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Modulation of steroid hormone receptor activity.
Prog Brain Res. 2010; 181:153-76.PB

Abstract

Classical steroid hormones (SHs) - estrogens, androgens, progestins, glucocorticoids and mineralocorticoids - play critical roles in the regulation of reproduction, metabolism and cancer. SHs act via their cognate steroid hormone receptors (SHRs) in multiple target tissues throughout the body, exerting their physiological effects through nuclear receptor (NR)-mediated gene transcription. Since SHRs are the mediators of steroid hormone signalling in cells, regulation of their expression and function is critical for appropriate physiological responses to SHs. Cells regulate SHRs by determining the cellular concentration of SHR proteins in the cell and by tightly regulating their activity through post-translational modifications and interactions with coactivator protein complexes. In this chapter we will examine each of these regulatory mechanisms and assess their functional impact on the activity of SHRs.

Authors+Show Affiliations

Department of Molecular and Cellular Biology, Baylor College of Medicine, Texas, United States of America.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20478437

Citation

Stanisić, Vladimir, et al. "Modulation of Steroid Hormone Receptor Activity." Progress in Brain Research, vol. 181, 2010, pp. 153-76.
Stanisić V, Lonard DM, O'Malley BW. Modulation of steroid hormone receptor activity. Prog Brain Res. 2010;181:153-76.
Stanisić, V., Lonard, D. M., & O'Malley, B. W. (2010). Modulation of steroid hormone receptor activity. Progress in Brain Research, 181, 153-76. https://doi.org/10.1016/S0079-6123(08)81009-6
Stanisić V, Lonard DM, O'Malley BW. Modulation of Steroid Hormone Receptor Activity. Prog Brain Res. 2010;181:153-76. PubMed PMID: 20478437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of steroid hormone receptor activity. AU - Stanisić,Vladimir, AU - Lonard,David M, AU - O'Malley,Bert W, PY - 2010/5/19/entrez PY - 2010/5/19/pubmed PY - 2010/8/13/medline SP - 153 EP - 76 JF - Progress in brain research JO - Prog Brain Res VL - 181 N2 - Classical steroid hormones (SHs) - estrogens, androgens, progestins, glucocorticoids and mineralocorticoids - play critical roles in the regulation of reproduction, metabolism and cancer. SHs act via their cognate steroid hormone receptors (SHRs) in multiple target tissues throughout the body, exerting their physiological effects through nuclear receptor (NR)-mediated gene transcription. Since SHRs are the mediators of steroid hormone signalling in cells, regulation of their expression and function is critical for appropriate physiological responses to SHs. Cells regulate SHRs by determining the cellular concentration of SHR proteins in the cell and by tightly regulating their activity through post-translational modifications and interactions with coactivator protein complexes. In this chapter we will examine each of these regulatory mechanisms and assess their functional impact on the activity of SHRs. SN - 1875-7855 UR - https://www.unboundmedicine.com/medline/citation/20478437/Modulation_of_steroid_hormone_receptor_activity_ DB - PRIME DP - Unbound Medicine ER -