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Avidity of thyroglobulin antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status.
Clin Exp Immunol 2010; 161(1):65-70CE

Abstract

The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) is a diagnostic hallmark of HT. The aim of our study was to evaluate the avidity of TgAb in sera from HT patients with different thyroid functional status. Sera from 50 patients with newly diagnosed HT were collected and divided into three groups according to thyroid function: patients with hypothyroidism (H, n=18), subclinical hypothyroidism (sH, n=18) and euthyroidism (Eu, n=14). Titres and avidity of TgAb were determined by enzyme-linked immunosorbent assays (ELISAs). Avidity constant (aK) was determined as the reciprocal value of the thyroglobulin molar concentration in the liquid phase resulting in 50% inhibition of TgAb binding to thyroglobulin in solid-phase ELISAs. The titres and aK of TgAb were performed using log-transformation, and expressed as lgT and lgaK, respectively. Mean lgT of TgAb in sera was 4.19+/-0.60 in H, 3.77+/-0.63 in sH, and 3.29+/-0.64 in Eu, respectively. The median avidity of TgAb was 2.30x10(9) in H, 8.80x10(8) in sH, 2.00x10(7) in Eu, respectively. lgT and lgaK of TgAb were at significantly lower levels in Eu than in sH and H (P<0.05). Correlation was found between lgT and lgaK (r=0.594, P<0.05). lgaK was also related to TSH (r=0.308, P<0.05). Our study indicated that patients with high-avidity TgAb might be at high risk of developing subclinical, even to overt, hypothyroidism.

Authors+Show Affiliations

Department of Endocrinology, University First Hospital, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20491790

Citation

Zhang, Y, et al. "Avidity of Thyroglobulin Antibody in Sera From Patients With Hashimoto's Thyroiditis With Different Thyroid Functional Status." Clinical and Experimental Immunology, vol. 161, no. 1, 2010, pp. 65-70.
Zhang Y, Gao Y, Li M, et al. Avidity of thyroglobulin antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status. Clin Exp Immunol. 2010;161(1):65-70.
Zhang, Y., Gao, Y., Li, M., Xie, L., Huang, Y., Gao, Y., & Guo, X. (2010). Avidity of thyroglobulin antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status. Clinical and Experimental Immunology, 161(1), pp. 65-70. doi:10.1111/j.1365-2249.2010.04155.x.
Zhang Y, et al. Avidity of Thyroglobulin Antibody in Sera From Patients With Hashimoto's Thyroiditis With Different Thyroid Functional Status. Clin Exp Immunol. 2010 Jul 1;161(1):65-70. PubMed PMID: 20491790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Avidity of thyroglobulin antibody in sera from patients with Hashimoto's thyroiditis with different thyroid functional status. AU - Zhang,Y, AU - Gao,Y, AU - Li,M, AU - Xie,L, AU - Huang,Y, AU - Gao,Y, AU - Guo,X, Y1 - 2010/05/10/ PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/8/3/medline SP - 65 EP - 70 JF - Clinical and experimental immunology JO - Clin. Exp. Immunol. VL - 161 IS - 1 N2 - The mechanism of disease progression in Hashimoto's thyroiditis (HT) is still unclear. Thyroglobulin antibody (TgAb) is a diagnostic hallmark of HT. The aim of our study was to evaluate the avidity of TgAb in sera from HT patients with different thyroid functional status. Sera from 50 patients with newly diagnosed HT were collected and divided into three groups according to thyroid function: patients with hypothyroidism (H, n=18), subclinical hypothyroidism (sH, n=18) and euthyroidism (Eu, n=14). Titres and avidity of TgAb were determined by enzyme-linked immunosorbent assays (ELISAs). Avidity constant (aK) was determined as the reciprocal value of the thyroglobulin molar concentration in the liquid phase resulting in 50% inhibition of TgAb binding to thyroglobulin in solid-phase ELISAs. The titres and aK of TgAb were performed using log-transformation, and expressed as lgT and lgaK, respectively. Mean lgT of TgAb in sera was 4.19+/-0.60 in H, 3.77+/-0.63 in sH, and 3.29+/-0.64 in Eu, respectively. The median avidity of TgAb was 2.30x10(9) in H, 8.80x10(8) in sH, 2.00x10(7) in Eu, respectively. lgT and lgaK of TgAb were at significantly lower levels in Eu than in sH and H (P<0.05). Correlation was found between lgT and lgaK (r=0.594, P<0.05). lgaK was also related to TSH (r=0.308, P<0.05). Our study indicated that patients with high-avidity TgAb might be at high risk of developing subclinical, even to overt, hypothyroidism. SN - 1365-2249 UR - https://www.unboundmedicine.com/medline/citation/20491790/Avidity_of_thyroglobulin_antibody_in_sera_from_patients_with_Hashimoto's_thyroiditis_with_different_thyroid_functional_status_ L2 - https://doi.org/10.1111/j.1365-2249.2010.04155.x DB - PRIME DP - Unbound Medicine ER -