Tags

Type your tag names separated by a space and hit enter

A new computerized impedance plethysmograph: accuracy in the detection of proximal deep-vein thrombosis in symptomatic outpatients.
Thromb Haemost. 1991 Mar 04; 65(3):229-32.TH

Abstract

Because of the lack of specificity of the clinical diagnosis it is appropriate in patients with clinically suspected deep-vein thrombosis to apply an objective test before starting anticoagulant treatment. Impedance plethysmography is a highly accurate technique for the detection of proximal-vein thrombosis with a reported sensitivity and specificity of 93 and 97%, respectively. In all previous reported evaluations of impedance plethysmography an apparatus which was developed in 1971 was used. A new computerized impedance plethysmography, using a novel device to measure impedance, was blindly compared against venography in 443 consecutive outpatients with clinically suspected deep-vein thrombosis. In the first phase of the study the computerized impedance plethysmography test results of 242 symptomatic patients were used to develop a discriminant line. Subsequently, this discriminant line was validated in the second phase of the study in another 201 symptomatic patients. The combined sensitivity and specificity of these two phases for proximal-vein thrombosis was 91% [95% confidence interval (CI), 86 to 94%] and 94% and (95% CI, 90 to 96%), respectively, which compares favourably with impedance plethysmography. It is concluded that computerized impedance plethysmography is a simple, portable, non-invasive technique with a high accuracy for the detection of proximal vein thrombosis. However, before computerized impedance plethysmography can be used as the only test in the diagnosis of deep-vein thrombosis, the safety of withholding anticoagulant treatment to patients with repeated normal computerized test results should be assessed during long-term follow-up studies.

Authors+Show Affiliations

Second Institute of Internal Medicine, University Hospital of Padua, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2048046

Citation

Prandoni, P, et al. "A New Computerized Impedance Plethysmograph: Accuracy in the Detection of Proximal Deep-vein Thrombosis in Symptomatic Outpatients." Thrombosis and Haemostasis, vol. 65, no. 3, 1991, pp. 229-32.
Prandoni P, Lensing AW, Huisman MV, et al. A new computerized impedance plethysmograph: accuracy in the detection of proximal deep-vein thrombosis in symptomatic outpatients. Thromb Haemost. 1991;65(3):229-32.
Prandoni, P., Lensing, A. W., Huisman, M. V., Jonker, J. J., Vigo, M., Borm, J. J., Büller, H. R., Sing, A. K., Carta, M., & ten Cate, J. W. (1991). A new computerized impedance plethysmograph: accuracy in the detection of proximal deep-vein thrombosis in symptomatic outpatients. Thrombosis and Haemostasis, 65(3), 229-32.
Prandoni P, et al. A New Computerized Impedance Plethysmograph: Accuracy in the Detection of Proximal Deep-vein Thrombosis in Symptomatic Outpatients. Thromb Haemost. 1991 Mar 4;65(3):229-32. PubMed PMID: 2048046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new computerized impedance plethysmograph: accuracy in the detection of proximal deep-vein thrombosis in symptomatic outpatients. AU - Prandoni,P, AU - Lensing,A W, AU - Huisman,M V, AU - Jonker,J J, AU - Vigo,M, AU - Borm,J J, AU - Büller,H R, AU - Sing,A K, AU - Carta,M, AU - ten Cate,J W, PY - 1991/3/4/pubmed PY - 1991/3/4/medline PY - 1991/3/4/entrez SP - 229 EP - 32 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 65 IS - 3 N2 - Because of the lack of specificity of the clinical diagnosis it is appropriate in patients with clinically suspected deep-vein thrombosis to apply an objective test before starting anticoagulant treatment. Impedance plethysmography is a highly accurate technique for the detection of proximal-vein thrombosis with a reported sensitivity and specificity of 93 and 97%, respectively. In all previous reported evaluations of impedance plethysmography an apparatus which was developed in 1971 was used. A new computerized impedance plethysmography, using a novel device to measure impedance, was blindly compared against venography in 443 consecutive outpatients with clinically suspected deep-vein thrombosis. In the first phase of the study the computerized impedance plethysmography test results of 242 symptomatic patients were used to develop a discriminant line. Subsequently, this discriminant line was validated in the second phase of the study in another 201 symptomatic patients. The combined sensitivity and specificity of these two phases for proximal-vein thrombosis was 91% [95% confidence interval (CI), 86 to 94%] and 94% and (95% CI, 90 to 96%), respectively, which compares favourably with impedance plethysmography. It is concluded that computerized impedance plethysmography is a simple, portable, non-invasive technique with a high accuracy for the detection of proximal vein thrombosis. However, before computerized impedance plethysmography can be used as the only test in the diagnosis of deep-vein thrombosis, the safety of withholding anticoagulant treatment to patients with repeated normal computerized test results should be assessed during long-term follow-up studies. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/2048046/A_new_computerized_impedance_plethysmograph:_accuracy_in_the_detection_of_proximal_deep_vein_thrombosis_in_symptomatic_outpatients_ L2 - https://www.diseaseinfosearch.org/result/7087 DB - PRIME DP - Unbound Medicine ER -