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Alcohol intake and endometrial cancer risk: a meta-analysis of prospective studies.

Abstract

BACKGROUND

Studies on alcohol intake in relation to endometrial cancer risk have produced inconsistent results.

METHODS

For a meta-analysis, we identified cohort studies of alcohol and endometrial cancer by a literature search of Pub-Med and Embase up to 1 March 2010 and by searching the reference lists of relevant articles.

RESULTS

Seven cohort studies, including 1,511,661 participants and 6086 endometrial cancer cases, were included in the dose-response random-effect meta-regression model. Compared with non-drinkers, women drinking less than 1 drink of alcohol (13 g of ethanol) per day had a lower risk for endometrial cancer; this risk was lower by 4% (95% confidence interval (95% CI): 0.93-1.00) for consumption up to 0.5 drink per day and by 7% (95% CI: 0.85-1.02) for consumption up to 1 drink. However, we found evidence of an increased risk for endometrial cancer for intakes higher than two alcoholic drinks per day: compared with non-drinkers, the risk was higher by 14% (95% CI: 0.95-1.36) for 2-2.5 drinks per day and by 25% (95% CI: 0.98-1.58) for >2.5 drinks per day.

CONCLUSION

Our meta-analysis indicates a possible J-shaped relationship between alcohol intake and endometrial cancer risk.

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  • Authors+Show Affiliations

    ,

    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. emilie.friberg@ki.se

    , ,

    Source

    British journal of cancer 103:1 2010 Jun 29 pg 127-31

    MeSH

    Alcohol Drinking
    Cohort Studies
    Endometrial Neoplasms
    Female
    Humans
    Prospective Studies
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20485288

    Citation

    Friberg, E, et al. "Alcohol Intake and Endometrial Cancer Risk: a Meta-analysis of Prospective Studies." British Journal of Cancer, vol. 103, no. 1, 2010, pp. 127-31.
    Friberg E, Orsini N, Mantzoros CS, et al. Alcohol intake and endometrial cancer risk: a meta-analysis of prospective studies. Br J Cancer. 2010;103(1):127-31.
    Friberg, E., Orsini, N., Mantzoros, C. S., & Wolk, A. (2010). Alcohol intake and endometrial cancer risk: a meta-analysis of prospective studies. British Journal of Cancer, 103(1), pp. 127-31. doi:10.1038/sj.bjc.6605698.
    Friberg E, et al. Alcohol Intake and Endometrial Cancer Risk: a Meta-analysis of Prospective Studies. Br J Cancer. 2010 Jun 29;103(1):127-31. PubMed PMID: 20485288.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol intake and endometrial cancer risk: a meta-analysis of prospective studies. AU - Friberg,E, AU - Orsini,N, AU - Mantzoros,C S, AU - Wolk,A, Y1 - 2010/05/18/ PY - 2010/5/21/entrez PY - 2010/5/21/pubmed PY - 2010/7/14/medline SP - 127 EP - 31 JF - British journal of cancer JO - Br. J. Cancer VL - 103 IS - 1 N2 - BACKGROUND: Studies on alcohol intake in relation to endometrial cancer risk have produced inconsistent results. METHODS: For a meta-analysis, we identified cohort studies of alcohol and endometrial cancer by a literature search of Pub-Med and Embase up to 1 March 2010 and by searching the reference lists of relevant articles. RESULTS: Seven cohort studies, including 1,511,661 participants and 6086 endometrial cancer cases, were included in the dose-response random-effect meta-regression model. Compared with non-drinkers, women drinking less than 1 drink of alcohol (13 g of ethanol) per day had a lower risk for endometrial cancer; this risk was lower by 4% (95% confidence interval (95% CI): 0.93-1.00) for consumption up to 0.5 drink per day and by 7% (95% CI: 0.85-1.02) for consumption up to 1 drink. However, we found evidence of an increased risk for endometrial cancer for intakes higher than two alcoholic drinks per day: compared with non-drinkers, the risk was higher by 14% (95% CI: 0.95-1.36) for 2-2.5 drinks per day and by 25% (95% CI: 0.98-1.58) for >2.5 drinks per day. CONCLUSION: Our meta-analysis indicates a possible J-shaped relationship between alcohol intake and endometrial cancer risk. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/20485288/full_citation L2 - http://dx.doi.org/10.1038/sj.bjc.6605698 DB - PRIME DP - Unbound Medicine ER -