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Structures and antimicrobial activities of pyridoacridine alkaloids isolated from different chromotypes of the ascidian Cystodytes dellechiajei.
J Nat Prod. 2010 Jun 25; 73(6):1044-8.JN

Abstract

Three new pentacyclic alkaloids were isolated from different chromotypes of the western Mediterranean ascidian Cystodytes dellechiajei. The purple color morph collected in Catalonia contained the known compounds kuanoniamine D (1), shermilamine B (2), N-deacetylkuanoniamine D (3), and styelsamine C (4) and a new alkaloid named N-deacetylshermilamine B (5). The green color morph collected in the Balearic Islands contained the known compounds 11-hydroxyascididemin (6) and 8,9-dihydro-11-hydroxyascididemin (7) and two new alkaloids named cystodimine A (8) and cystodimine B (9). The blue color morph collected in Catalonia yielded the known compound ascididemin (10). The structures of all compounds were elucidated on the basis of spectroscopic data, mainly 1D and 2D NMR data. The antimicrobial potential of the pyridoacridine alkaloids isolated from each color morph was evaluated and compared.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Bontemps N
Laboratoire de Chimie des Biomolecules et de l'Environnement, University of Perpignan via Domitia, 52 Paul Alduy Avenue, 66860 Perpignan Cedex, France. bontemps@univ-perp.fr
Bry D
No affiliation info available
López-Legentil S
No affiliation info available
Simon-Levert A
No affiliation info available
Long C
No affiliation info available
Banaigs B
No affiliation info available

MeSH

AcridinesAlkaloidsAnimalsAnti-Bacterial AgentsEscherichia coliMicrobial Sensitivity TestsMicrococcus luteusMolecular StructureNuclear Magnetic Resonance, BiomolecularPhenanthrolinesUrochordata

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20491501

Citation

Bontemps, N, et al. "Structures and Antimicrobial Activities of Pyridoacridine Alkaloids Isolated From Different Chromotypes of the Ascidian Cystodytes Dellechiajei." Journal of Natural Products, vol. 73, no. 6, 2010, pp. 1044-8.
Bontemps N, Bry D, López-Legentil S, et al. Structures and antimicrobial activities of pyridoacridine alkaloids isolated from different chromotypes of the ascidian Cystodytes dellechiajei. J Nat Prod. 2010;73(6):1044-8.
Bontemps, N., Bry, D., López-Legentil, S., Simon-Levert, A., Long, C., & Banaigs, B. (2010). Structures and antimicrobial activities of pyridoacridine alkaloids isolated from different chromotypes of the ascidian Cystodytes dellechiajei. Journal of Natural Products, 73(6), 1044-8. https://doi.org/10.1021/np900751k
Bontemps N, et al. Structures and Antimicrobial Activities of Pyridoacridine Alkaloids Isolated From Different Chromotypes of the Ascidian Cystodytes Dellechiajei. J Nat Prod. 2010 Jun 25;73(6):1044-8. PubMed PMID: 20491501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structures and antimicrobial activities of pyridoacridine alkaloids isolated from different chromotypes of the ascidian Cystodytes dellechiajei. AU - Bontemps,N, AU - Bry,D, AU - López-Legentil,S, AU - Simon-Levert,A, AU - Long,C, AU - Banaigs,B, PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/7/31/medline SP - 1044 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 73 IS - 6 N2 - Three new pentacyclic alkaloids were isolated from different chromotypes of the western Mediterranean ascidian Cystodytes dellechiajei. The purple color morph collected in Catalonia contained the known compounds kuanoniamine D (1), shermilamine B (2), N-deacetylkuanoniamine D (3), and styelsamine C (4) and a new alkaloid named N-deacetylshermilamine B (5). The green color morph collected in the Balearic Islands contained the known compounds 11-hydroxyascididemin (6) and 8,9-dihydro-11-hydroxyascididemin (7) and two new alkaloids named cystodimine A (8) and cystodimine B (9). The blue color morph collected in Catalonia yielded the known compound ascididemin (10). The structures of all compounds were elucidated on the basis of spectroscopic data, mainly 1D and 2D NMR data. The antimicrobial potential of the pyridoacridine alkaloids isolated from each color morph was evaluated and compared. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/20491501/Structures_and_antimicrobial_activities_of_pyridoacridine_alkaloids_isolated_from_different_chromotypes_of_the_ascidian_Cystodytes_dellechiajei_ L2 - https://doi.org/10.1021/np900751k DB - PRIME DP - Unbound Medicine ER -