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Depression, anxiety, and stress comorbidities in sickle cell anemia patients with vaso-occlusive crisis.
J Pediatr Hematol Oncol. 2010 Jul; 32(5):345-9.JP

Abstract

We investigated the association of sickle cell anemia (SCA) vaso-occlusive crisis (VOC) with depression, anxiety, and stress disorders among Bahraini patients and controls. This was a cross-sectional study that involved administering Depression Anxiety Stress Scales (DASS-21) consisting of structured depression, anxiety, and stress scales to SCA patients with (n=138) and without (n=105) VOC. Multinomial regression and correlation analysis were used in assessing the association of VOC with depression and/or anxiety and/or stress, after adjusting for other covariates. Significantly higher proportion of VOC patients was found among the severe-extremely severe anxiety (P<0.002) and stress (P=0.001) groups; the frequency of depressed patients was comparable between the 2 groups. Adjusting for age, sex, income, number of affected individuals per family, and HbS levels, mild-moderate (P=0.042; odds ratio=2.00; 95% confidence interval=1.03-3.91) and severe-extremely severe (P=0.004; odds ratio=4.43; 95% confidence interval=1.59-12.34) anxiety were independently associated with VOC. Both depression and stress were not associated with VOC after adjusting for these covariates. These results suggest a positive contribution of VOC to the increased rates of anxiety disorders among SCA patients, thereby recommending counseling SCA patients with repeated VOC for these psychologic comorbidities, in particular anxiety.

Authors+Show Affiliations

Department of Pediatrics, Salmaniya Medical Complex, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20485202

Citation

Mahdi, Najat, et al. "Depression, Anxiety, and Stress Comorbidities in Sickle Cell Anemia Patients With Vaso-occlusive Crisis." Journal of Pediatric Hematology/oncology, vol. 32, no. 5, 2010, pp. 345-9.
Mahdi N, Al-Ola K, Khalek NA, et al. Depression, anxiety, and stress comorbidities in sickle cell anemia patients with vaso-occlusive crisis. J Pediatr Hematol Oncol. 2010;32(5):345-9.
Mahdi, N., Al-Ola, K., Khalek, N. A., & Almawi, W. Y. (2010). Depression, anxiety, and stress comorbidities in sickle cell anemia patients with vaso-occlusive crisis. Journal of Pediatric Hematology/oncology, 32(5), 345-9. https://doi.org/10.1097/MPH.0b013e3181d869d5
Mahdi N, et al. Depression, Anxiety, and Stress Comorbidities in Sickle Cell Anemia Patients With Vaso-occlusive Crisis. J Pediatr Hematol Oncol. 2010;32(5):345-9. PubMed PMID: 20485202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression, anxiety, and stress comorbidities in sickle cell anemia patients with vaso-occlusive crisis. AU - Mahdi,Najat, AU - Al-Ola,Khadija, AU - Khalek,Nahed Abdel, AU - Almawi,Wassim Y, PY - 2010/5/21/entrez PY - 2010/5/21/pubmed PY - 2010/8/4/medline SP - 345 EP - 9 JF - Journal of pediatric hematology/oncology JO - J. Pediatr. Hematol. Oncol. VL - 32 IS - 5 N2 - We investigated the association of sickle cell anemia (SCA) vaso-occlusive crisis (VOC) with depression, anxiety, and stress disorders among Bahraini patients and controls. This was a cross-sectional study that involved administering Depression Anxiety Stress Scales (DASS-21) consisting of structured depression, anxiety, and stress scales to SCA patients with (n=138) and without (n=105) VOC. Multinomial regression and correlation analysis were used in assessing the association of VOC with depression and/or anxiety and/or stress, after adjusting for other covariates. Significantly higher proportion of VOC patients was found among the severe-extremely severe anxiety (P<0.002) and stress (P=0.001) groups; the frequency of depressed patients was comparable between the 2 groups. Adjusting for age, sex, income, number of affected individuals per family, and HbS levels, mild-moderate (P=0.042; odds ratio=2.00; 95% confidence interval=1.03-3.91) and severe-extremely severe (P=0.004; odds ratio=4.43; 95% confidence interval=1.59-12.34) anxiety were independently associated with VOC. Both depression and stress were not associated with VOC after adjusting for these covariates. These results suggest a positive contribution of VOC to the increased rates of anxiety disorders among SCA patients, thereby recommending counseling SCA patients with repeated VOC for these psychologic comorbidities, in particular anxiety. SN - 1536-3678 UR - https://www.unboundmedicine.com/medline/citation/20485202/Depression_anxiety_and_stress_comorbidities_in_sickle_cell_anemia_patients_with_vaso_occlusive_crisis_ L2 - http://dx.doi.org/10.1097/MPH.0b013e3181d869d5 DB - PRIME DP - Unbound Medicine ER -