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Hereditary breast and ovarian cancer (HBOC): clinical features and counseling for BRCA1 and BRCA2, Lynch syndrome, Cowden syndrome, and Li-Fraumeni syndrome.
Obstet Gynecol Clin North Am. 2010 Mar; 37(1):109-33, Table of Contents.OG

Abstract

This article provides an overview of the molecular changes associated with inherited gynecologic malignancies and the incorporation of this information in the counseling of individuals at increased risk for developing malignancies, as well as conventional and emerging approaches to the screening of the general population. Cancer genetic counseling and its role in women's health care is examined. The focus is hereditary breast and ovarian cancer; however, cancer predisposition caused by genes other than BRCA1 and BRCA2 is also considered. The aim is to provide a foundation for counseling based on fundamental knowledge of the genes and their clinical consequences. The reader is then guided through the mechanics of risk assessment for individual patients, concluding with the psychosocial implications of counseling.

Authors+Show Affiliations

Division of Clinical Genetics, Feinberg School of Medicine of Northwestern University, Chicago, IL, USA. lps5@cornell.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20494261

Citation

Shulman, Lee P.. "Hereditary Breast and Ovarian Cancer (HBOC): Clinical Features and Counseling for BRCA1 and BRCA2, Lynch Syndrome, Cowden Syndrome, and Li-Fraumeni Syndrome." Obstetrics and Gynecology Clinics of North America, vol. 37, no. 1, 2010, 109-33, Table of Contents.
Shulman LP. Hereditary breast and ovarian cancer (HBOC): clinical features and counseling for BRCA1 and BRCA2, Lynch syndrome, Cowden syndrome, and Li-Fraumeni syndrome. Obstet Gynecol Clin North Am. 2010;37(1):109-33, Table of Contents.
Shulman, L. P. (2010). Hereditary breast and ovarian cancer (HBOC): clinical features and counseling for BRCA1 and BRCA2, Lynch syndrome, Cowden syndrome, and Li-Fraumeni syndrome. Obstetrics and Gynecology Clinics of North America, 37(1), 109-33, Table of Contents. https://doi.org/10.1016/j.ogc.2010.03.003
Shulman LP. Hereditary Breast and Ovarian Cancer (HBOC): Clinical Features and Counseling for BRCA1 and BRCA2, Lynch Syndrome, Cowden Syndrome, and Li-Fraumeni Syndrome. Obstet Gynecol Clin North Am. 2010;37(1):109-33, Table of Contents. PubMed PMID: 20494261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary breast and ovarian cancer (HBOC): clinical features and counseling for BRCA1 and BRCA2, Lynch syndrome, Cowden syndrome, and Li-Fraumeni syndrome. A1 - Shulman,Lee P, PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/7/1/medline SP - 109-33, Table of Contents JF - Obstetrics and gynecology clinics of North America JO - Obstet Gynecol Clin North Am VL - 37 IS - 1 N2 - This article provides an overview of the molecular changes associated with inherited gynecologic malignancies and the incorporation of this information in the counseling of individuals at increased risk for developing malignancies, as well as conventional and emerging approaches to the screening of the general population. Cancer genetic counseling and its role in women's health care is examined. The focus is hereditary breast and ovarian cancer; however, cancer predisposition caused by genes other than BRCA1 and BRCA2 is also considered. The aim is to provide a foundation for counseling based on fundamental knowledge of the genes and their clinical consequences. The reader is then guided through the mechanics of risk assessment for individual patients, concluding with the psychosocial implications of counseling. SN - 1558-0474 UR - https://www.unboundmedicine.com/medline/citation/20494261/Hereditary_breast_and_ovarian_cancer__HBOC_:_clinical_features_and_counseling_for_BRCA1_and_BRCA2_Lynch_syndrome_Cowden_syndrome_and_Li_Fraumeni_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-8545(10)00025-2 DB - PRIME DP - Unbound Medicine ER -