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Anticholinergic drug use and mortality among residents of long-term care facilities: a prospective cohort study.
J Clin Pharmacol. 2011 Feb; 51(2):256-63.JC

Abstract

Few studies have investigated the possible association between use of anticholinergic drugs and mortality. The objectives of this study were to investigate the prevalence and determinants of anticholinergic drug use and the possible association between anticholinergic drug use and mortality. Data were obtained from 53 long-term care wards in Helsinki, Finland, in 2003. Medication, diagnostic, and mortality data were available for 1004 residents. Each resident's anticholinergic load was calculated using the Anticholinergic Risk Scale (ARS). Cox proportional hazards models were used to investigate the risk of death among users with a mild anticholinergic load (ARS score 1-2) and high load (ARS score ≥3) compared with nonusers of anticholinergic drugs. Age, sex, and nutritional status were used as covariates. Among the 1004 residents, 455 (45%) were nonusers of anticholinergic drugs, 363 (36%) had a mild anticholinergic load, and 186 (19%) had a high anticholinergic load. One-year all-cause mortality rates were 28%, 29%, and 27%, respectively. Higher ARS scores were not associated with mortality (ARS score 1-2: hazard ratio 1.08; 95% confidence interval, 0.84-1.41; ARS score ≥3: hazard ratio 1.05; 95% confidence interval, 0.75-1.46). Anticholinergic drug use was common; however, high ARS scores were not associated with mortality. Further research is needed using alternative models and among different resident populations.

Authors+Show Affiliations

Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Box 1627, Kuopio 70211, Finland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20489026

Citation

Kumpula, Eeva-Katri, et al. "Anticholinergic Drug Use and Mortality Among Residents of Long-term Care Facilities: a Prospective Cohort Study." Journal of Clinical Pharmacology, vol. 51, no. 2, 2011, pp. 256-63.
Kumpula EK, Bell JS, Soini H, et al. Anticholinergic drug use and mortality among residents of long-term care facilities: a prospective cohort study. J Clin Pharmacol. 2011;51(2):256-63.
Kumpula, E. K., Bell, J. S., Soini, H., & Pitkälä, K. H. (2011). Anticholinergic drug use and mortality among residents of long-term care facilities: a prospective cohort study. Journal of Clinical Pharmacology, 51(2), 256-63. https://doi.org/10.1177/0091270010368410
Kumpula EK, et al. Anticholinergic Drug Use and Mortality Among Residents of Long-term Care Facilities: a Prospective Cohort Study. J Clin Pharmacol. 2011;51(2):256-63. PubMed PMID: 20489026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anticholinergic drug use and mortality among residents of long-term care facilities: a prospective cohort study. AU - Kumpula,Eeva-Katri, AU - Bell,J Simon, AU - Soini,Helena, AU - Pitkälä,Kaisu H, Y1 - 2010/05/20/ PY - 2010/5/22/entrez PY - 2010/5/22/pubmed PY - 2011/4/22/medline SP - 256 EP - 63 JF - Journal of clinical pharmacology JO - J Clin Pharmacol VL - 51 IS - 2 N2 - Few studies have investigated the possible association between use of anticholinergic drugs and mortality. The objectives of this study were to investigate the prevalence and determinants of anticholinergic drug use and the possible association between anticholinergic drug use and mortality. Data were obtained from 53 long-term care wards in Helsinki, Finland, in 2003. Medication, diagnostic, and mortality data were available for 1004 residents. Each resident's anticholinergic load was calculated using the Anticholinergic Risk Scale (ARS). Cox proportional hazards models were used to investigate the risk of death among users with a mild anticholinergic load (ARS score 1-2) and high load (ARS score ≥3) compared with nonusers of anticholinergic drugs. Age, sex, and nutritional status were used as covariates. Among the 1004 residents, 455 (45%) were nonusers of anticholinergic drugs, 363 (36%) had a mild anticholinergic load, and 186 (19%) had a high anticholinergic load. One-year all-cause mortality rates were 28%, 29%, and 27%, respectively. Higher ARS scores were not associated with mortality (ARS score 1-2: hazard ratio 1.08; 95% confidence interval, 0.84-1.41; ARS score ≥3: hazard ratio 1.05; 95% confidence interval, 0.75-1.46). Anticholinergic drug use was common; however, high ARS scores were not associated with mortality. Further research is needed using alternative models and among different resident populations. SN - 1552-4604 UR - https://www.unboundmedicine.com/medline/citation/20489026/Anticholinergic_drug_use_and_mortality_among_residents_of_long_term_care_facilities:_a_prospective_cohort_study_ L2 - https://doi.org/10.1177/0091270010368410 DB - PRIME DP - Unbound Medicine ER -