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Resting-state EEG gamma activity in children with attention-deficit/hyperactivity disorder.
Clin Neurophysiol 2010; 121(11):1871-7CN

Abstract

OBJECTIVE

Children with Attention-Deficit/Hyperactivity Disorder (AD/HD) have well-described abnormalities in the four traditional EEG bands. However, to date the gamma band has not been widely investigated. This study investigated resting-state EEG in children with AD/HD and matched controls, with a particular focus on gamma activity.

METHOD

Forty children with AD/HD, and 40 age- and sex-matched controls, participated. EEG was recorded from 19 sites during an eyes-closed resting condition and Fourier transformed to provide estimates for absolute and relative power in the delta, theta, alpha, beta and gamma bands.

RESULTS

Children with AD/HD had elevated levels of absolute delta and theta power, and decreased levels of absolute beta and gamma power, compared to controls. With relative power measures, children with AD/HD showed enhanced delta and theta activity, with reduced alpha, beta and gamma activity. Inattention scores on the Conners' Parent Rating Scale were negatively correlated with absolute gamma.

CONCLUSIONS

These patients demonstrate the typical EEG profile in the eyes-closed resting state, over the delta, theta, alpha and beta bands, associated with AD/HD. In addition, compared with controls, they demonstrate reduced absolute and relative gamma activity. These differences appear to contribute importantly to their dysfunctional stimulus processing, and impact their behavioural outcomes.

SIGNIFICANCE

This resting-state study extends the well-established fast-wave EEG deficits in children with AD/HD to the gamma band, and links that to increased inattention, which is of special importance in understanding their cognitive-processing problems.

Authors+Show Affiliations

Brain & Behaviour Research Institute and School of Psychology, University of Wollongong, Wollongong 2522, Australia. Robert_Barry@uow.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20483659

Citation

Barry, Robert J., et al. "Resting-state EEG Gamma Activity in Children With Attention-deficit/hyperactivity Disorder." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 121, no. 11, 2010, pp. 1871-7.
Barry RJ, Clarke AR, Hajos M, et al. Resting-state EEG gamma activity in children with attention-deficit/hyperactivity disorder. Clin Neurophysiol. 2010;121(11):1871-7.
Barry, R. J., Clarke, A. R., Hajos, M., McCarthy, R., Selikowitz, M., & Dupuy, F. E. (2010). Resting-state EEG gamma activity in children with attention-deficit/hyperactivity disorder. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 121(11), pp. 1871-7. doi:10.1016/j.clinph.2010.04.022.
Barry RJ, et al. Resting-state EEG Gamma Activity in Children With Attention-deficit/hyperactivity Disorder. Clin Neurophysiol. 2010;121(11):1871-7. PubMed PMID: 20483659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resting-state EEG gamma activity in children with attention-deficit/hyperactivity disorder. AU - Barry,Robert J, AU - Clarke,Adam R, AU - Hajos,Mihaly, AU - McCarthy,Rory, AU - Selikowitz,Mark, AU - Dupuy,Franca E, Y1 - 2010/05/18/ PY - 2009/02/10/received PY - 2010/04/20/revised PY - 2010/04/21/accepted PY - 2010/5/21/entrez PY - 2010/5/21/pubmed PY - 2010/10/15/medline SP - 1871 EP - 7 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 121 IS - 11 N2 - OBJECTIVE: Children with Attention-Deficit/Hyperactivity Disorder (AD/HD) have well-described abnormalities in the four traditional EEG bands. However, to date the gamma band has not been widely investigated. This study investigated resting-state EEG in children with AD/HD and matched controls, with a particular focus on gamma activity. METHOD: Forty children with AD/HD, and 40 age- and sex-matched controls, participated. EEG was recorded from 19 sites during an eyes-closed resting condition and Fourier transformed to provide estimates for absolute and relative power in the delta, theta, alpha, beta and gamma bands. RESULTS: Children with AD/HD had elevated levels of absolute delta and theta power, and decreased levels of absolute beta and gamma power, compared to controls. With relative power measures, children with AD/HD showed enhanced delta and theta activity, with reduced alpha, beta and gamma activity. Inattention scores on the Conners' Parent Rating Scale were negatively correlated with absolute gamma. CONCLUSIONS: These patients demonstrate the typical EEG profile in the eyes-closed resting state, over the delta, theta, alpha and beta bands, associated with AD/HD. In addition, compared with controls, they demonstrate reduced absolute and relative gamma activity. These differences appear to contribute importantly to their dysfunctional stimulus processing, and impact their behavioural outcomes. SIGNIFICANCE: This resting-state study extends the well-established fast-wave EEG deficits in children with AD/HD to the gamma band, and links that to increased inattention, which is of special importance in understanding their cognitive-processing problems. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/20483659/Resting_state_EEG_gamma_activity_in_children_with_attention_deficit/hyperactivity_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(10)00375-5 DB - PRIME DP - Unbound Medicine ER -