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Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway.
Food Chem Toxicol 2010 Aug-Sep; 48(8-9):2148-53FC

Abstract

Inflammation is part of the host defense mechanism against harmful matters and injury; however, aberrant inflammation is associated to the development of chronic disease such as cancer. Raspberry ketone is a natural phenolic compound. It is used in perfumery, in cosmetics, and as a food additive to impart a fruity odor. In this study, we evaluated whether rheosmin, a phenolic compound isolated from pine needles regulates the expression of iNOS and COX-2 protein in LPS-stimulated RAW264.7 cells. Rheosmin dose-dependently inhibited NO and PGE(2) production and also blocked LPS-induced iNOS and COX-2 expression. Rheosmin potently inhibited the translocation of NF-kappaB p65 into the nucleus by IkappaB degradation following IkappaB-alpha phosphorylation. This result shows that rheosmin inhibits NF-kappaB activation. In conclusion, our results suggest that rheosmin inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway.

Authors+Show Affiliations

Bioresource Sciences, Andong National University, Andong 760749, Republic of Korea.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20478352

Citation

Jeong, Jin Boo, and Hyung Jin Jeong. "Rheosmin, a Naturally Occurring Phenolic Compound Inhibits LPS-induced iNOS and COX-2 Expression in RAW264.7 Cells By Blocking NF-kappaB Activation Pathway." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 48, no. 8-9, 2010, pp. 2148-53.
Jeong JB, Jeong HJ. Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway. Food Chem Toxicol. 2010;48(8-9):2148-53.
Jeong, J. B., & Jeong, H. J. (2010). Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 48(8-9), pp. 2148-53. doi:10.1016/j.fct.2010.05.020.
Jeong JB, Jeong HJ. Rheosmin, a Naturally Occurring Phenolic Compound Inhibits LPS-induced iNOS and COX-2 Expression in RAW264.7 Cells By Blocking NF-kappaB Activation Pathway. Food Chem Toxicol. 2010;48(8-9):2148-53. PubMed PMID: 20478352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rheosmin, a naturally occurring phenolic compound inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway. AU - Jeong,Jin Boo, AU - Jeong,Hyung Jin, Y1 - 2010/05/15/ PY - 2010/03/10/received PY - 2010/05/02/revised PY - 2010/05/07/accepted PY - 2010/5/19/entrez PY - 2010/5/19/pubmed PY - 2010/11/4/medline SP - 2148 EP - 53 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 48 IS - 8-9 N2 - Inflammation is part of the host defense mechanism against harmful matters and injury; however, aberrant inflammation is associated to the development of chronic disease such as cancer. Raspberry ketone is a natural phenolic compound. It is used in perfumery, in cosmetics, and as a food additive to impart a fruity odor. In this study, we evaluated whether rheosmin, a phenolic compound isolated from pine needles regulates the expression of iNOS and COX-2 protein in LPS-stimulated RAW264.7 cells. Rheosmin dose-dependently inhibited NO and PGE(2) production and also blocked LPS-induced iNOS and COX-2 expression. Rheosmin potently inhibited the translocation of NF-kappaB p65 into the nucleus by IkappaB degradation following IkappaB-alpha phosphorylation. This result shows that rheosmin inhibits NF-kappaB activation. In conclusion, our results suggest that rheosmin inhibits LPS-induced iNOS and COX-2 expression in RAW264.7 cells by blocking NF-kappaB activation pathway. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/20478352/Rheosmin_a_naturally_occurring_phenolic_compound_inhibits_LPS_induced_iNOS_and_COX_2_expression_in_RAW264_7_cells_by_blocking_NF_kappaB_activation_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(10)00296-6 DB - PRIME DP - Unbound Medicine ER -