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Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion.
J Inflamm (Lond) 2010; 7:22JI

Abstract

OBJECTIVE

To determine the extent of linezolid and ertapenem penetration into the empyemic fluid using a rabbit model of empyema.

METHODS

An empyema was created via the intrapleural injection of Escherichia coli bacteria (ATCC 35218) into the pleural space of New Zealand white rabbits. After an empyema was verified by thoracocentesis, 24 hours post inoculation, linezolid (10 mg/kg) and ertapenem (60 mg/kg) were administered intravenously into 10 and 8 infected empyemic rabbits, respectively. Antibiotic levels were determined in samples of pleural fluid and blood serum, collected serially at 1, 2, 4, 6 and 8 hours, after administration each of the two antibiotics.

RESULTS

Linezolid as well as ertapenem penetrate well into the empyemic pleural fluid, exhibiting a slower onset and decline compared to the corresponding blood serum levels. Equilibration between blood serum and pleural fluid compartments seems to occur at 1.5 hours for both linezolid and ertapenem, with peak pleural fluid levels (Cmaxpf of 2.02 +/- 0.73 <<mu>>g/ml and Cmaxpf of 3.74 +/- 1.39 <<mu>>g/ml, correspondingly) occurring 2 hours post antibiotics administration and decreasing very slowly thereafter. The serum concentrations for both antibiotics were significantly lower from the corresponding pleural fluid ones during the 8 hours collecting data, with the exception of samples collected at the 1st hour (Cmaxserum of 2.1 +/- 1.2 <<mu>>g/ml for linezolid and Cmaxserum of 6.26 +/- 2.98 <<mu>>g/ml for ertapenem).

CONCLUSION

Pleural fluid levels of both antibiotics are inhibitory for common specified pathogens causing empyema.

Authors+Show Affiliations

Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece. bouros@med.duth.gr.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20482752

Citation

Saroglou, Maria, et al. "Pharmacokinetics of Linezolid and Ertapenem in Experimental Parapneumonic Pleural Effusion." Journal of Inflammation (London, England), vol. 7, 2010, p. 22.
Saroglou M, Tryfon S, Ismailos G, et al. Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion. J Inflamm (Lond). 2010;7:22.
Saroglou, M., Tryfon, S., Ismailos, G., Liapakis, I., Tzatzarakis, M., Tsatsakis, A., ... Bouros, D. (2010). Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion. Journal of Inflammation (London, England), 7, p. 22. doi:10.1186/1476-9255-7-22.
Saroglou M, et al. Pharmacokinetics of Linezolid and Ertapenem in Experimental Parapneumonic Pleural Effusion. J Inflamm (Lond). 2010 May 18;7:22. PubMed PMID: 20482752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion. AU - Saroglou,Maria, AU - Tryfon,Stavros, AU - Ismailos,Georgios, AU - Liapakis,Ioannis, AU - Tzatzarakis,Manolis, AU - Tsatsakis,Aristidis, AU - Papalois,Apostolos, AU - Bouros,Demosthenes, Y1 - 2010/05/18/ PY - 2009/04/08/received PY - 2010/05/18/accepted PY - 2010/5/21/entrez PY - 2010/5/21/pubmed PY - 2010/5/21/medline SP - 22 EP - 22 JF - Journal of inflammation (London, England) JO - J Inflamm (Lond) VL - 7 N2 - OBJECTIVE: To determine the extent of linezolid and ertapenem penetration into the empyemic fluid using a rabbit model of empyema. METHODS: An empyema was created via the intrapleural injection of Escherichia coli bacteria (ATCC 35218) into the pleural space of New Zealand white rabbits. After an empyema was verified by thoracocentesis, 24 hours post inoculation, linezolid (10 mg/kg) and ertapenem (60 mg/kg) were administered intravenously into 10 and 8 infected empyemic rabbits, respectively. Antibiotic levels were determined in samples of pleural fluid and blood serum, collected serially at 1, 2, 4, 6 and 8 hours, after administration each of the two antibiotics. RESULTS: Linezolid as well as ertapenem penetrate well into the empyemic pleural fluid, exhibiting a slower onset and decline compared to the corresponding blood serum levels. Equilibration between blood serum and pleural fluid compartments seems to occur at 1.5 hours for both linezolid and ertapenem, with peak pleural fluid levels (Cmaxpf of 2.02 +/- 0.73 <<mu>>g/ml and Cmaxpf of 3.74 +/- 1.39 <<mu>>g/ml, correspondingly) occurring 2 hours post antibiotics administration and decreasing very slowly thereafter. The serum concentrations for both antibiotics were significantly lower from the corresponding pleural fluid ones during the 8 hours collecting data, with the exception of samples collected at the 1st hour (Cmaxserum of 2.1 +/- 1.2 <<mu>>g/ml for linezolid and Cmaxserum of 6.26 +/- 2.98 <<mu>>g/ml for ertapenem). CONCLUSION: Pleural fluid levels of both antibiotics are inhibitory for common specified pathogens causing empyema. SN - 1476-9255 UR - https://www.unboundmedicine.com/medline/citation/20482752/Pharmacokinetics_of_Linezolid_and_Ertapenem_in_experimental_parapneumonic_pleural_effusion_ L2 - https://journal-inflammation.biomedcentral.com/articles/10.1186/1476-9255-7-22 DB - PRIME DP - Unbound Medicine ER -