Tags

Type your tag names separated by a space and hit enter

Correlations among Helicobacter pylori infection and the expression of cyclooxygenase-2 and vascular endothelial growth factor in gastric mucosa with intestinal metaplasia or dysplasia.
J Gastroenterol Hepatol 2010; 25(4):795-9JG

Abstract

BACKGROUND AND AIMS

To examine the rate of Helicobacter pylori infection and the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in gastric mucosa with intestinal metaplasia or dysplasia, and explore their correlations in precancerous gastric lesions.

METHODS

A total of 172 patients were included in the study. H. pylori infection was evaluated by hematoxylin-eosin and modified Giemsa staining. The expression of COX-2 and VEGF proteins was detected by immunohistochemistry.

RESULTS

The rates of H. pylori infection in gastric mucosal dysplasia (DYS), intestinal metaplasia in gastric mucosa (IM), chronic atrophic gastritis (CAG) and chronic superficial gastritis (CSG) patients were significant differences (P = 0.001). The average optical density (AOD) values of COX-2 staining in CSG, CAG, IM and DYS patients were 13.81 +/- 5.53, 45.28 +/- 21.44, 73.67 +/- 26.02 and 91.23 +/- 45.11, respectively, with significant differences among CSG, CAG and IM patients (P = 0.037, 0.001 and 0.047 for CSG vs CAG, CSG vs IM and CAG vs IM, respectively). The expression level of VEGF in DYS patients was significantly higher than those in other patients (P = 0.001, 0.001 and 0.001 for DYS vs CSG, DYS vs CAG and DYS vs IM, respectively). The expression levels of COX-2 in H. pylori-positive IM, CAG and DYS patients were significantly higher than those in H. pylori-negative counterparts (P = 0.043, 0.009, 0.001, respectively). Additionally, the expression level of COX-2 was positively correlated with that of VEGF with the aggravation of gastric mucosal lesions (r = 0.640, P = 0.006).

CONCLUSION

H. pylori infection might be able to induce the expression of COX-2 in precancerous gastric lesions, which in turn upregulates the expression of VEGF.

Authors+Show Affiliations

Department of Gastroenterology of First Affiliated Hospital of China Medical University, Shenyang, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20492336

Citation

Liu, Dongping, et al. "Correlations Among Helicobacter Pylori Infection and the Expression of Cyclooxygenase-2 and Vascular Endothelial Growth Factor in Gastric Mucosa With Intestinal Metaplasia or Dysplasia." Journal of Gastroenterology and Hepatology, vol. 25, no. 4, 2010, pp. 795-9.
Liu D, He Q, Liu C. Correlations among Helicobacter pylori infection and the expression of cyclooxygenase-2 and vascular endothelial growth factor in gastric mucosa with intestinal metaplasia or dysplasia. J Gastroenterol Hepatol. 2010;25(4):795-9.
Liu, D., He, Q., & Liu, C. (2010). Correlations among Helicobacter pylori infection and the expression of cyclooxygenase-2 and vascular endothelial growth factor in gastric mucosa with intestinal metaplasia or dysplasia. Journal of Gastroenterology and Hepatology, 25(4), pp. 795-9. doi:10.1111/j.1440-1746.2009.06168.x.
Liu D, He Q, Liu C. Correlations Among Helicobacter Pylori Infection and the Expression of Cyclooxygenase-2 and Vascular Endothelial Growth Factor in Gastric Mucosa With Intestinal Metaplasia or Dysplasia. J Gastroenterol Hepatol. 2010;25(4):795-9. PubMed PMID: 20492336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlations among Helicobacter pylori infection and the expression of cyclooxygenase-2 and vascular endothelial growth factor in gastric mucosa with intestinal metaplasia or dysplasia. AU - Liu,Dongping, AU - He,Qingjuan, AU - Liu,Caigang, PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/8/31/medline SP - 795 EP - 9 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 25 IS - 4 N2 - BACKGROUND AND AIMS: To examine the rate of Helicobacter pylori infection and the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in gastric mucosa with intestinal metaplasia or dysplasia, and explore their correlations in precancerous gastric lesions. METHODS: A total of 172 patients were included in the study. H. pylori infection was evaluated by hematoxylin-eosin and modified Giemsa staining. The expression of COX-2 and VEGF proteins was detected by immunohistochemistry. RESULTS: The rates of H. pylori infection in gastric mucosal dysplasia (DYS), intestinal metaplasia in gastric mucosa (IM), chronic atrophic gastritis (CAG) and chronic superficial gastritis (CSG) patients were significant differences (P = 0.001). The average optical density (AOD) values of COX-2 staining in CSG, CAG, IM and DYS patients were 13.81 +/- 5.53, 45.28 +/- 21.44, 73.67 +/- 26.02 and 91.23 +/- 45.11, respectively, with significant differences among CSG, CAG and IM patients (P = 0.037, 0.001 and 0.047 for CSG vs CAG, CSG vs IM and CAG vs IM, respectively). The expression level of VEGF in DYS patients was significantly higher than those in other patients (P = 0.001, 0.001 and 0.001 for DYS vs CSG, DYS vs CAG and DYS vs IM, respectively). The expression levels of COX-2 in H. pylori-positive IM, CAG and DYS patients were significantly higher than those in H. pylori-negative counterparts (P = 0.043, 0.009, 0.001, respectively). Additionally, the expression level of COX-2 was positively correlated with that of VEGF with the aggravation of gastric mucosal lesions (r = 0.640, P = 0.006). CONCLUSION: H. pylori infection might be able to induce the expression of COX-2 in precancerous gastric lesions, which in turn upregulates the expression of VEGF. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/20492336/Correlations_among_Helicobacter_pylori_infection_and_the_expression_of_cyclooxygenase_2_and_vascular_endothelial_growth_factor_in_gastric_mucosa_with_intestinal_metaplasia_or_dysplasia_ L2 - https://doi.org/10.1111/j.1440-1746.2009.06168.x DB - PRIME DP - Unbound Medicine ER -