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Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study.
Am J Clin Nutr. 2010 Jul; 92(1):258-65.AJ

Abstract

BACKGROUND

The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies.

OBJECTIVE

We examined whether genetic variations in the FADS gene cluster region interact with dietary intakes of n-3 (omega-3) and n-6 (omega-6) PUFAs to affect plasma total, HDL-, and non-HDL-cholesterol concentrations.

DESIGN

Dietary intakes of n-3 and n-6 PUFAs, plasma concentrations of total and HDL cholesterol, and rs174546, rs482548, and rs174570 in the FADS gene cluster region were measured in 3575 subjects in the second survey of the Doetinchem Cohort Study.

RESULTS

Significant associations between rs174546 genotypes and total and non-HDL-cholesterol concentrations were observed in the group with a high intake of n-3 PUFAs (> or =0.51% of total energy; P = 0.006 and 0.047, respectively) but not in the low-intake group (P for interaction = 0.32 and 0.51, respectively). The C allele was associated with high total and non-HDL-cholesterol concentrations. Furthermore, the C allele was significantly associated with high HDL-cholesterol concentrations in the group with a high intake of n-6 PUFAs (> or =5.26% of total energy, P = 0.004) but not in the group with a low intake (P for interaction = 0.02).

CONCLUSION

Genetic variation in the FADS1 gene potentially interacts with dietary PUFA intakes to affect plasma cholesterol concentrations, which should be investigated further in other studies.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University Research Center, Wageningen, Netherlands. kevin.lu@wur.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20484448

Citation

Lu, Yingchang, et al. "Dietary N-3 and N-6 Polyunsaturated Fatty Acid Intake Interacts With FADS1 Genetic Variation to Affect Total and HDL-cholesterol Concentrations in the Doetinchem Cohort Study." The American Journal of Clinical Nutrition, vol. 92, no. 1, 2010, pp. 258-65.
Lu Y, Feskens EJ, Dollé ME, et al. Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study. Am J Clin Nutr. 2010;92(1):258-65.
Lu, Y., Feskens, E. J., Dollé, M. E., Imholz, S., Verschuren, W. M., Müller, M., & Boer, J. M. (2010). Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study. The American Journal of Clinical Nutrition, 92(1), 258-65. https://doi.org/10.3945/ajcn.2009.29130
Lu Y, et al. Dietary N-3 and N-6 Polyunsaturated Fatty Acid Intake Interacts With FADS1 Genetic Variation to Affect Total and HDL-cholesterol Concentrations in the Doetinchem Cohort Study. Am J Clin Nutr. 2010;92(1):258-65. PubMed PMID: 20484448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study. AU - Lu,Yingchang, AU - Feskens,Edith Jm, AU - Dollé,Martijn Et, AU - Imholz,Sandra, AU - Verschuren,Wm Monique, AU - Müller,Michael, AU - Boer,Jolanda Ma, Y1 - 2010/05/19/ PY - 2010/5/21/entrez PY - 2010/5/21/pubmed PY - 2010/7/8/medline SP - 258 EP - 65 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 1 N2 - BACKGROUND: The delta-5 and delta-6 desaturases, encoded by the FADS1 and FADS2 genes, are rate-limiting enzymes in polyunsaturated fatty acid (PUFA) biosynthesis. Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies. OBJECTIVE: We examined whether genetic variations in the FADS gene cluster region interact with dietary intakes of n-3 (omega-3) and n-6 (omega-6) PUFAs to affect plasma total, HDL-, and non-HDL-cholesterol concentrations. DESIGN: Dietary intakes of n-3 and n-6 PUFAs, plasma concentrations of total and HDL cholesterol, and rs174546, rs482548, and rs174570 in the FADS gene cluster region were measured in 3575 subjects in the second survey of the Doetinchem Cohort Study. RESULTS: Significant associations between rs174546 genotypes and total and non-HDL-cholesterol concentrations were observed in the group with a high intake of n-3 PUFAs (> or =0.51% of total energy; P = 0.006 and 0.047, respectively) but not in the low-intake group (P for interaction = 0.32 and 0.51, respectively). The C allele was associated with high total and non-HDL-cholesterol concentrations. Furthermore, the C allele was significantly associated with high HDL-cholesterol concentrations in the group with a high intake of n-6 PUFAs (> or =5.26% of total energy, P = 0.004) but not in the group with a low intake (P for interaction = 0.02). CONCLUSION: Genetic variation in the FADS1 gene potentially interacts with dietary PUFA intakes to affect plasma cholesterol concentrations, which should be investigated further in other studies. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20484448/Dietary_n_3_and_n_6_polyunsaturated_fatty_acid_intake_interacts_with_FADS1_genetic_variation_to_affect_total_and_HDL_cholesterol_concentrations_in_the_Doetinchem_Cohort_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.29130 DB - PRIME DP - Unbound Medicine ER -