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Early waning of maternal measles antibodies in era of measles elimination: longitudinal study.
BMJ. 2010 May 18; 340:c1626.BMJ

Abstract

OBJECTIVE

To investigate the duration of the presence of maternal antibodies to measles in infants.

DESIGN

Prospective study (May 2006 to November 2008).

SETTING

Five hospitals in the Province of Antwerp, Belgium.

PARTICIPANTS

Of 221 pregnant women recruited, 207 healthy woman-infant pairs were included-divided into a vaccinated group (n=87) and naturally immune group (n=120), according to vaccination documents and history.

MAIN OUTCOME MEASURE

Measles IgG antibodies measured by enzyme linked immunosorbent assay (ELISA) at seven time points (week 36 of pregnancy, birth (cord), and 1, 6, 9, and 12 months); decay of maternal antibody in infants modelled with linear mixed models.

RESULTS

Vaccinated women had significantly fewer IgG antibodies (geometric mean titre 779 (95% confidence interval 581 to 1045) mIU/ml) than did naturally immune women (2687 (2126 to 3373) mIU/ml) (P<0.001). Maternal values were highly correlated with neonatal values (r=0.93 at birth). Infants of vaccinated women had significantly lower antibody concentrations than did infants of naturally immune women (P<0.001 at all ages over the follow-up period). Presence of maternal antibodies endured for a median of 2.61 months-3.78 months for infants of naturally infected women and 0.97 months for infants of vaccinated women. At 6 months of age, more than 99% of infants of vaccinated women and 95% of infants of naturally immune women had lost maternal antibodies according to the model.

CONCLUSIONS

This study describes a very early susceptibility to measles in infants of both vaccinated women and women with naturally acquired immunity. This finding is important in view of recent outbreaks and is an argument for timeliness of the first dose of a measles vaccine and vaccination of travelling or migrating children under the age of 1 year.

Authors+Show Affiliations

Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, Faculty of Medicine, University of Antwerp, Universiteitsplein, 1, 2610 Wilrijk, Belgium. elke.leuridan@ua.ac.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20483946

Citation

Leuridan, E, et al. "Early Waning of Maternal Measles Antibodies in Era of Measles Elimination: Longitudinal Study." BMJ (Clinical Research Ed.), vol. 340, 2010, p. c1626.
Leuridan E, Hens N, Hutse V, et al. Early waning of maternal measles antibodies in era of measles elimination: longitudinal study. BMJ. 2010;340:c1626.
Leuridan, E., Hens, N., Hutse, V., Ieven, M., Aerts, M., & Van Damme, P. (2010). Early waning of maternal measles antibodies in era of measles elimination: longitudinal study. BMJ (Clinical Research Ed.), 340, c1626. https://doi.org/10.1136/bmj.c1626
Leuridan E, et al. Early Waning of Maternal Measles Antibodies in Era of Measles Elimination: Longitudinal Study. BMJ. 2010 May 18;340:c1626. PubMed PMID: 20483946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early waning of maternal measles antibodies in era of measles elimination: longitudinal study. AU - Leuridan,E, AU - Hens,N, AU - Hutse,V, AU - Ieven,M, AU - Aerts,M, AU - Van Damme,P, Y1 - 2010/05/18/ PY - 2010/5/21/entrez PY - 2010/5/21/pubmed PY - 2010/6/9/medline SP - c1626 EP - c1626 JF - BMJ (Clinical research ed.) JO - BMJ VL - 340 N2 - OBJECTIVE: To investigate the duration of the presence of maternal antibodies to measles in infants. DESIGN: Prospective study (May 2006 to November 2008). SETTING: Five hospitals in the Province of Antwerp, Belgium. PARTICIPANTS: Of 221 pregnant women recruited, 207 healthy woman-infant pairs were included-divided into a vaccinated group (n=87) and naturally immune group (n=120), according to vaccination documents and history. MAIN OUTCOME MEASURE: Measles IgG antibodies measured by enzyme linked immunosorbent assay (ELISA) at seven time points (week 36 of pregnancy, birth (cord), and 1, 6, 9, and 12 months); decay of maternal antibody in infants modelled with linear mixed models. RESULTS: Vaccinated women had significantly fewer IgG antibodies (geometric mean titre 779 (95% confidence interval 581 to 1045) mIU/ml) than did naturally immune women (2687 (2126 to 3373) mIU/ml) (P<0.001). Maternal values were highly correlated with neonatal values (r=0.93 at birth). Infants of vaccinated women had significantly lower antibody concentrations than did infants of naturally immune women (P<0.001 at all ages over the follow-up period). Presence of maternal antibodies endured for a median of 2.61 months-3.78 months for infants of naturally infected women and 0.97 months for infants of vaccinated women. At 6 months of age, more than 99% of infants of vaccinated women and 95% of infants of naturally immune women had lost maternal antibodies according to the model. CONCLUSIONS: This study describes a very early susceptibility to measles in infants of both vaccinated women and women with naturally acquired immunity. This finding is important in view of recent outbreaks and is an argument for timeliness of the first dose of a measles vaccine and vaccination of travelling or migrating children under the age of 1 year. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/20483946/Early_waning_of_maternal_measles_antibodies_in_era_of_measles_elimination:_longitudinal_study_ L2 - https://www.bmj.com/lookup/pmidlookup?view=long&amp;pmid=20483946 DB - PRIME DP - Unbound Medicine ER -