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[The role of macrolides in treatment of exacerbations of chronic obstructive pulmonary disease].
Pol Merkur Lekarski 2010; 28(166):311-4PM

Abstract

Exacerbations of chronic obstructive pulmonary disease (COPD) cause a lot of hospital admissions, mortality, and strongly influence health-related quality of life. Approximately half of COPD exacerbations are associated with bacterial infections and many patients have lower airways colonization. Current guidelines recommend antibotic therapy in course of COPD exacerbation for patients with sputum purulence and suggest correlation between severity of symptoms and the type of infecting pathogen. The most common bacterial pathogens isolated in COPD exacerbation are Haemophilus influenzae and parainfluenzae, Streptococcus pneumoniae and Moraxella catarrhalis. The presence of these bacteria are more common for mild and moderate exacerbations. More virulent organisms such as Staphylococcus aureus and Pseudomonas aeruginosa have been found in more severe cases. Atypical pathogens such Chlamydophila and Mycoplasma could cause exacerbation alone or they could coexist with typical pathogen. Rules of antibiotic therapy and usefulness of macrolides in treatment of COPD exacerbation has been described in the article.

Authors+Show Affiliations

Wojskowy Instytut Medyczny w Warszawie, Centralny Szpital Kliniczny MON, 1Klinika Chorób Wewnetrznych, Pneumonologii i Alergologii. targowski.tomasz_xl@wp.plNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

pol

PubMed ID

20491344

Citation

Targowski, Tomasz, and Karina Jahnz-Rózyk. "[The Role of Macrolides in Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 28, no. 166, 2010, pp. 311-4.
Targowski T, Jahnz-Rózyk K. [The role of macrolides in treatment of exacerbations of chronic obstructive pulmonary disease]. Pol Merkur Lekarski. 2010;28(166):311-4.
Targowski, T., & Jahnz-Rózyk, K. (2010). [The role of macrolides in treatment of exacerbations of chronic obstructive pulmonary disease]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 28(166), pp. 311-4.
Targowski T, Jahnz-Rózyk K. [The Role of Macrolides in Treatment of Exacerbations of Chronic Obstructive Pulmonary Disease]. Pol Merkur Lekarski. 2010;28(166):311-4. PubMed PMID: 20491344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of macrolides in treatment of exacerbations of chronic obstructive pulmonary disease]. AU - Targowski,Tomasz, AU - Jahnz-Rózyk,Karina, PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/7/3/medline SP - 311 EP - 4 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 28 IS - 166 N2 - Exacerbations of chronic obstructive pulmonary disease (COPD) cause a lot of hospital admissions, mortality, and strongly influence health-related quality of life. Approximately half of COPD exacerbations are associated with bacterial infections and many patients have lower airways colonization. Current guidelines recommend antibotic therapy in course of COPD exacerbation for patients with sputum purulence and suggest correlation between severity of symptoms and the type of infecting pathogen. The most common bacterial pathogens isolated in COPD exacerbation are Haemophilus influenzae and parainfluenzae, Streptococcus pneumoniae and Moraxella catarrhalis. The presence of these bacteria are more common for mild and moderate exacerbations. More virulent organisms such as Staphylococcus aureus and Pseudomonas aeruginosa have been found in more severe cases. Atypical pathogens such Chlamydophila and Mycoplasma could cause exacerbation alone or they could coexist with typical pathogen. Rules of antibiotic therapy and usefulness of macrolides in treatment of COPD exacerbation has been described in the article. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/20491344/[The_role_of_macrolides_in_treatment_of_exacerbations_of_chronic_obstructive_pulmonary_disease]_ L2 - http://www.diseaseinfosearch.org/result/7979 DB - PRIME DP - Unbound Medicine ER -