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Diabetes, prediabetes and cancer mortality.
Diabetologia. 2010 Sep; 53(9):1867-76.D

Abstract

AIMS/HYPOTHESIS

We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT.

METHODS

Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed for 5.9 to 36.8 years. Cox proportional hazards analysis with adjustment for cohort, age, BMI, total cholesterol, blood pressure and smoking status was used to estimate HRs for cancer mortality.

RESULTS

Compared with people in the normal glucose category, multivariable adjusted HRs (95% CI) for cancer mortality were 1.13 (1.00, 1.28), 1.27 (1.02, 1.57) and 1.71 (1.35, 2.17) in men with prediabetes, previously undiagnosed diabetes and known diabetes, respectively; in women they were 1.11 (0.94, 1.30), 1.31 (1.00, 1.70) and 1.43 (1.01, 2.02), respectively. Significant increases in deaths from cancer of the stomach, colon-rectum and liver in men with prediabetes and diabetes, and deaths from cancers of the liver and pancreas in women with diabetes were also observed. In individuals without known diabetes, the HR (95% CI) for cancer mortality corresponding to a one standard deviation increase in fasting plasma glucose was 1.06 (1.02, 1.09) and in 2 h plasma glucose was 1.07 (1.03, 1.11).

CONCLUSIONS/INTERPRETATION

Diabetes and prediabetes were associated with an increased risk of cancer death, particularly death from liver cancer. Mortality from all cancers rose linearly with increasing glucose concentrations.

Authors+Show Affiliations

Department of Public Health, University of Helsinki, PL41, Mannerheimintie 172, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20490448

Citation

Zhou, X H., et al. "Diabetes, Prediabetes and Cancer Mortality." Diabetologia, vol. 53, no. 9, 2010, pp. 1867-76.
Zhou XH, Qiao Q, Zethelius B, et al. Diabetes, prediabetes and cancer mortality. Diabetologia. 2010;53(9):1867-76.
Zhou, X. H., Qiao, Q., Zethelius, B., Pyörälä, K., Söderberg, S., Pajak, A., Stehouwer, C. D., Heine, R. J., Jousilahti, P., Ruotolo, G., Nilsson, P. M., Calori, G., & Tuomilehto, J. (2010). Diabetes, prediabetes and cancer mortality. Diabetologia, 53(9), 1867-76. https://doi.org/10.1007/s00125-010-1796-7
Zhou XH, et al. Diabetes, Prediabetes and Cancer Mortality. Diabetologia. 2010;53(9):1867-76. PubMed PMID: 20490448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetes, prediabetes and cancer mortality. AU - Zhou,X H, AU - Qiao,Q, AU - Zethelius,B, AU - Pyörälä,K, AU - Söderberg,S, AU - Pajak,A, AU - Stehouwer,C D A, AU - Heine,R J, AU - Jousilahti,P, AU - Ruotolo,G, AU - Nilsson,P M, AU - Calori,G, AU - Tuomilehto,J, AU - ,, Y1 - 2010/05/21/ PY - 2010/02/08/received PY - 2010/04/16/accepted PY - 2010/5/22/entrez PY - 2010/5/22/pubmed PY - 2010/11/5/medline SP - 1867 EP - 76 JF - Diabetologia JO - Diabetologia VL - 53 IS - 9 N2 - AIMS/HYPOTHESIS: We aimed to investigate the risk of cancer mortality in relation to the glucose tolerance status classified according to the 2 h OGTT. METHODS: Data from 17 European population-based or occupational cohorts involved in the DECODE study comprising 26,460 men and 18,195 women aged 25-90 years were collaboratively analysed. The cohorts were recruited between 1966 and 2004 and followed for 5.9 to 36.8 years. Cox proportional hazards analysis with adjustment for cohort, age, BMI, total cholesterol, blood pressure and smoking status was used to estimate HRs for cancer mortality. RESULTS: Compared with people in the normal glucose category, multivariable adjusted HRs (95% CI) for cancer mortality were 1.13 (1.00, 1.28), 1.27 (1.02, 1.57) and 1.71 (1.35, 2.17) in men with prediabetes, previously undiagnosed diabetes and known diabetes, respectively; in women they were 1.11 (0.94, 1.30), 1.31 (1.00, 1.70) and 1.43 (1.01, 2.02), respectively. Significant increases in deaths from cancer of the stomach, colon-rectum and liver in men with prediabetes and diabetes, and deaths from cancers of the liver and pancreas in women with diabetes were also observed. In individuals without known diabetes, the HR (95% CI) for cancer mortality corresponding to a one standard deviation increase in fasting plasma glucose was 1.06 (1.02, 1.09) and in 2 h plasma glucose was 1.07 (1.03, 1.11). CONCLUSIONS/INTERPRETATION: Diabetes and prediabetes were associated with an increased risk of cancer death, particularly death from liver cancer. Mortality from all cancers rose linearly with increasing glucose concentrations. SN - 1432-0428 UR - https://www.unboundmedicine.com/medline/citation/20490448/Diabetes_prediabetes_and_cancer_mortality_ L2 - https://doi.org/10.1007/s00125-010-1796-7 DB - PRIME DP - Unbound Medicine ER -