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Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications.
Psychiatry Res. 2010 Oct 30; 179(3):291-6.PR

Abstract

New models of interaction between genetic and environmental factors have been proposed to explain the pathogenesis of schizophrenia. The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine regulation and related to negative symptoms, has been previously thought to interact with cannabis use in the modulation of risk of psychosis. The aim of the study was to explore the existence of an interaction between COMT genotype and cannabis use in early stages of psychosis and its effects on the age of onset in a representative group of first-episode psychosis patients. Age of onset, DUP (Duration of Untreated Psychosis) and cannabis use (regular user versus sporadic or non-user) were assessed in 169 Caucasian patients with a first-episode schizophrenia spectrum disorder. COMT polymorphism was typed using PCR of the relevant region followed by digestion with NlaIII and electrophoresis. A multivariate ANCOVA was performed with DUP and age of onset as dependent variables, cannabis and the COMT genotype as fixed factors, and gender as a covariate. The MANCOVA was significant for age of onset and DUP. Cannabis users had a significant earlier age of onset. Age of onset was later in the Met homozygote group (non-significant). The cannabis-COMT interaction showed a significant effect on both DUP and age of onset. Post hoc analyses showed that differences between genotypes were only present in the non-users' group. Based on these results, the use of cannabis could exert a modulator effect on the genotype, suppressing the delay effect for the age of onset in the case of the Met allele patients.

Authors+Show Affiliations

Department of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20493536

Citation

Pelayo-Terán, José María, et al. "Catechol-O-Methyltransferase (COMT) Val158Met Variations and Cannabis Use in First-episode Non-affective Psychosis: Clinical-onset Implications." Psychiatry Research, vol. 179, no. 3, 2010, pp. 291-6.
Pelayo-Terán JM, Pérez-Iglesias R, Mata I, et al. Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications. Psychiatry Res. 2010;179(3):291-6.
Pelayo-Terán, J. M., Pérez-Iglesias, R., Mata, I., Carrasco-Marín, E., Vázquez-Barquero, J. L., & Crespo-Facorro, B. (2010). Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications. Psychiatry Research, 179(3), 291-6. https://doi.org/10.1016/j.psychres.2009.08.022
Pelayo-Terán JM, et al. Catechol-O-Methyltransferase (COMT) Val158Met Variations and Cannabis Use in First-episode Non-affective Psychosis: Clinical-onset Implications. Psychiatry Res. 2010 Oct 30;179(3):291-6. PubMed PMID: 20493536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications. AU - Pelayo-Terán,José María, AU - Pérez-Iglesias,Rocío, AU - Mata,Ignacio, AU - Carrasco-Marín,Eugenio, AU - Vázquez-Barquero,José Luis, AU - Crespo-Facorro,Benedicto, Y1 - 2010/05/21/ PY - 2008/10/15/received PY - 2009/05/13/revised PY - 2009/08/27/accepted PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/12/14/medline SP - 291 EP - 6 JF - Psychiatry research JO - Psychiatry Res VL - 179 IS - 3 N2 - New models of interaction between genetic and environmental factors have been proposed to explain the pathogenesis of schizophrenia. The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine regulation and related to negative symptoms, has been previously thought to interact with cannabis use in the modulation of risk of psychosis. The aim of the study was to explore the existence of an interaction between COMT genotype and cannabis use in early stages of psychosis and its effects on the age of onset in a representative group of first-episode psychosis patients. Age of onset, DUP (Duration of Untreated Psychosis) and cannabis use (regular user versus sporadic or non-user) were assessed in 169 Caucasian patients with a first-episode schizophrenia spectrum disorder. COMT polymorphism was typed using PCR of the relevant region followed by digestion with NlaIII and electrophoresis. A multivariate ANCOVA was performed with DUP and age of onset as dependent variables, cannabis and the COMT genotype as fixed factors, and gender as a covariate. The MANCOVA was significant for age of onset and DUP. Cannabis users had a significant earlier age of onset. Age of onset was later in the Met homozygote group (non-significant). The cannabis-COMT interaction showed a significant effect on both DUP and age of onset. Post hoc analyses showed that differences between genotypes were only present in the non-users' group. Based on these results, the use of cannabis could exert a modulator effect on the genotype, suppressing the delay effect for the age of onset in the case of the Met allele patients. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/20493536/Catechol_O_Methyltransferase__COMT__Val158Met_variations_and_cannabis_use_in_first_episode_non_affective_psychosis:_clinical_onset_implications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-1781(09)00328-X DB - PRIME DP - Unbound Medicine ER -