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Antidepressant-like pharmacological profile of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene: Involvement of serotonergic system.
Neuropharmacology. 2010 Sep; 59(3):172-9.N

Abstract

This study evaluated the effect of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene (DPS) in the mouse forced swim test (FST) and tail suspension test (TST), two assays predictive of depressant activity. The involvement of serotonergic system in the effect caused by DPS was studied. The antidepressant-like effect of combined treatment with subeffetive doses of DPS and paroxetine, a selective serotonin reuptake inhibitor (SSRI) was investigated. Further, we verified the possible mechanism responsible for antidepressive-like effect of DPS. The results show that DPS (50 and 100 mg/kg, p.o.) significantly reduced the immobility time during the FST and TST, without accompanying changes in ambulation when assessed in the open-field test. The anti-immobility effect of DPS (50 mg/kg, p.o.) in the FST was prevented by pretreatment of mice with pCPA (100 mg/kg, i.p., once a day for 4 consecutive days, an inhibitor of 5-HT synthesis), WAY 100635 (0.1 mg/kg, s.c., a selective 5-HT1A receptor antagonist), ritanserin (1 mg/kg, i.p., a 5-HT2 receptor antagonist) or ondansetron (1 mg/kg, i.p., a 5-HT3 receptor antagonist). Combined treatment with paroxetine and DPS reduced the immobility time in the FST. DPS at the doses of 10-100 mg/kg did not produce any change in the cerebral activity of MAO-A or MAO-B. DPS at the dose of 50 mg/kg inhibited significantly 5-HT uptake in synaptosomes. These results suggest that DPS produced an antidepressant-like effect in the mouse FST and TST and this effect seems most likely to be mediated through an interaction with serotonergic system, particularly by 5-HT reuptake inhibition.

Authors+Show Affiliations

Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria CEP 97105-900, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20488195

Citation

Gay, Bibiana M., et al. "Antidepressant-like Pharmacological Profile of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene: Involvement of Serotonergic System." Neuropharmacology, vol. 59, no. 3, 2010, pp. 172-9.
Gay BM, Prigol M, Stein AL, et al. Antidepressant-like pharmacological profile of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene: Involvement of serotonergic system. Neuropharmacology. 2010;59(3):172-9.
Gay, B. M., Prigol, M., Stein, A. L., & Nogueira, C. W. (2010). Antidepressant-like pharmacological profile of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene: Involvement of serotonergic system. Neuropharmacology, 59(3), 172-9. https://doi.org/10.1016/j.neuropharm.2010.05.003
Gay BM, et al. Antidepressant-like Pharmacological Profile of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene: Involvement of Serotonergic System. Neuropharmacology. 2010;59(3):172-9. PubMed PMID: 20488195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like pharmacological profile of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene: Involvement of serotonergic system. AU - Gay,Bibiana M, AU - Prigol,Marina, AU - Stein,André L, AU - Nogueira,Cristina W, Y1 - 2010/05/19/ PY - 2009/12/17/received PY - 2010/05/10/revised PY - 2010/05/10/accepted PY - 2010/5/22/entrez PY - 2010/5/22/pubmed PY - 2010/10/15/medline SP - 172 EP - 9 JF - Neuropharmacology JO - Neuropharmacology VL - 59 IS - 3 N2 - This study evaluated the effect of 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene (DPS) in the mouse forced swim test (FST) and tail suspension test (TST), two assays predictive of depressant activity. The involvement of serotonergic system in the effect caused by DPS was studied. The antidepressant-like effect of combined treatment with subeffetive doses of DPS and paroxetine, a selective serotonin reuptake inhibitor (SSRI) was investigated. Further, we verified the possible mechanism responsible for antidepressive-like effect of DPS. The results show that DPS (50 and 100 mg/kg, p.o.) significantly reduced the immobility time during the FST and TST, without accompanying changes in ambulation when assessed in the open-field test. The anti-immobility effect of DPS (50 mg/kg, p.o.) in the FST was prevented by pretreatment of mice with pCPA (100 mg/kg, i.p., once a day for 4 consecutive days, an inhibitor of 5-HT synthesis), WAY 100635 (0.1 mg/kg, s.c., a selective 5-HT1A receptor antagonist), ritanserin (1 mg/kg, i.p., a 5-HT2 receptor antagonist) or ondansetron (1 mg/kg, i.p., a 5-HT3 receptor antagonist). Combined treatment with paroxetine and DPS reduced the immobility time in the FST. DPS at the doses of 10-100 mg/kg did not produce any change in the cerebral activity of MAO-A or MAO-B. DPS at the dose of 50 mg/kg inhibited significantly 5-HT uptake in synaptosomes. These results suggest that DPS produced an antidepressant-like effect in the mouse FST and TST and this effect seems most likely to be mediated through an interaction with serotonergic system, particularly by 5-HT reuptake inhibition. SN - 1873-7064 UR - https://www.unboundmedicine.com/medline/citation/20488195/Antidepressant_like_pharmacological_profile_of_3__4_fluorophenylselenyl__25_diphenylselenophene:_Involvement_of_serotonergic_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3908(10)00128-0 DB - PRIME DP - Unbound Medicine ER -