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Long-term treatment of localized gastric marginal zone B-cell mucosa associated lymphoid tissue lymphoma including incidence of metachronous gastric cancer.
J Gastroenterol Hepatol. 2010 Apr; 25(4):804-9.JG

Abstract

BACKGROUND AND AIM

According to a few recent reports on the long-term clinical outcome of gastric marginal zone B-cell mucosa associated lymphoid tissue lymphoma (MALT lymphoma); localized gastric MALT lymphoma generally has a favorable prognosis. However, the risk of metachronous gastric cancer has not been evaluated. In this study, we analyzed long-term outcomes of localized gastric MALT lymphoma including the incidence of metachronous gastric cancer.

METHODS

Between April 1996 and May 2008, 60 patients (31 men and 29 women; mean age 58.1 years) with localized gastric MALT lymphoma (stage I and II(1) according to Lugano classification) were analyzed retrospectively.

RESULTS

Forty-eight patients (82.6%) achieved complete remission by eradication therapy. Radiation therapy was conducted on eight patients as second-line treatment, and all of them achieved remission. The median follow-up period was 76 months (range, 12-157 months). One patient had local relapse after remission for 5 years and three patients developed early gastric cancer without recurrence of lymphoma (5%). All of the three gastric cancers appeared in the same areas where MALT lymphoma had been eradicated.

CONCLUSION

Eradication therapy and radiation therapy for localized gastric MALT lymphoma have a favorable long-term outcome, though regular follow-up endoscopy should be performed for detecting metachronous early gastric cancer.

Authors+Show Affiliations

Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan. onosho@med.hokudai.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20492338

Citation

Ono, Shouko, et al. "Long-term Treatment of Localized Gastric Marginal Zone B-cell Mucosa Associated Lymphoid Tissue Lymphoma Including Incidence of Metachronous Gastric Cancer." Journal of Gastroenterology and Hepatology, vol. 25, no. 4, 2010, pp. 804-9.
Ono S, Kato M, Takagi K, et al. Long-term treatment of localized gastric marginal zone B-cell mucosa associated lymphoid tissue lymphoma including incidence of metachronous gastric cancer. J Gastroenterol Hepatol. 2010;25(4):804-9.
Ono, S., Kato, M., Takagi, K., Kodaira, J., Kubota, K., Matsuno, Y., Komatsu, Y., & Asaka, M. (2010). Long-term treatment of localized gastric marginal zone B-cell mucosa associated lymphoid tissue lymphoma including incidence of metachronous gastric cancer. Journal of Gastroenterology and Hepatology, 25(4), 804-9. https://doi.org/10.1111/j.1440-1746.2009.06204.x
Ono S, et al. Long-term Treatment of Localized Gastric Marginal Zone B-cell Mucosa Associated Lymphoid Tissue Lymphoma Including Incidence of Metachronous Gastric Cancer. J Gastroenterol Hepatol. 2010;25(4):804-9. PubMed PMID: 20492338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term treatment of localized gastric marginal zone B-cell mucosa associated lymphoid tissue lymphoma including incidence of metachronous gastric cancer. AU - Ono,Shouko, AU - Kato,Mototsugu, AU - Takagi,Kikuko, AU - Kodaira,Junichi, AU - Kubota,Kanako, AU - Matsuno,Yoshihiro, AU - Komatsu,Yoshito, AU - Asaka,Masahiro, PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/8/31/medline SP - 804 EP - 9 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 25 IS - 4 N2 - BACKGROUND AND AIM: According to a few recent reports on the long-term clinical outcome of gastric marginal zone B-cell mucosa associated lymphoid tissue lymphoma (MALT lymphoma); localized gastric MALT lymphoma generally has a favorable prognosis. However, the risk of metachronous gastric cancer has not been evaluated. In this study, we analyzed long-term outcomes of localized gastric MALT lymphoma including the incidence of metachronous gastric cancer. METHODS: Between April 1996 and May 2008, 60 patients (31 men and 29 women; mean age 58.1 years) with localized gastric MALT lymphoma (stage I and II(1) according to Lugano classification) were analyzed retrospectively. RESULTS: Forty-eight patients (82.6%) achieved complete remission by eradication therapy. Radiation therapy was conducted on eight patients as second-line treatment, and all of them achieved remission. The median follow-up period was 76 months (range, 12-157 months). One patient had local relapse after remission for 5 years and three patients developed early gastric cancer without recurrence of lymphoma (5%). All of the three gastric cancers appeared in the same areas where MALT lymphoma had been eradicated. CONCLUSION: Eradication therapy and radiation therapy for localized gastric MALT lymphoma have a favorable long-term outcome, though regular follow-up endoscopy should be performed for detecting metachronous early gastric cancer. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/20492338/Long_term_treatment_of_localized_gastric_marginal_zone_B_cell_mucosa_associated_lymphoid_tissue_lymphoma_including_incidence_of_metachronous_gastric_cancer_ L2 - https://doi.org/10.1111/j.1440-1746.2009.06204.x DB - PRIME DP - Unbound Medicine ER -