Tags

Type your tag names separated by a space and hit enter

Synthesis of poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide])-folate for drug delivery.
J Biomater Sci Polym Ed 2010; 21(6-7):759-70JB

Abstract

Poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide])-folate (PHEA-FA) was synthesized by linking FA to a poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]) (PHEA) backbone. The chemical structure of PHEA-FA was characterized by (1)H-NMR and FT-IR. The molecular weights of the polymers were determined by combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. Due to the incorporation of FA, PHEA-FA exhibited pH-sensitive aggregation behavior in aqueous media. As characterized by UV-Vis spectroscopy and fluorescence spectroscopy, PHEA-FA could self-assemble to form aggregates in acidic and neutral aqueous solutions, and became soluble in a basic solution. The potential application of PHEA-FA in drug delivery was explored. Drug-loaded PHEA-FA nanoparticles were fabricated and the in vitro drug release of the drug-loaded nanoparticles was investigated. Transmission electron microscopy (TEM) showed that the nanoparticles exhibited a spherical morphology with particle sizes <100 nm. The in vitro study showed PHEA-FA exhibited enhanced cell uptake on the folate-receptor-positive cells because of the folate-mediated targeting.

Authors+Show Affiliations

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20482983

Citation

Zou, Tao, et al. "Synthesis of poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide])-folate for Drug Delivery." Journal of Biomaterials Science. Polymer Edition, vol. 21, no. 6-7, 2010, pp. 759-70.
Zou T, Li SL, Cheng SX, et al. Synthesis of poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide])-folate for drug delivery. J Biomater Sci Polym Ed. 2010;21(6-7):759-70.
Zou, T., Li, S. L., Cheng, S. X., Zhang, X. Z., & Zhuo, R. X. (2010). Synthesis of poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide])-folate for drug delivery. Journal of Biomaterials Science. Polymer Edition, 21(6-7), pp. 759-70. doi:10.1163/156856209X441991.
Zou T, et al. Synthesis of poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide])-folate for Drug Delivery. J Biomater Sci Polym Ed. 2010;21(6-7):759-70. PubMed PMID: 20482983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide])-folate for drug delivery. AU - Zou,Tao, AU - Li,Song-Lin, AU - Cheng,Si-Xue, AU - Zhang,Xian-Zheng, AU - Zhuo,Ren-Xi, PY - 2010/5/21/entrez PY - 2010/5/21/pubmed PY - 2010/8/26/medline SP - 759 EP - 70 JF - Journal of biomaterials science. Polymer edition JO - J Biomater Sci Polym Ed VL - 21 IS - 6-7 N2 - Poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide])-folate (PHEA-FA) was synthesized by linking FA to a poly(alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]) (PHEA) backbone. The chemical structure of PHEA-FA was characterized by (1)H-NMR and FT-IR. The molecular weights of the polymers were determined by combined size-exclusion chromatography and multiangle laser light scattering (SEC-MALLS) analysis. Due to the incorporation of FA, PHEA-FA exhibited pH-sensitive aggregation behavior in aqueous media. As characterized by UV-Vis spectroscopy and fluorescence spectroscopy, PHEA-FA could self-assemble to form aggregates in acidic and neutral aqueous solutions, and became soluble in a basic solution. The potential application of PHEA-FA in drug delivery was explored. Drug-loaded PHEA-FA nanoparticles were fabricated and the in vitro drug release of the drug-loaded nanoparticles was investigated. Transmission electron microscopy (TEM) showed that the nanoparticles exhibited a spherical morphology with particle sizes <100 nm. The in vitro study showed PHEA-FA exhibited enhanced cell uptake on the folate-receptor-positive cells because of the folate-mediated targeting. SN - 1568-5624 UR - https://www.unboundmedicine.com/medline/citation/20482983/Synthesis_of_poly_alphabeta_[N__2_hydroxyethyl__L_aspartamide]__folate_for_drug_delivery_ L2 - http://www.tandfonline.com/doi/full/10.1163/156856209X441991 DB - PRIME DP - Unbound Medicine ER -