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Epstein-Barr virus-specific antibody response in cerebrospinal fluid and serum of patients with multiple sclerosis.
Mult Scler. 2010 Jul; 16(7):883-7.MS

Abstract

Cerebrospinal fluid and serum levels and intrathecal synthesis of anti-Epstein-Barr virus (EBV) IgG were measured by enzyme-linked immunosorbent assay in 80 relapsing-remitting multiple sclerosis patients grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity. Eighty patients with other inflammatory neurological disorders (OIND) and 80 patients with non-inflammatory neurological disorders (NIND) served as neurological controls. Cerebrospinal fluid concentrations were higher in OIND than in multiple sclerosis (p < 0.0001) and NIND (p < 0.01) for anti-viral-capsid-antigen (anti-VCA) IgG, in multiple sclerosis than in NIND (p < 0.01) and in OIND than in NIND (p < 0.05) for anti-EBV nuclear antigen-1 (EBNA-1) IgG. Serum levels were more elevated in OIND than in multiple sclerosis (p < 0.05) and in MRI inactive than in MRI active multiple sclerosis (p < 0.0001) for anti-VCA IgG, and in multiple sclerosis than in OIND and NIND (p < 0.01) for anti-EBNA-1 IgG. Serum titres of anti-VCA and anti-EBNA-1 IgG were also positively (p < 0.05) and inversely (p < 0.001) correlated, respectively, with the Expanded Disability Status Scale. An intrathecal IgG production of anti-VCA and anti-EBNA-1 IgG, as indicated by Antibody Index, was present only in a limited number of multiple sclerosis patients and controls (range from 1.3 to 6.3%). These findings do not support a direct pathogenetic role of EBV-targeted humoral immune response in multiple sclerosis.

Authors+Show Affiliations

Section of Neurology, Department of Medical and Surgical Sciences of Communication and Behaviour, University of Ferrara, Ferrara, Italy. massimiliano.castellazzi@unife.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20483883

Citation

Castellazzi, Massimiliano, et al. "Epstein-Barr Virus-specific Antibody Response in Cerebrospinal Fluid and Serum of Patients With Multiple Sclerosis." Multiple Sclerosis (Houndmills, Basingstoke, England), vol. 16, no. 7, 2010, pp. 883-7.
Castellazzi M, Tamborino C, Cani A, et al. Epstein-Barr virus-specific antibody response in cerebrospinal fluid and serum of patients with multiple sclerosis. Mult Scler. 2010;16(7):883-7.
Castellazzi, M., Tamborino, C., Cani, A., Negri, E., Baldi, E., Seraceni, S., Tola, M. R., Granieri, E., Contini, C., & Fainardi, E. (2010). Epstein-Barr virus-specific antibody response in cerebrospinal fluid and serum of patients with multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England), 16(7), 883-7. https://doi.org/10.1177/1352458510368051
Castellazzi M, et al. Epstein-Barr Virus-specific Antibody Response in Cerebrospinal Fluid and Serum of Patients With Multiple Sclerosis. Mult Scler. 2010;16(7):883-7. PubMed PMID: 20483883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epstein-Barr virus-specific antibody response in cerebrospinal fluid and serum of patients with multiple sclerosis. AU - Castellazzi,Massimiliano, AU - Tamborino,Carmine, AU - Cani,Alice, AU - Negri,Elena, AU - Baldi,Eleonora, AU - Seraceni,Silva, AU - Tola,Maria Rosaria, AU - Granieri,Enrico, AU - Contini,Carlo, AU - Fainardi,Enrico, Y1 - 2010/05/18/ PY - 2010/5/21/entrez PY - 2010/5/21/pubmed PY - 2010/10/27/medline SP - 883 EP - 7 JF - Multiple sclerosis (Houndmills, Basingstoke, England) JO - Mult Scler VL - 16 IS - 7 N2 - Cerebrospinal fluid and serum levels and intrathecal synthesis of anti-Epstein-Barr virus (EBV) IgG were measured by enzyme-linked immunosorbent assay in 80 relapsing-remitting multiple sclerosis patients grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity. Eighty patients with other inflammatory neurological disorders (OIND) and 80 patients with non-inflammatory neurological disorders (NIND) served as neurological controls. Cerebrospinal fluid concentrations were higher in OIND than in multiple sclerosis (p < 0.0001) and NIND (p < 0.01) for anti-viral-capsid-antigen (anti-VCA) IgG, in multiple sclerosis than in NIND (p < 0.01) and in OIND than in NIND (p < 0.05) for anti-EBV nuclear antigen-1 (EBNA-1) IgG. Serum levels were more elevated in OIND than in multiple sclerosis (p < 0.05) and in MRI inactive than in MRI active multiple sclerosis (p < 0.0001) for anti-VCA IgG, and in multiple sclerosis than in OIND and NIND (p < 0.01) for anti-EBNA-1 IgG. Serum titres of anti-VCA and anti-EBNA-1 IgG were also positively (p < 0.05) and inversely (p < 0.001) correlated, respectively, with the Expanded Disability Status Scale. An intrathecal IgG production of anti-VCA and anti-EBNA-1 IgG, as indicated by Antibody Index, was present only in a limited number of multiple sclerosis patients and controls (range from 1.3 to 6.3%). These findings do not support a direct pathogenetic role of EBV-targeted humoral immune response in multiple sclerosis. SN - 1477-0970 UR - https://www.unboundmedicine.com/medline/citation/20483883/Epstein_Barr_virus_specific_antibody_response_in_cerebrospinal_fluid_and_serum_of_patients_with_multiple_sclerosis_ L2 - https://journals.sagepub.com/doi/10.1177/1352458510368051?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -