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The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter.
Neurosci Lett. 2010 Jul 26; 479(2):87-91.NL

Abstract

Chemical stimulation of the lateral nucleus of the habenula (LHb), an area implicated in the regulation of serotonergic activity in raphe nuclei, affects the acquisition of inhibitory avoidance and escape expression of rats submitted to the elevated T-maze test of anxiety. Here, we investigated whether facilitation of 5-HT-mediated neurotransmission in the dorsal periaqueductal gray (dPAG) accounts for the behavioral consequences in the elevated T-maze induced by chemical stimulation of the LHb. The dPAG in the midbrain, which is innervated by 5-HT fibers originating from the dorsal raphe nucleus (DRN), has been consistently implicated in the genesis/regulation of anxiety- and fear-related defensive responses. The results showed that intra-dPAG injection of WAY-100635 or ketanserin, 5-HT(1A) and 5-HT(2A/2C) receptor antagonists, respectively, counteracted the anti-escape effect caused by bilateral intra-LHb injection of kainic acid (60pmol/0.2microl). Ketanserin, but not WAY-100635, blocked kainic acid's facilitatory effect on inhibitory avoidance acquisition. Overall, the results suggest that the pathway connecting the LHb to the DRN is involved in the control of 5-HT release in the dPAG, and facilitation of 5-HT-mediated neurotransmission in the latter area distinctively impacts upon the expression of anxiety- and fear-related defensive behaviors. While stimulation of 5-HT(1A) receptors selectively affects escape performance, 5-HT(2A/2C) receptors modulate both inhibitory avoidance and escape.

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Authors+Show Affiliations

Pobbe RL
Department of Pharmacology, School of Medicine, University of São Paulo, Av. Bandeirantes, 3900, CEP 14049-900 Ribeirão Preto, Brazil. rogerlhp@usp.br
Zangrossi H
No affiliation info available

MeSH

AnimalsAvoidance LearningHabenulaKainic AcidKetanserinMaleMaze LearningMotor ActivityNeuronsPeriaqueductal GrayPiperazinesPyridinesRatsRats, WistarReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2AReceptor, Serotonin, 5-HT2CSerotoninSerotonin 5-HT1 Receptor AntagonistsSerotonin 5-HT2 Receptor AntagonistsSynaptic Transmission

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20478359

Citation

Pobbe, Roger Luis Henschel, and Helio Zangrossi. "The Lateral Habenula Regulates Defensive Behaviors Through Changes in 5-HT-mediated Neurotransmission in the Dorsal Periaqueductal Gray Matter." Neuroscience Letters, vol. 479, no. 2, 2010, pp. 87-91.
Pobbe RL, Zangrossi H. The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter. Neurosci Lett. 2010;479(2):87-91.
Pobbe, R. L., & Zangrossi, H. (2010). The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter. Neuroscience Letters, 479(2), 87-91. https://doi.org/10.1016/j.neulet.2010.05.021
Pobbe RL, Zangrossi H. The Lateral Habenula Regulates Defensive Behaviors Through Changes in 5-HT-mediated Neurotransmission in the Dorsal Periaqueductal Gray Matter. Neurosci Lett. 2010 Jul 26;479(2):87-91. PubMed PMID: 20478359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The lateral habenula regulates defensive behaviors through changes in 5-HT-mediated neurotransmission in the dorsal periaqueductal gray matter. AU - Pobbe,Roger Luis Henschel, AU - Zangrossi,Helio,Jr Y1 - 2010/05/15/ PY - 2009/11/20/received PY - 2010/05/04/revised PY - 2010/05/09/accepted PY - 2010/5/19/entrez PY - 2010/5/19/pubmed PY - 2010/9/29/medline SP - 87 EP - 91 JF - Neuroscience letters JO - Neurosci Lett VL - 479 IS - 2 N2 - Chemical stimulation of the lateral nucleus of the habenula (LHb), an area implicated in the regulation of serotonergic activity in raphe nuclei, affects the acquisition of inhibitory avoidance and escape expression of rats submitted to the elevated T-maze test of anxiety. Here, we investigated whether facilitation of 5-HT-mediated neurotransmission in the dorsal periaqueductal gray (dPAG) accounts for the behavioral consequences in the elevated T-maze induced by chemical stimulation of the LHb. The dPAG in the midbrain, which is innervated by 5-HT fibers originating from the dorsal raphe nucleus (DRN), has been consistently implicated in the genesis/regulation of anxiety- and fear-related defensive responses. The results showed that intra-dPAG injection of WAY-100635 or ketanserin, 5-HT(1A) and 5-HT(2A/2C) receptor antagonists, respectively, counteracted the anti-escape effect caused by bilateral intra-LHb injection of kainic acid (60pmol/0.2microl). Ketanserin, but not WAY-100635, blocked kainic acid's facilitatory effect on inhibitory avoidance acquisition. Overall, the results suggest that the pathway connecting the LHb to the DRN is involved in the control of 5-HT release in the dPAG, and facilitation of 5-HT-mediated neurotransmission in the latter area distinctively impacts upon the expression of anxiety- and fear-related defensive behaviors. While stimulation of 5-HT(1A) receptors selectively affects escape performance, 5-HT(2A/2C) receptors modulate both inhibitory avoidance and escape. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/20478359/The_lateral_habenula_regulates_defensive_behaviors_through_changes_in_5_HT_mediated_neurotransmission_in_the_dorsal_periaqueductal_gray_matter_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(10)00596-3 DB - PRIME DP - Unbound Medicine ER -