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Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum.
Planta Med. 2010 Nov; 76(16):1910-4.PM

Abstract

Two new alkaloids chaetoglobosins V (1) and W (2), together with the six known congeners 3-8, were isolated through bioassay-guided fractionations from the EtOAc extract of a solid culture of Chaetomium globosum IFB-E041. The structures were elucidated by spectroscopic methods including mainly 1D and 2D NMR techniques. Chaetoglobosin W (2) was unique in its possession of an oxolane ring formed via an oxygen bridge between C-3 and C-6. The isolated fungal metabolites exhibited moderate cytotoxic activities against four human cancer cell lines (KB, K562, MCF-7, and HepG2) with their IC(50) values in a range of 18-30 µg/mL.

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Authors+Show Affiliations

Zhang J
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
Ge HM
No affiliation info available
Jiao RH
No affiliation info available
Li J
No affiliation info available
Peng H
No affiliation info available
Wang YR
No affiliation info available
Wu JH
No affiliation info available
Song YC
No affiliation info available
Tan RX
No affiliation info available

MeSH

Antineoplastic AgentsArtemisia annuaBiological ProductsCell Line, TumorChaetomiumHumansIndole AlkaloidsNeoplasms

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20486076

Citation

Zhang, Jie, et al. "Cytotoxic Chaetoglobosins From the Endophyte Chaetomium Globosum." Planta Medica, vol. 76, no. 16, 2010, pp. 1910-4.
Zhang J, Ge HM, Jiao RH, et al. Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. Planta Med. 2010;76(16):1910-4.
Zhang, J., Ge, H. M., Jiao, R. H., Li, J., Peng, H., Wang, Y. R., Wu, J. H., Song, Y. C., & Tan, R. X. (2010). Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. Planta Medica, 76(16), 1910-4. https://doi.org/10.1055/s-0030-1249936
Zhang J, et al. Cytotoxic Chaetoglobosins From the Endophyte Chaetomium Globosum. Planta Med. 2010;76(16):1910-4. PubMed PMID: 20486076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. AU - Zhang,Jie, AU - Ge,Hui Ming, AU - Jiao,Rui Hua, AU - Li,Jing, AU - Peng,Hui, AU - Wang,Yu Rong, AU - Wu,Jun Hua, AU - Song,Yong Chun, AU - Tan,Ren Xiang, Y1 - 2010/05/19/ PY - 2010/5/21/entrez PY - 2010/5/21/pubmed PY - 2011/5/3/medline SP - 1910 EP - 4 JF - Planta medica JO - Planta Med VL - 76 IS - 16 N2 - Two new alkaloids chaetoglobosins V (1) and W (2), together with the six known congeners 3-8, were isolated through bioassay-guided fractionations from the EtOAc extract of a solid culture of Chaetomium globosum IFB-E041. The structures were elucidated by spectroscopic methods including mainly 1D and 2D NMR techniques. Chaetoglobosin W (2) was unique in its possession of an oxolane ring formed via an oxygen bridge between C-3 and C-6. The isolated fungal metabolites exhibited moderate cytotoxic activities against four human cancer cell lines (KB, K562, MCF-7, and HepG2) with their IC(50) values in a range of 18-30 µg/mL. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/20486076/Cytotoxic_chaetoglobosins_from_the_endophyte_Chaetomium_globosum_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0030-1249936 DB - PRIME DP - Unbound Medicine ER -