, Yufu, Oita 879-5593, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20478344

Citation

Noda, Kenji, et al. "Nasal Vaccination With P6 Outer Membrane Protein and Alpha-galactosylceramide Induces Nontypeable Haemophilus Influenzae-specific Protective Immunity Associated With NKT Cell Activation and Dendritic Cell Expansion in Nasopharynx." Vaccine, vol. 28, no. 31, 2010, pp. 5068-74.
Noda K, Kodama S, Umemoto S, et al. Nasal vaccination with P6 outer membrane protein and alpha-galactosylceramide induces nontypeable Haemophilus influenzae-specific protective immunity associated with NKT cell activation and dendritic cell expansion in nasopharynx. Vaccine. 2010;28(31):5068-74.
Noda, K., Kodama, S., Umemoto, S., Abe, N., Hirano, T., & Suzuki, M. (2010). Nasal vaccination with P6 outer membrane protein and alpha-galactosylceramide induces nontypeable Haemophilus influenzae-specific protective immunity associated with NKT cell activation and dendritic cell expansion in nasopharynx. Vaccine, 28(31), 5068-74. https://doi.org/10.1016/j.vaccine.2010.05.005
Noda K, et al. Nasal Vaccination With P6 Outer Membrane Protein and Alpha-galactosylceramide Induces Nontypeable Haemophilus Influenzae-specific Protective Immunity Associated With NKT Cell Activation and Dendritic Cell Expansion in Nasopharynx. Vaccine. 2010 Jul 12;28(31):5068-74. PubMed PMID: 20478344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasal vaccination with P6 outer membrane protein and alpha-galactosylceramide induces nontypeable Haemophilus influenzae-specific protective immunity associated with NKT cell activation and dendritic cell expansion in nasopharynx. AU - Noda,Kenji, AU - Kodama,Satoru, AU - Umemoto,Shingo, AU - Abe,Nobuyuki, AU - Hirano,Takashi, AU - Suzuki,Masashi, Y1 - 2010/05/15/ PY - 2010/02/06/received PY - 2010/04/29/revised PY - 2010/05/03/accepted PY - 2010/5/19/entrez PY - 2010/5/19/pubmed PY - 2010/9/24/medline SP - 5068 EP - 74 JF - Vaccine JO - Vaccine VL - 28 IS - 31 N2 - The efficacy of alpha-galactosylceramide (alpha-GalCer) as a mucosal adjuvant was examined. Mice were immunized intranasally with nontypeable Haemophilus influenzae (NTHi) P6 protein and alpha-GalCer. P6-specific antibody responses in the form of P6-specific IgA in nasal washes and serum IgG titers were significantly elevated. Splenic CD4(+) T cells expressed P6-specific Th1 and Th2 cytokine mRNA. In addition, NTHi was quantified in nasal washes following NTHi challenges, and the clearance of NTHi from the nasopharynx was also enhanced. These results indicate that alpha-GalCer might be an effective mucosal adjuvant. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/20478344/Nasal_vaccination_with_P6_outer_membrane_protein_and_alpha_galactosylceramide_induces_nontypeable_Haemophilus_influenzae_specific_protective_immunity_associated_with_NKT_cell_activation_and_dendritic_cell_expansion_in_nasopharynx_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(10)00667-5 DB - PRIME DP - Unbound Medicine ER -