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Chronic hepatitis E in liver transplant recipients: a significant clinical problem?
Minerva Gastroenterol Dietol. 2010 Jun; 56(2):121-8.MG

Abstract

Hepatitis E is an inflammatory liver disease caused by infection with the hepatitis E virus (HEV). Five different HEV genotypes have been described. While HEV genotypes 1 and 2 primarily infect man, genotypes 3 and 4 have been detected both in humans and several animal species including pigs. HEV genotype 1 and 2 infections are frequent in Southern Asia and Africa. However, Hepatitis E is more and more considered as an re-emerging zoonotic disease also in industrialized countries as HEV genotype 3 infections seem to increase in Western Europe and North America. Acute hepatitis E usually takes an acute self limited course but may take a fulminant course in particular in pregnant women and patients with pre-existing chronic liver disease. Several cases of persistent HEV-infection have been reported in immunosuppressed patients during the last three years being associated with progressive liver disease in some patients. Thus, screening for HEV RNA should be part of the diagnostic work-up of elevated liver transaminases in organ transplantation recipients or HIV-infected individuals. In this review we summarize the recent data on hepatitis E with a particular focus on the importance of persistent HEV infections in liver transplant recipients.

Authors+Show Affiliations

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. pischke.sven@mh-hannover.deNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20485250

Citation

Pischke, S, and H Wedemeyer. "Chronic Hepatitis E in Liver Transplant Recipients: a Significant Clinical Problem?" Minerva Gastroenterologica E Dietologica, vol. 56, no. 2, 2010, pp. 121-8.
Pischke S, Wedemeyer H. Chronic hepatitis E in liver transplant recipients: a significant clinical problem? Minerva Gastroenterol Dietol. 2010;56(2):121-8.
Pischke, S., & Wedemeyer, H. (2010). Chronic hepatitis E in liver transplant recipients: a significant clinical problem? Minerva Gastroenterologica E Dietologica, 56(2), 121-8.
Pischke S, Wedemeyer H. Chronic Hepatitis E in Liver Transplant Recipients: a Significant Clinical Problem. Minerva Gastroenterol Dietol. 2010;56(2):121-8. PubMed PMID: 20485250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic hepatitis E in liver transplant recipients: a significant clinical problem? AU - Pischke,S, AU - Wedemeyer,H, PY - 2010/5/21/entrez PY - 2010/5/21/pubmed PY - 2010/9/21/medline SP - 121 EP - 8 JF - Minerva gastroenterologica e dietologica JO - Minerva Gastroenterol Dietol VL - 56 IS - 2 N2 - Hepatitis E is an inflammatory liver disease caused by infection with the hepatitis E virus (HEV). Five different HEV genotypes have been described. While HEV genotypes 1 and 2 primarily infect man, genotypes 3 and 4 have been detected both in humans and several animal species including pigs. HEV genotype 1 and 2 infections are frequent in Southern Asia and Africa. However, Hepatitis E is more and more considered as an re-emerging zoonotic disease also in industrialized countries as HEV genotype 3 infections seem to increase in Western Europe and North America. Acute hepatitis E usually takes an acute self limited course but may take a fulminant course in particular in pregnant women and patients with pre-existing chronic liver disease. Several cases of persistent HEV-infection have been reported in immunosuppressed patients during the last three years being associated with progressive liver disease in some patients. Thus, screening for HEV RNA should be part of the diagnostic work-up of elevated liver transaminases in organ transplantation recipients or HIV-infected individuals. In this review we summarize the recent data on hepatitis E with a particular focus on the importance of persistent HEV infections in liver transplant recipients. SN - 1121-421X UR - https://www.unboundmedicine.com/medline/citation/20485250/Chronic_hepatitis_E_in_liver_transplant_recipients:_a_significant_clinical_problem L2 - http://www.minervamedica.it/index2.t?show=R08Y2010N02A0121 DB - PRIME DP - Unbound Medicine ER -